Advanced Delivery Systems for Dermatologic and Dermocosmetics Products

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 18788

Special Issue Editors


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Guest Editor
Department of Biotechnology, Health Sciences Institute, Federal University of Bahia (UFBA), Salvador 40110-902, BA, Brazil
Interests: colloids; lyotropic liquid crystals; nanoparticulate systems; skin inflammation; drug delivery systems
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Special Issue Information

Dear Colleagues,

The objective of developing delivery systems for skin is to enhance the effectiveness and efficiency of delivering active ingredients to specific target areas of the skin; this includes creating innovative delivery methods that optimize the absorption and penetration of dermatologic and dermocosmetic products, resulting in improved treatment outcomes and benefits. By developing advanced delivery systems, including nanomaterials and biomaterials, researchers and developers aim to overcome the limitations of conventional delivery methods, such as topical creams, gels and lotions, by increasing the bioavailability, penetration and sustained release of active ingredients; this may involve creating products with easy application methods, such as sprays, patches, and microneedles, that ensure accurate and consistent dosage administration. Moreover, these delivery systems strive to improve the sensory experience by minimizing potential side effects or skin irritations associated with certain active ingredients; this allows for better targeting of skin conditions, such as acne, eczema, hyperpigmentation, and ageing signs, as well as sun protection, moisturizer, skin-lightening products, and personal care products.

Dr. Bruno Fonseca-Santos
Dr. Marlus Chorilli
Guest Editors

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Keywords

  • dermatology
  • photoaging
  • nanoparticles
  • penetration enhancers
  • skin penetration assessment
  • non-invasive efficacy methods
  • alternative methods for toxicity
  • sunscreens
  • vitamins
  • acne

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Published Papers (6 papers)

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Research

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17 pages, 5873 KiB  
Article
Development of Transethosomes Loaded with Fruit Extract from Carissa carandas L. as a Brightening and Anti-Aging Cosmeceutical Ingredient
by Sitthiphong Soradech, Worawan Tiatragoon, Phongsapak Phanphothong, Kanyarat Ouamkan, Pattarawadee Kengkwasingh, Supatjaree Ruengsomwong, Somkamol Intawong and Thanchanok Muangman
Cosmetics 2024, 11(6), 199; https://doi.org/10.3390/cosmetics11060199 - 21 Nov 2024
Viewed by 254
Abstract
The ethanolic extract of Carissa carandas L. (ECE) inhibited the enzyme tyrosinase, enhanced the proliferation of normal human dermal fibroblast cells, and increased the formation of collagen type I, indicating possible anti-aging and whitening effects. However, the stratum corneum acts as a rate-limiting [...] Read more.
The ethanolic extract of Carissa carandas L. (ECE) inhibited the enzyme tyrosinase, enhanced the proliferation of normal human dermal fibroblast cells, and increased the formation of collagen type I, indicating possible anti-aging and whitening effects. However, the stratum corneum acts as a rate-limiting stage in the absorption of herbal extracts through the skin, resulting in limited absorption of ECE via the skin, which affects the efficacy of ECE. The purpose of this study was to develop ECE encapsulated in transethosomes for improved skin penetration as a novel brightening and anti-aging cosmeceutical ingredient. Transethosomes were successfully developed using the sonication technique, with a suitable formulation including 1.00% (w/w) phosphatidylcholine, 0.10% (w/w) polysorbate 80 and 28.55% (v/v) ethanol. The physicochemical properties, encapsulation efficacy, in vitro skin permeation and toxicity of ECE-loaded transethosomes were also investigated. The result showed that the percentages of encapsulation of ECE loaded in transethosomes increased slightly with higher concentrations of the ECE. When compared to the liquid extract, the ECE loaded in transethosomes significantly increased (p < 0.05) skin penetration. Furthermore, ECE loaded with transethosomes showed low cytotoxicity in normal human dermal fibroblast cells and caused no skin irritation when evaluated on reconstructed human epidermal skin. Given these abilities, it is evident that transethosomes containing ECE are highly effective anti-aging and skin-whitening agents, making them a promising new cosmeceutical ingredient. Full article
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11 pages, 7113 KiB  
Article
A Split-Face Comparison of Novel Microneedle Patch versus Botulinum Toxin-A and Microneedle Patch for Improvement in Undereye Skin Texture
by Polen Te, Jitlada Meephansan, Punyaphat Sirithanabadeekul, Purit Pureesrisak, Kittipong Tantisantisom, Sattra Thongma, Yossawat Rayanasukha, Punyanuch Adulyaritthikul and Paisan Khanchaitit
Cosmetics 2024, 11(3), 100; https://doi.org/10.3390/cosmetics11030100 - 17 Jun 2024
Viewed by 1717
Abstract
(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye [...] Read more.
(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye skin texture and wrinkles against patch cosmesis with diluted botulinum toxin-A. (2) Methods: A total of 23 Thai females volunteered for this prospective clinical trial. Each participant was treated according to a split-face design, with the application of diluted botulinum toxin-A through MNP technology to the right undereye and a normal saline MNP application to the left undereye. Test areas were recorded at baseline and 2, 4, 8, 12, and 16 weeks after the initial treatment. (3) Results: Botulinum toxin-A was successfully delivered to the skin by MNP technology. After the initial treatment, these novel transdermal drug delivery patches significantly improved infraorbital hollowness at week 8 and wrinkles at week 16. In addition, the skin surface was markedly enhanced, with no adverse effects observed during the trial. (4) Conclusions: Novel MNPs are an effective and safe technology for use in the management of undereye skin aging. Combination treatment with botulinum toxin-A-impregnated devices gave a higher patient satisfaction than MNPs alone. Full article
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16 pages, 2621 KiB  
Article
Nanoemulsions Containing Passiflora quadrangularis L. Fruit Extracts for Cosmetic Application and Skin Efficacy Study
by Nareekan Yanasan, Worrapon Wangkananon, Surapol Natakankitkul and Kanokwan Kiattisin
Cosmetics 2024, 11(2), 57; https://doi.org/10.3390/cosmetics11020057 - 4 Apr 2024
Cited by 2 | Viewed by 2518
Abstract
This study aimed to determine the anti-collagenase, anti-elastase, and anti-hyaluronidase activities of Passiflora quadrangularis fruit extracts (epicarp, mesocarp, endocarp, and seed), develop stable nanoemulsions, and evaluate the efficacy of the nanoemulsions containing extracts in human volunteers. The results indicated that the epicarp and [...] Read more.
This study aimed to determine the anti-collagenase, anti-elastase, and anti-hyaluronidase activities of Passiflora quadrangularis fruit extracts (epicarp, mesocarp, endocarp, and seed), develop stable nanoemulsions, and evaluate the efficacy of the nanoemulsions containing extracts in human volunteers. The results indicated that the epicarp and seed extracts exhibited collagenase, elastase, and hyaluronidase inhibition effects. Gallic acid was identified in the extracts, with the highest concentration found in the endocarp extract (1449.35 mg gallic acid/g extract) followed by the seed extract (839.63 mg gallic acid/g extract). The endocarp and seed extracts demonstrated good stability at different temperatures. Consequently, these extracts were selected for incorporation into nanoemulsions due to their high yield, excellent anti-tyrosinase and anti-aging activity, and good stability, making them suitable for cosmetic products. The nanoemulsions were prepared using the ultrasonication method, resulting in a particle size of 133.1 ± 0.8 nm, a polydispersity index of 0.33 ± 0.03, and a zeta potential of −61.8 ± 0.6 mV, indicating good stability. The nano-serum containing extracts was non-irritating and safe for the skin. Skin evaluation among human volunteers after 60 days of application revealed improvements in skin hydration and reduction in wrinkles. In conclusion, nanoemulsions containing P. quadrangularis fruit extracts have the potential to be effective cosmetic products. Full article
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23 pages, 11892 KiB  
Article
Nanoemulsions Containing Mucuna pruriens (L.) DC. Seed Extract for Cosmetic Applications
by Suwaporn Chookiat, Tinnakorn Theansungnoen, Kanokwan Kiattisin and Aekkhaluck Intharuksa
Cosmetics 2024, 11(1), 29; https://doi.org/10.3390/cosmetics11010029 - 12 Feb 2024
Cited by 2 | Viewed by 3480
Abstract
Mucuna pruriens is a medicinal plant whose seeds have various types of pharmacological activities and are used in many traditional medicines. The aim of this study was to evaluate the phytochemicals as well as the anti-aging, antioxidant, and moisturizing properties of seed extracts [...] Read more.
Mucuna pruriens is a medicinal plant whose seeds have various types of pharmacological activities and are used in many traditional medicines. The aim of this study was to evaluate the phytochemicals as well as the anti-aging, antioxidant, and moisturizing properties of seed extracts of M. pruriens var. pruriens and M. pruriens var. utilis. In addition, the best extract was selected for the development of nanoemulsions. M. pruriens var. utilis had the highest total phenolic and total flavonoid contents. It had good antioxidant activity (the IC50 of DPPH was 4.87 µg/mL, the FRAP value was 1.63 mg of FeSO4/mg of extract, and the percentage of lipid peroxidation was 80.19%) and anti-aging activity (the percentages of inhibition of hyaluronidase, collagenase, and elastase were 26.41%, 51.16%, and 22.78%, respectively). The occlusive factor was 46.12 ± 1.72. Therefore, M. pruriens var. utilis seed extract was selected for the preparation of nanoemulsions. The results showed that the size, PDI, and zeta potential of nanoemulsions containing M. pruriens var. utilis seed extract at day 30 did not significantly differ from those at day 0. In addition, the %EE was 63.46%. A study of skin permeation showed that the retention in the membrane after six hours of skin permeation study was 44.19%. Therefore, nanoemulsions containing M. pruriens var. utilis seed extract have good potential for further use in cosmetic applications. Full article
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Review

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29 pages, 1076 KiB  
Review
High-Tech Sustainable Beauty: Exploring Nanotechnology for the Development of Cosmetics Using Plant and Animal By-Products
by Gabriela Braga Barros Nhani, Leonardo Delello Di Filippo, Geanne Aparecida de Paula, Vitoria Ribeiro Mantovanelli, Patricia Pereira da Fonseca, Felipe Mota Tashiro, Diana Coêlho Monteiro, Bruno Fonseca-Santos, Jonatas L. Duarte and Marlus Chorilli
Cosmetics 2024, 11(4), 112; https://doi.org/10.3390/cosmetics11040112 - 6 Jul 2024
Cited by 1 | Viewed by 2761
Abstract
In a world increasingly focused on eco-conscious living, the cosmetic industry is actively adopting nanotechnology to transform plant and animal by-products into high-value beauty products. This comprehensive review explores the innovative and sustainable approaches for extracting and utilizing bioactive compounds from these by-products. [...] Read more.
In a world increasingly focused on eco-conscious living, the cosmetic industry is actively adopting nanotechnology to transform plant and animal by-products into high-value beauty products. This comprehensive review explores the innovative and sustainable approaches for extracting and utilizing bioactive compounds from these by-products. The application of nanocarrier systems is highlighted for their role in enhancing the delivery efficacy and safety of these ingredients in skincare and beauty products. Consumer demand and environmental concerns drive the shift towards natural and sustainable cosmetic products. Traditional cosmetic production often involves significant ecological impacts, prompting the industry to seek greener alternatives. This review addresses the critical need for sustainable beauty solutions that align with global sustainability goals, particularly those outlined in the 2030 Agenda for Sustainable Development. The review provides valuable insights into current trends and future directions in sustainable cosmetics by focusing on nanotechnology and by-products. The review uniquely integrates nanotechnology with sustainability practices in the cosmetic industry. It details the benefits of using nanocarriers to improve the stability, bioavailability, and efficacy of bioactive compounds derived from natural waste. This intersection of high-tech methodologies and sustainability offers a novel perspective on cosmetic innovation. Future research should focus on overcoming the technical, regulatory, and economic challenges of scaling up nanotechnology applications. Investigations should include the development of transparent supply chains, standardization methods for characterizing nanoparticles, and comprehensive lifecycle assessments to ensure environmental safety. Additionally, fostering collaboration between scientific research, industry practices, and consumer education is vital for advancing sustainable practices. This review contributes to the broader discourse on sustainable beauty by presenting a clear pathway for integrating these innovative approaches. It ensures that future cosmetic products meet consumer expectations for efficacy and safety and promote environmental stewardship and a circular economy, ultimately benefiting both the skin and the planet. Full article
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21 pages, 403 KiB  
Review
Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids
by Inês Ferreira, Carla M. Lopes and Maria Helena Amaral
Cosmetics 2024, 11(1), 22; https://doi.org/10.3390/cosmetics11010022 - 6 Feb 2024
Cited by 4 | Viewed by 7090
Abstract
Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions of people around the world. The multifactorial nature of this disorder requires innovative and effective treatment strategies. Over time, there has been a growing interest regarding the use [...] Read more.
Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions of people around the world. The multifactorial nature of this disorder requires innovative and effective treatment strategies. Over time, there has been a growing interest regarding the use of natural topical therapies, with cannabinoids emerging as a promising group of compounds for investigation. In the context of acne treatment, cannabinoids are of particular interest due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, and antimicrobial activities. Among these bioactive compounds, cannabidiol stands out as a notable derivative, exhibiting a promising spectrum of therapeutic actions. Pre-clinical and clinical studies have proven its ability to modulate sebum production, reduce inflammation, and inhibit bacterial proliferation—all of which are critical components in the pathogenesis of this dermatosis. This review provides a comprehensive overview of cannabinoids’ potential as a novel and holistic approach to acne vulgaris treatment and summarizes recent developments in this area. Full article
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