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Chemosensors
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Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024
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Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 14588

Special Issue Editors

Prof. Dr. Nicole Jaffrezic-Renault

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Guest Editor
Institute of Analytical Sciences, UMR CNRS 5280, Department LSA, 5 Rue de La Doua, 69100 Villeurbanne, France
Interests: biosensors; impedance; immunosensors; conductometric sensors; enzymatic sensors; affinity sensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Camelia Bala

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Director Doctoral School of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania
Interests: sensors and biosensors addressing current emerging problems of clinical; food and environmental importance; bioanalytical chemistry focusing on investigations of basic biochemical mechanisms at bio-interfaces; biomimetic materials and artificial receptors
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Frasconi

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Guest Editor
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy
Interests: supramolecular chemistry; stimuli-responsive materials; biomimetic/sensing materials; chemical sensors; electroanalytical chemistry; biointerfaces; nanobiotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Jose V. Ros-Lis

E-Mail Website
Guest Editor
REDOLí Research Group, Inorganic Chemistry Department, Universitat de València, 46010 Valencia, Spain
Interests: nanomaterial; microwaves; sensors; enzyme inhibition; mesoporous
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue aims to curate a collection of in-depth review papers encompassing comprehensive insights, analysis, and advancements in the field of chemical sensors, biosensors, and related analytical methods and systems. By selectively featuring review and systematic review manuscripts, this series aims to provide a rigorous and consolidated understanding of recent developments, offering valuable insights for researchers and practitioners in this field.

We sincerely welcome you all to contribute comprehensive review articles on a trending topic for peer review and possible publication.

Prof. Dr. Nicole Jaffrezic-Renault
Prof. Dr. Camelia Bala
Dr. Marco Frasconi
Dr. Jose V. Ros-Lis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical devices and sensors
  • biosensors and imaging
  • optical chemical sensors
  • nanosensors
  • analytical method and applications

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (9 papers)

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Review

28 pages, 2338 KiB  
Review
Current and Future Diagnostics for Hepatitis C Virus Infection
by Hussein Zilouchian, Omair Faqah, Md Alamgir Kabir, Dennis Gross, Rachel Pan, Shane Shaifman, Muhammad Awais Younas, Muhammad Abdul Haseeb, Emmanuel Thomas and Waseem Asghar
Chemosensors 2025, 13(2), 31; https://doi.org/10.3390/chemosensors13020031 - 23 Jan 2025
Viewed by 1033
Abstract
Hepatitis C virus (HCV), a member of the Flaviviridae family, is an RNA virus enclosed in an envelope that infects approximately 50 million people worldwide. Despite its significant burden on public health, no vaccine is currently available, and many individuals remain unaware of [...] Read more.
Hepatitis C virus (HCV), a member of the Flaviviridae family, is an RNA virus enclosed in an envelope that infects approximately 50 million people worldwide. Despite its significant burden on public health, no vaccine is currently available, and many individuals remain unaware of their infection due to the often asymptomatic nature of the disease. Early detection of HCV is critical for initiating curative treatments, which can prevent long-term complications such as cirrhosis, liver cancer, and decompensated liver disease. However, conventional diagnostic approaches available, such as enzyme immunoassays (EIAs) and polymerase chain reaction (PCR)-based methods, are often costly, time-intensive, and challenging to be implemented in resource-limited settings. This review provides an overview of HCV disease and the structural components of the virus, illustrating how different diagnostic methods target various parts of the viral structure. It examines current diagnostic tests and assays, highlighting their mechanisms, applications, and limitations, which necessitates the development of improved detection methods. Additionally, the paper explores emerging technologies in HCV detection that could offer affordable, accessible, and easy-to-use diagnostic solutions, particularly for deployment in low-resource and point-of-care settings. These advancements have the potential to contribute significantly to achieving the World Health Organization’s (WHO) target of eliminating HCV as a public threat by 2030. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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35 pages, 4936 KiB  
Review
Multi-Template Molecularly Imprinted Polymeric Electrochemical Biosensors
by Meltem Agar, Maisem Laabei, Hannah S. Leese and Pedro Estrela
Chemosensors 2025, 13(1), 11; https://doi.org/10.3390/chemosensors13010011 - 8 Jan 2025
Viewed by 903
Abstract
Dual- or multi-template molecularly imprinted polymers have been an attractive research field for many years as they allow simultaneous detection of more than one target with high selectivity and sensitivity by creating template-specific recognition sites for multiple targets on the same functional monomer. [...] Read more.
Dual- or multi-template molecularly imprinted polymers have been an attractive research field for many years as they allow simultaneous detection of more than one target with high selectivity and sensitivity by creating template-specific recognition sites for multiple targets on the same functional monomer. Dual/multi-template molecular imprinting techniques have been applied to identify, extract, and detect many targets, from heavy metal ions to viruses, by different methods, such as high-performance liquid chromatography (HPLC), liquid chromatography–mass spectrometry (LC-MS), and piezoelectric, optical, and electrochemical methods. This article focuses on electrochemical sensors based on dual/multi-template molecularly imprinted polymers detecting a wide range of targets by electrochemical methods. Furthermore, this work highlights the use of these sensors for point-of-care applications, their commercialization and their integration with microfluidic systems. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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19 pages, 3172 KiB  
Review
Origami-Inspired Biosensors: Exploring Diverse Applications and Techniques for Shape-Changing Sensor Platforms
by Shikha Patil, Shariq Suleman, Nigar Anzar, Jagriti Narang, Roberto Pilloton, Suna Timur, Emine Guler Celik, Chandra S. Pundir and Sudheesh K. Shukla
Chemosensors 2024, 12(12), 276; https://doi.org/10.3390/chemosensors12120276 - 21 Dec 2024
Viewed by 1057
Abstract
Biosensors are widely used across industries such as healthcare, food safety, and environmental monitoring, offering high stability and sensitivity compared to conventional methods. Recently, origami—the art of folding 2D structures into 3D forms—has emerged as a valuable approach in biosensor development, enabling the [...] Read more.
Biosensors are widely used across industries such as healthcare, food safety, and environmental monitoring, offering high stability and sensitivity compared to conventional methods. Recently, origami—the art of folding 2D structures into 3D forms—has emerged as a valuable approach in biosensor development, enabling the creation of shape-changing devices. These origami-based biosensors are particularly useful in precision medicine, rapid diagnostics, and resource-limited settings, offering affordable, highly precise, and portable solutions with diverse applications. Paper and biological substrates like DNA have been integrated with origami techniques to develop biosensors with enhanced functionality. The incorporation of aptamer origami into both paper and DNA biosensors further increases sensitivity and specificity for target detection. The concept of paper-based origami biosensors originated from using paper as a platform for biological assays, leading to significant advancements in design and functionality. These devices employ folding techniques to create channels and wells for manipulating samples and detecting target molecules through reactions with specific reagents. Similarly, DNA origami, introduced in 2006, has revolutionized biosensors by enabling the creation of precise molecular systems with tunable properties. Paper-based and DNA origami biosensors have immense potential to transform biosensing technologies in healthcare, food safety, and environmental monitoring. This review explores diverse origami-based biosensor techniques and their applications, including the role of aptamer origami in paper and DNA biosensors. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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27 pages, 4617 KiB  
Review
A Review on Analytical Techniques for Quantitative Detection of Biogenic Amines in Aquatic Products
by Zixin Chen, Jing Xie and Jun Mei
Chemosensors 2024, 12(12), 274; https://doi.org/10.3390/chemosensors12120274 - 20 Dec 2024
Viewed by 857
Abstract
Aquatic products contain a large amount of protein, which can promote the production of a variety of biogenic amines through the function of microorganisms. Biogenic amines are a broad category of organic substances that contain nitrogen and have a low molecular weight. The [...] Read more.
Aquatic products contain a large amount of protein, which can promote the production of a variety of biogenic amines through the function of microorganisms. Biogenic amines are a broad category of organic substances that contain nitrogen and have a low molecular weight. The presence of biogenic amines can cause the deterioration and excessive accumulation of aquatic products, which can cause damage to human health. Therefore, it is essential to discover a fast, convenient, and easy to operate method for the determination of biogenic amines in aquatic products. In this paper, the function and research significance of biogenic amines are analyzed from the aspects of their formation, toxicological properties, harm to the human body, and control methods. Several common direct detection techniques and indirect techniques for biogenic amines are briefly introduced especially sensors. This review provides references for efficient detection in the future. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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26 pages, 2108 KiB  
Review
Sustainable Biopolymer-Based Electrochemical Sensors for Trace Heavy Metal Determination in Water: A Comprehensive Review
by Rabiaa Helim, Ali Zazoua and Hafsa Korri-Youssoufi
Chemosensors 2024, 12(12), 267; https://doi.org/10.3390/chemosensors12120267 - 17 Dec 2024
Viewed by 762
Abstract
The growing concern over heavy metal contamination in environmental and industrial settings has intensified the need for sensitive, selective, and cost-effective detection technologies. Electrochemical sensors, due to their high sensitivity, rapid response, and portability, have emerged as promising tools for detecting heavy metals. [...] Read more.
The growing concern over heavy metal contamination in environmental and industrial settings has intensified the need for sensitive, selective, and cost-effective detection technologies. Electrochemical sensors, due to their high sensitivity, rapid response, and portability, have emerged as promising tools for detecting heavy metals. Recent years have seen significant progress in utilizing biopolymer-based materials to enhance the performance of these sensors. Biopolymers, derived from renewable raw materials, have garnered considerable interest in both science and industry. These biopolymer-based composites are increasingly recognized as superior alternatives to conventional non-biodegradable materials because of their ability to degrade through environmental exposure. This review provides a comprehensive overview of recent advancements in biopolymer-based electrochemical sensors for heavy metal detection. It discusses various types of biopolymers and bio-sourced polymers, their extraction methods, and chemical properties. Additionally, it highlights the state of the art in applying biopolymers to electrochemical sensor development for heavy metal detection, synthesizing recent advances and offering insights into design principles, fabrication strategies, and analytical performance. This review underscores the potential of biopolymer-based sensors as cost-effective, eco-friendly, and efficient tools for addressing the pressing issue of heavy metal contamination in water and discusses their advantages and limitations. It also outlines future research directions to further enhance the performance and applicability of these sensors. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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15 pages, 1379 KiB  
Review
Investigating Sepsis-Associated Delirium Through Optical Neuroimaging: A New Frontier in Critical Care Research
by Shixie Jiang, Matthew Gunther, Jose R. Maldonado, Philip A. Efron, Steven T. DeKosky and Huabei Jiang
Chemosensors 2024, 12(12), 264; https://doi.org/10.3390/chemosensors12120264 - 15 Dec 2024
Viewed by 1055
Abstract
Sepsis is a life-threatening syndrome consisting of physiological, pathological, and biochemical abnormalities induced by infection which continues to be a major public health burden. It remains one of the most common reasons for intensive care unit (ICU) admission. Delirium precipitated by sepsis in [...] Read more.
Sepsis is a life-threatening syndrome consisting of physiological, pathological, and biochemical abnormalities induced by infection which continues to be a major public health burden. It remains one of the most common reasons for intensive care unit (ICU) admission. Delirium precipitated by sepsis in the intensive care setting is one of its most common neuropsychiatric complications that leads to prolonged hospitalization, increased mortality, and an increased risk of incident dementia. Understanding the pathophysiology and neurobiological mechanisms of sepsis-associated delirium is difficult; neuroimaging biomarkers are lacking due to difficulties with imaging critically ill patients. Optical imaging techniques, including near-infrared spectroscopy and diffuse optical tomography are potentially promising approaches for investigating this pathophysiology due to their portability and high spatiotemporal resolution. In this review, we examine the emergence of optical neuroimaging techniques for the study of sepsis-associated delirium in the ICU and how they can further advance our knowledge and lead to the development of improved preventative, predictive, and therapeutic strategies. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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45 pages, 9504 KiB  
Review
Nanomaterial-Based Electrochemical Sensors for the Detection of Pharmaceutical Drugs
by Shweta J. Malode, Mohammed Ali Alshehri and Nagaraj P. Shetti
Chemosensors 2024, 12(11), 234; https://doi.org/10.3390/chemosensors12110234 - 11 Nov 2024
Viewed by 2386
Abstract
The rapidly increasing human population has led to new biological and environmental challenges. These challenges, in turn, have contributed to the rapid growth of the pharmaceutical sector. Quality control in pharmaceutical manufacturing and drug delivery necessitates portable, sensitive, precise, and cost-effective devices to [...] Read more.
The rapidly increasing human population has led to new biological and environmental challenges. These challenges, in turn, have contributed to the rapid growth of the pharmaceutical sector. Quality control in pharmaceutical manufacturing and drug delivery necessitates portable, sensitive, precise, and cost-effective devices to monitor patient dosing and assess pharmaceutical hazards. This study highlights the attributes and applications of the current nanomaterial-based sensors for drug detection, emphasizing the potential of these devices to advance the detection of bioactive molecules, thereby promoting human health and environmental protection on a large scale. Electrochemical sensors, in particular, have become invaluable in bioimaging, electrochemical analysis, and drug delivery due to their high specificity, selectivity, and stability across cycles. This review focuses on recent advancements in electrochemical devices for healthcare applications, detailing their production, analytical performance, and clinical uses. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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Graphical abstract

24 pages, 5048 KiB  
Review
Humidity Sensing Using Polymers: A Critical Review of Current Technologies and Emerging Trends
by Jintian Qian, Ruiqin Tan, Mingxia Feng, Wenfeng Shen, Dawu Lv and Weijie Song
Chemosensors 2024, 12(11), 230; https://doi.org/10.3390/chemosensors12110230 - 2 Nov 2024
Cited by 1 | Viewed by 3747
Abstract
In the post-pandemic era, human demand for a healthy lifestyle and a smart society has surged, leading to vibrant growth in the field of flexible electronic sensor technology for health monitoring. Flexible polymer humidity sensors are not only capable of the real-time monitoring [...] Read more.
In the post-pandemic era, human demand for a healthy lifestyle and a smart society has surged, leading to vibrant growth in the field of flexible electronic sensor technology for health monitoring. Flexible polymer humidity sensors are not only capable of the real-time monitoring of human respiration and skin moisture information but also serve as a non-contact human–machine interaction method. In addition, the development of moist-electric generation technology is expected to break free from the traditional reliance of flexible electronic devices on power equipment, which is of significant importance for the miniaturization, reliability, and environmentally friendly development of flexible devices. Currently, flexible polymer humidity sensors are playing a significant role in the field of wearable electronic devices and thus have attracted considerable attention. This review begins by introducing the structural types and working principles of various humidity sensors, including the types of capacitive, impedance/resistive, frequency-based, fiber optic, and voltage-based sensors. It mainly focuses on the latest research advancements in flexible polymer humidity sensors, particularly in the modification of humidity-sensitive materials, sensor fabrication, and hygrosensitivity mechanisms. Studies on material composites including different types of polymers, polymers combined with porous nanostructured materials, polymers combined with metal oxides, and two-dimensional materials are reviewed, along with a comparative summary of the fabrication and performance mechanisms of related devices. This paper concludes with a discussion on the current challenges and opportunities faced by flexible polymer humidity sensors, providing new research perspectives for their future development. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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32 pages, 3921 KiB  
Review
Biosensors for Food Mycotoxin Determination: A Comparative and Critical Review
by Aurelia Magdalena Pisoschi, Florin Iordache, Loredana Stanca, Elena Mitranescu, Liliana Bader Stoica, Ovidiu Ionut Geicu, Liviu Bilteanu and Andreea Iren Serban
Chemosensors 2024, 12(6), 92; https://doi.org/10.3390/chemosensors12060092 - 30 May 2024
Cited by 2 | Viewed by 1778
Abstract
The need for performant analytical methodologies to assess mycotoxins is vital, given the negative health impact of these compounds. Biosensors are analytical devices that consist of a biological element for recognizing the analyte and a transducer, which translates the biorecognition event into a [...] Read more.
The need for performant analytical methodologies to assess mycotoxins is vital, given the negative health impact of these compounds. Biosensors are analytical devices that consist of a biological element for recognizing the analyte and a transducer, which translates the biorecognition event into a signal proportional to the analyte concentration. The biorecognition elements can be enzymes, antibodies, or DNA fragments. The modalities of detection can be optical, electrochemical, thermal, or mass-sensitive. These analytical tools represent viable alternatives to laborious, expensive traditional methods and are characterized by specificity given by the biorecognition element, sensitivity, fast response, portability, multi-modal detection, and the possibility of in situ application. The present paper focuses on a comprehensive view, enriched with a critical, comparative perspective on mycotoxin assay using biosensors. The use of different biorecognition elements and detection modes are discussed comparatively. Nanomaterials with optical and electrochemical features can be exploited in association with a variety of biorecognition elements. Analytical parameters are reviewed along with a broad range of applications. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2024)
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