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Recent Advances in Ovarian Stem Cells

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 3370

Special Issue Editor


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Guest Editor
Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, Seoul 03080, Korea
Interests: stem cell biology; stem cell therapy; reproductive biology; reproductive engineering
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Special Issue Information

Dear Colleagues,

In recent years, new therapeutic approaches are in high demand due to the increases in clinical symptoms which could be solved by a new source of female germ cells. The question of de novo synthesis of oocytes and the ability of pluripotent stem cells to differentiate into germ cells triggers the concept of “ovarian stem cells”.

The goal of this Special Issue is the communication of stem cell technology and concept of ovarian stem cells to new scientific disciplines regarding female germ cell generation.

The Special Issue includes various approaches to isolation and culture of female germ cells, stem cell differentiation into gametes, biomaterials for generation of female germ cells and tissue engineering for the generation of germ cells, in vivo models and therapeutic approach using stem cell-derived germ cells.

Original articles and reviews will be welcome for submission, and the fast peer-review process will enhance the impact of submitted articles.

Dr. Yoon Young Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • ovarian stem cells
  • female germ cell
  • stem cell differentiation
  • oocytes
  • stem cell therapy
  • reproductive biology
  • reproductive engineering

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Published Papers (1 paper)

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Review

12 pages, 1646 KiB  
Review
Ovarian Stem Cells (OSCs) from the Cryopreserved Ovarian Cortex: A Potential for Neo-Oogenesis in Women with Cancer-Treatment Related Infertility: A Case Report and a Review of Literature
by Erica Silvestris, Carla Minoia, Attilio Guarini, Giuseppina Opinto, Antonio Negri, Miriam Dellino, Raffaele Tinelli, Gennaro Cormio, Angelo Virgilio Paradiso and Giuseppe De Palma
Curr. Issues Mol. Biol. 2022, 44(5), 2309-2320; https://doi.org/10.3390/cimb44050157 - 19 May 2022
Cited by 5 | Viewed by 3030
Abstract
Cancer treatment related infertility (CTRI) affects more than one third of young women undergoing anti-cancer protocols, inducing a premature exhaustion of the ovarian reserve. In addition to ovarian suppression by GnRHa, oocyte and cortex cryopreservation has gained interest in patients with estrogen-sensitive tumors [...] Read more.
Cancer treatment related infertility (CTRI) affects more than one third of young women undergoing anti-cancer protocols, inducing a premature exhaustion of the ovarian reserve. In addition to ovarian suppression by GnRHa, oocyte and cortex cryopreservation has gained interest in patients with estrogen-sensitive tumors for whom the hormonal burst to prompt the multiple follicular growth could provide a further pro-life tumor pulsing. On the other hand, cortex reimplantation implies a few drawbacks due to the unknown consistency of the follicles to be reimplanted or the risk of reintroducing malignant cells. The capability of ovarian stem cells (OCSs) from fresh ovarian cortex fragments to differentiate in vitro to mature oocytes provides a tool to overcome these drawbacks. In fact, since ovarian cortex sampling and cryopreservation is practicable before gonadotoxic treatments, the recruitment of OSCs from defrosted fragments could provide a novel opportunity to verify their suitability to be expanded in vitro as oocyte like cells (OLCs). Here, we describe in very preliminary experiments the consistency of an OSC population from a single cryopreserved ovarian cortex after thawing as well as both their viability and their suitability to be further explored in their property to differentiate in OLCs, thus reinforcing interest in stemness studies in the treatment of female CTRI. Full article
(This article belongs to the Special Issue Recent Advances in Ovarian Stem Cells)
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