Deep Learning Techniques for Medical Image Analysis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Machine Learning and Artificial Intelligence in Diagnostics".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 5984

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: biomedical ultrasonics; quantitative ultrasound for biological tissue characterization; ultrasound wave propagation in biological tissues; medical signal/image processing; artificial intelligence in medicine
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Special Issue Information

Dear Colleagues,

In recent years, deep learning techniques have been widely used in medical image analysis. These techniques employ deep neural networks to automatically extract multi-level, multi-scale, abundant information (features) from image data, which is hard for conventional machine learning techniques which use hand-crafted feature parameters, including supervised learning (with task-driven models), unsupervised or generative learning (with data-driven models), semi-supervised learning (with hybrid task-driven and data-driven models), reinforcement learning (with environment-driven models), and physics-informed learning (hybrid task-driven and physics-driven models). The analyzed imaging modalities can include structural imaging such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound imaging, and ultrasound computed tomography, as well as functional imaging such as functional MRI, positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional ultrasound imaging, whether two-dimensional, three-dimensional, or even four-dimensional (three-dimensional plus temporal). The vast applications of deep learning techniques in medical image analysis cover lesion detection and segmentation, disease diagnosis, treatment monitoring, efficacy evaluation, prognostic prediction, and even biomechanical analysis. In addition to medical image post-processing, deep learning techniques can also be applied to the front-end (e.g., image reconstruction) to enhance the quality of medical imaging.

Given the high level of research interest and clinical application prospects, deep learning techniques have continued to develop, especially in the field of medical image analysis. This Special Issue aims to report on state-of-the-art deep learning techniques applied to medical image analysis. Contributions related to deep learning techniques in medical image analysis are welcome.

Dr. Zhuhuang Zhou
Guest Editor

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Keywords

  • deep learning
  • supervised learning
  • unsupervised learning
  • semi-supervised learning
  • self-supervised learning
  • generative learning
  • deep neural networks
  • convolutional neural networks
  • physics-informed neural networks
  • X-ray imaging
  • computed tomography (CT)
  • magnetic resonance imaging (MRI)
  • ultrasound imaging
  • ultrasound computed tomography
  • functional MRI
  • positron emission tomography (PET)
  • single-photon emission computed tomography (SPECT)
  • functional ultrasound imaging
  • image reconstruction

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Published Papers (5 papers)

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Research

12 pages, 5034 KiB  
Article
YOLOv8-Based System for Nail Capillary Detection on a Single-Board Computer
by Seda Arslan Tuncer, Muhammed Yildirim, Taner Tuncer and Mehmet Kamil Mülayim
Diagnostics 2024, 14(17), 1843; https://doi.org/10.3390/diagnostics14171843 - 23 Aug 2024
Viewed by 673
Abstract
Nail capillaroscopic examination is an inexpensive and easily applicable method to identify capillary morphological changes in patients with conditions such as systemic sclerosis and Raynaud’s. The detection of changes in capillaries makes an important contribution to diagnosing these diseases. Capillary morphology is important [...] Read more.
Nail capillaroscopic examination is an inexpensive and easily applicable method to identify capillary morphological changes in patients with conditions such as systemic sclerosis and Raynaud’s. The detection of changes in capillaries makes an important contribution to diagnosing these diseases. Capillary morphology is important in the symptoms of these diseases, and capillary diameter, visibility, distribution, length, microbleeds, blood flow, and density are important indicators in capillaroscopic evaluation. Manual examination to determine these parameters is subjective, causes inconsistent results, and is labor-intensive and time-consuming. To overcome these problems, a YOLOv8s-based system was proposed in this paper to detect the number, thickness, and density of capillaries in the nail bed. The system’s components include database systems that store the analysis results, artificial intelligence-based software that runs on the SBC (Single-Board Computer), and recorded microscope images. mAP and F1_score parameters were used to evaluate the system’s performance, and values of 0.882 and 0.83 were obtained. The proposed system is promising in improving the diagnosis process of diseases such as systemic sclerosis and Raynaud’s by providing objective measurements and the early diagnosis and monitoring of diseases. Full article
(This article belongs to the Special Issue Deep Learning Techniques for Medical Image Analysis)
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15 pages, 6316 KiB  
Article
Deep Learning Based Automatic Left Ventricle Segmentation from the Transgastric Short-Axis View on Transesophageal Echocardiography: A Feasibility Study
by Yuan Tian, Wenting Qin, Zihang Zhao, Chunrong Wang, Yajie Tian, Yuelun Zhang, Kai He, Yuguan Zhang, Le Shen, Zhuhuang Zhou and Chunhua Yu
Diagnostics 2024, 14(15), 1655; https://doi.org/10.3390/diagnostics14151655 - 31 Jul 2024
Viewed by 759
Abstract
Segmenting the left ventricle from the transgastric short-axis views (TSVs) on transesophageal echocardiography (TEE) is the cornerstone for cardiovascular assessment during perioperative management. Even for seasoned professionals, the procedure remains time-consuming and experience-dependent. The current study aims to evaluate the feasibility of deep [...] Read more.
Segmenting the left ventricle from the transgastric short-axis views (TSVs) on transesophageal echocardiography (TEE) is the cornerstone for cardiovascular assessment during perioperative management. Even for seasoned professionals, the procedure remains time-consuming and experience-dependent. The current study aims to evaluate the feasibility of deep learning for automatic segmentation by assessing the validity of different U-Net algorithms. A large dataset containing 1388 TSV acquisitions was retrospectively collected from 451 patients (32% women, average age 53.42 years) who underwent perioperative TEE between July 2015 and October 2023. With image preprocessing and data augmentation, 3336 images were included in the training set, 138 images in the validation set, and 138 images in the test set. Four deep neural networks (U-Net, Attention U-Net, UNet++, and UNeXt) were employed for left ventricle segmentation and compared in terms of the Jaccard similarity coefficient (JSC) and Dice similarity coefficient (DSC) on the test set, as well as the number of network parameters, training time, and inference time. The Attention U-Net and U-Net++ models performed better in terms of JSC (the highest average JSC: 86.02%) and DSC (the highest average DSC: 92.00%), the UNeXt model had the smallest network parameters (1.47 million), and the U-Net model had the least training time (6428.65 s) and inference time for a single image (101.75 ms). The Attention U-Net model outperformed the other three models in challenging cases, including the impaired boundary of left ventricle and the artifact of the papillary muscle. This pioneering exploration demonstrated the feasibility of deep learning for the segmentation of the left ventricle from TSV on TEE, which will facilitate an accelerated and objective alternative of cardiovascular assessment for perioperative management. Full article
(This article belongs to the Special Issue Deep Learning Techniques for Medical Image Analysis)
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22 pages, 5659 KiB  
Article
Exploring the Impact of Noise and Image Quality on Deep Learning Performance in DXA Images
by Dildar Hussain and Yeong Hyeon Gu
Diagnostics 2024, 14(13), 1328; https://doi.org/10.3390/diagnostics14131328 - 22 Jun 2024
Viewed by 1545
Abstract
Background and Objective: Segmentation of the femur in Dual-Energy X-ray (DXA) images poses challenges due to reduced contrast, noise, bone shape variations, and inconsistent X-ray beam penetration. In this study, we investigate the relationship between noise and certain deep learning (DL) techniques for [...] Read more.
Background and Objective: Segmentation of the femur in Dual-Energy X-ray (DXA) images poses challenges due to reduced contrast, noise, bone shape variations, and inconsistent X-ray beam penetration. In this study, we investigate the relationship between noise and certain deep learning (DL) techniques for semantic segmentation of the femur to enhance segmentation and bone mineral density (BMD) accuracy by incorporating noise reduction methods into DL models. Methods: Convolutional neural network (CNN)-based models were employed to segment femurs in DXA images and evaluate the effects of noise reduction filters on segmentation accuracy and their effect on BMD calculation. Various noise reduction techniques were integrated into DL-based models to enhance image quality before training. We assessed the performance of the fully convolutional neural network (FCNN) in comparison to noise reduction algorithms and manual segmentation methods. Results: Our study demonstrated that the FCNN outperformed noise reduction algorithms in enhancing segmentation accuracy and enabling precise calculation of BMD. The FCNN-based segmentation approach achieved a segmentation accuracy of 98.84% and a correlation coefficient of 0.9928 for BMD measurements, indicating its effectiveness in the clinical diagnosis of osteoporosis. Conclusions: In conclusion, integrating noise reduction techniques into DL-based models significantly improves femur segmentation accuracy in DXA images. The FCNN model, in particular, shows promising results in enhancing BMD calculation and clinical diagnosis of osteoporosis. These findings highlight the potential of DL techniques in addressing segmentation challenges and improving diagnostic accuracy in medical imaging. Full article
(This article belongs to the Special Issue Deep Learning Techniques for Medical Image Analysis)
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14 pages, 3521 KiB  
Article
Performance Comparison of Convolutional Neural Network-Based Hearing Loss Classification Model Using Auditory Brainstem Response Data
by Jun Ma, Seong Jun Choi, Sungyeup Kim and Min Hong
Diagnostics 2024, 14(12), 1232; https://doi.org/10.3390/diagnostics14121232 - 12 Jun 2024
Viewed by 873
Abstract
This study evaluates the efficacy of several Convolutional Neural Network (CNN) models for the classification of hearing loss in patients using preprocessed auditory brainstem response (ABR) image data. Specifically, we employed six CNN architectures—VGG16, VGG19, DenseNet121, DenseNet-201, AlexNet, and InceptionV3—to differentiate between patients [...] Read more.
This study evaluates the efficacy of several Convolutional Neural Network (CNN) models for the classification of hearing loss in patients using preprocessed auditory brainstem response (ABR) image data. Specifically, we employed six CNN architectures—VGG16, VGG19, DenseNet121, DenseNet-201, AlexNet, and InceptionV3—to differentiate between patients with hearing loss and those with normal hearing. A dataset comprising 7990 preprocessed ABR images was utilized to assess the performance and accuracy of these models. Each model was systematically tested to determine its capability to accurately classify hearing loss. A comparative analysis of the models focused on metrics of accuracy and computational efficiency. The results indicated that the AlexNet model exhibited superior performance, achieving an accuracy of 95.93%. The findings from this research suggest that deep learning models, particularly AlexNet in this instance, hold significant potential for automating the diagnosis of hearing loss using ABR graph data. Future work will aim to refine these models to enhance their diagnostic accuracy and efficiency, fostering their practical application in clinical settings. Full article
(This article belongs to the Special Issue Deep Learning Techniques for Medical Image Analysis)
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12 pages, 3205 KiB  
Article
Deep Learning Detection and Segmentation of Facet Joints in Ultrasound Images Based on Convolutional Neural Networks and Enhanced Data Annotation
by Lingeer Wu, Di Xia, Jin Wang, Si Chen, Xulei Cui, Le Shen and Yuguang Huang
Diagnostics 2024, 14(7), 755; https://doi.org/10.3390/diagnostics14070755 - 2 Apr 2024
Viewed by 1197
Abstract
The facet joint injection is the most common procedure used to release lower back pain. In this paper, we proposed a deep learning method for detecting and segmenting facet joints in ultrasound images based on convolutional neural networks (CNNs) and enhanced data annotation. [...] Read more.
The facet joint injection is the most common procedure used to release lower back pain. In this paper, we proposed a deep learning method for detecting and segmenting facet joints in ultrasound images based on convolutional neural networks (CNNs) and enhanced data annotation. In the enhanced data annotation, a facet joint was considered as the first target and the ventral complex as the second target to improve the capability of CNNs in recognizing the facet joint. A total of 300 cases of patients undergoing pain treatment were included. The ultrasound images were captured and labeled by two professional anesthesiologists, and then augmented to train a deep learning model based on the Mask Region-based CNN (Mask R-CNN). The performance of the deep learning model was evaluated using the average precision (AP) on the testing sets. The data augmentation and data annotation methods were found to improve the AP. The AP50 for facet joint detection and segmentation was 90.4% and 85.0%, respectively, demonstrating the satisfying performance of the deep learning model. We presented a deep learning method for facet joint detection and segmentation in ultrasound images based on enhanced data annotation and the Mask R-CNN. The feasibility and potential of deep learning techniques in facet joint ultrasound image analysis have been demonstrated. Full article
(This article belongs to the Special Issue Deep Learning Techniques for Medical Image Analysis)
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