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Novel Molecular Research in Skin Inflammation
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Novel Molecular Research in Skin Inflammation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 16997

Special Issue Editors

Dr. Anna Campanati

E-Mail Website
Guest Editor
Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, 60121 Ancona, Italy
Interests: immune-mediated skin diseases; psoriasis; suppurative hidradenitis; chronic urticaria; atopic dermatitis; adnexal diseases; auto-inflammatory dermatoses; acne; contact dermatitis; scleroderma
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuela Emanuela Martina

E-Mail Website
Guest Editor
Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, 60121 Ancona, Italy
Interests: immune-mediated skin diseases; psoriasis; suppurative hidradenitis; chronic urticaria; atopic dermatitis; adnexal diseases; auto-inflammatory dermatoses; acne; contact dermatitis; scleroderma
Dr. Giulia Radi

E-Mail Website
Guest Editor
Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, 60121 Ancona, Italy
Interests: immune-mediated skin diseases; psoriasis; suppurative hidradenitis; chronic urticaria; atopic dermatitis; adnexal diseases; auto-inflammatory dermatoses; acne; contact dermatitis; scleroderma

Special Issue Information

Dear Colleagues,

The growing interest in the pathogenesis of immune-mediated skin diseases (skin IMIDs) has led to the identification of several inflammatory pathways crucial for their development and maintenance.

Fortunately, research in recent years has led to highly effective new treatment options, while further options are expected to be unveiled in the near future. However, open questions remain: What are the main pathological drivers of skin IMIDs? What is the role of the skin microenvironment? What are the mechanisms underlying the systemic involvement in skin IMIDs? Are there predictive biomarkers for systemic targeted treatments? Can an early therapeutic intervention really change the natural history of skin IMIDs and their systemic repercussions? This Special Issue intends to provide plausible answers to these and other questions by tracing the latest "state of the art" advances in skin IMID based on clinical research. Moreover, this issue aims to highlight the current research gaps in order to effectively guide future studies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: psoriasis, atopic dermatitis, acne, rosacea, lichen sclerosus, suppurativa hidradenitis, autoinflammatory skin diseases, systemic sclerosis, allergic contact eczema, chronic spontaneous urticaria, bullous diseases, and chronic graft versus host diseases.

Dr. Anna Campanati
Dr. Emanuela Emanuela Martina
Dr. Giulia Radi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune-mediated skin diseases
  • psoriasis
  • suppurative hidradenitis
  • atopic dermatitis
  • acne vulgaris
  • acne rosacea
  • lichen sclerosus
  • chronic spontaneous urticaria
  • allergic contact eczema
  • neutrophilic dermatoses
  • systemic sclerosis
  • bullous diseases
  • chronic graft versus host diseases

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Published Papers (5 papers)

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Research

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15 pages, 1694 KiB  
Communication
The miR-20a/miR-92b Profile Is Associated with Circulating γδ T-Cell Perturbations in Mild Psoriasis
by Stana Tokić, Maja Jirouš, Vera Plužarić, Martina Mihalj, Marija Šola, Maja Tolušić Levak, Kristina Glavaš, Peter Balogh and Mario Štefanić
Int. J. Mol. Sci. 2023, 24(5), 4323; https://doi.org/10.3390/ijms24054323 - 21 Feb 2023
Viewed by 2211
Abstract
Psoriasis vulgaris (PV) is an autoinflammatory dermatosis of unknown etiology. Current evidence suggests a pathogenic role of γδT cells, but the growing complexity of this population has made the offending subset difficult to pinpoint. The work on γδTCRint and γδTCRhi subsets, [...] Read more.
Psoriasis vulgaris (PV) is an autoinflammatory dermatosis of unknown etiology. Current evidence suggests a pathogenic role of γδT cells, but the growing complexity of this population has made the offending subset difficult to pinpoint. The work on γδTCRint and γδTCRhi subsets, which express intermediate and high levels of γδTCR at their surface, respectively, is particularly scarce, leaving their inner workings in PV essentially unresolved. We have shown here that the γδTCRint/γδTCRhi cell composition and their transcriptom are related to the differential miRNA expression by performing a targeted miRNA and mRNA quantification (RT-qPCR) in multiplexed, flow-sorted γδ blood T cells from healthy controls (n = 14) and patients with PV (n = 13). A significant loss of miR-20a in bulk γδT cells (~fourfold decrease, PV vs. controls) largely mirrored increasing Vδ1-Vδ2- and γδintVδ1-Vδ2- cell densities in the bloodstream, culminating in a relative excess of γδintVδ1-Vδ2- cells for PV. Transcripts encoding DNA-binding factors (ZBTB16), cytokine receptors (IL18R1), and cell adhesion molecules (SELPLG) were depleted in the process, closely tracking miR-20a availability in bulk γδ T-cell RNA. Compared to controls, PV was also associated with enhanced miR-92b expression (~13-fold) in bulk γδT cells that lacked association with the γδT cell composition. The miR-29a and let-7c expressions remained unaltered in case–control comparisons. Overall, our data expand the current landscape of the peripheral γδT cell composition, underlining changes in its mRNA/miRNA transcriptional circuits that may inform PV pathogenesis. Full article
(This article belongs to the Special Issue Novel Molecular Research in Skin Inflammation)
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14 pages, 2422 KiB  
Article
Assessment of Inflammation in 3D Reconstructed Human Skin Exposed to Combined Exposure to Ultraviolet and Wi-Fi Radiation
by Zsófia Szilágyi, Zsuzsanna Németh, József Bakos, Györgyi Kubinyi, Péter Pál Necz, Erika Szabó, György Thuróczy, Rosanna Pinto and Brahim Selmaoui
Int. J. Mol. Sci. 2023, 24(3), 2853; https://doi.org/10.3390/ijms24032853 - 2 Feb 2023
Cited by 7 | Viewed by 2486
Abstract
In the human environment, the increasing exposure to radiofrequency (RF) radiation, especially that emitted by wireless devices, could be absorbed in the body. Recently, mobile and emerging wireless technologies (UMTS, DECT, LTE, and Wi-Fi) have been using higher frequencies than 2G GSM systems [...] Read more.
In the human environment, the increasing exposure to radiofrequency (RF) radiation, especially that emitted by wireless devices, could be absorbed in the body. Recently, mobile and emerging wireless technologies (UMTS, DECT, LTE, and Wi-Fi) have been using higher frequencies than 2G GSM systems (900/1800 MHz), which means that most of the circulating RF currents are absorbed into the skin and the superficial soft tissue. The harmful genotoxic, cytotoxic, and mutagenic effects of solar ultraviolet (UV) radiation on the skin are well-known. This study aimed at investigating whether 2422 MHz (Wi-Fi) RF exposure combined with UV radiation in different sequences has any effect on the inflammation process in the skin. In vitro experiments examined the inflammation process by cytokines (IL-1α, IL-6, IL-8) and MMP-1 enzyme secretion in a 3D full-thickness human skin model. In the first study, UV exposure was immediately followed by RF exposure to measure the potential additive effects, while in the second study, the possible protective phenomenon (i.e., adaptive response) was investigated when adaptive RF exposure was challenged by UV radiation. Our results suggest that 2422 MHz Wi-Fi exposure slightly, not significantly increased cytokine concentrations of the prior UV exposure. We could not detect the adaptive response phenomenon. Full article
(This article belongs to the Special Issue Novel Molecular Research in Skin Inflammation)
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Review

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15 pages, 621 KiB  
Review
miRNAs, Mesenchymal Stromal Cells and Major Neoplastic and Inflammatory Skin Diseases: A Page Being Written: A Systematic Review
by Mariangela Di Vincenzo, Federico Diotallevi, Silvia Piccirillo, Gianluca Carnevale, Annamaria Offidani, Anna Campanati and Monia Orciani
Int. J. Mol. Sci. 2023, 24(10), 8502; https://doi.org/10.3390/ijms24108502 - 9 May 2023
Cited by 1 | Viewed by 2087
Abstract
Micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA) and typically interact with specific target mRNAs through complementary base pairing, affecting their translation and/or stability. MiRNAs regulate nearly all cellular functions, including the cell fate of mesenchymal stromal cells (MSCs). It is [...] Read more.
Micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA) and typically interact with specific target mRNAs through complementary base pairing, affecting their translation and/or stability. MiRNAs regulate nearly all cellular functions, including the cell fate of mesenchymal stromal cells (MSCs). It is now accepted that various pathologies arise at the stem level, and, in this scenario, the role played by miRNAs in the fate of MSCs becomes of primary concern. Here we have considered the existing literature in the field of miRNAs, MSCs and skin diseases, classified as inflammatory (such as psoriasis and atopic dermatitis-AD) and neoplastic (melanoma and non-melanoma-skin-cancer including squamous cell and basal cell carcinoma) diseases. In this scoping review article, the evidence recovered indicates that this topic has attracted attention, but it is still a matter of opinion. A protocol for this review was registered in PROSPERO with the registration number “CRD42023420245”. According to the different skin disorders and to the specific cellular mechanisms considered (cancer stem cells, extracellular vesicles, inflammation), miRNAs may play a pro- or anti-inflammatory, as well as a tumor suppressive, or supporting, role, indicating a complex regulation of their function. It is evident that the mode of action of miRNAs is more than a switch on–off, and all the observed effects of their dysregulated expression must be checked in a detailed analysis of the targeted proteins. The involvement of miRNAs has been studied mainly for squamous cell carcinoma and melanoma, and much less in psoriasis and AD; different mechanisms have been considered, such as miRNAs included in extracellular vesicles derived both from MSCs or tumor cells, miRNAs involved in cancer stem cells formation, up to miRNAs as candidates to be new therapeutic tools. Full article
(This article belongs to the Special Issue Novel Molecular Research in Skin Inflammation)
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25 pages, 851 KiB  
Review
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases
by Albert Stec, Mariusz Sikora, Magdalena Maciejewska, Karolina Paralusz-Stec, Milena Michalska, Ewa Sikorska and Lidia Rudnicka
Int. J. Mol. Sci. 2023, 24(4), 3494; https://doi.org/10.3390/ijms24043494 - 9 Feb 2023
Cited by 23 | Viewed by 5702
Abstract
Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There are three main groups of metabolites: short-chain fatty acids (SCFAs), tryptophan metabolites, [...] Read more.
Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There are three main groups of metabolites: short-chain fatty acids (SCFAs), tryptophan metabolites, and amine derivatives including trimethylamine N-oxide (TMAO). Each group has its own uptake and specific receptors through which these metabolites can exert their systemic function. This review provides up-to-date knowledge about the impact that these groups of gut microbiota metabolites may have in dermatological conditions. Special attention is paid to the effect of microbial metabolites on the immune system, including changes in the profile of the immune cells and cytokine disbalance, which are characteristic of several dermatological diseases, especially psoriasis and atopic dermatitis. Targeting the production of microbiota metabolites may serve as a novel therapeutic approach in several immune-mediated dermatological diseases. Full article
(This article belongs to the Special Issue Novel Molecular Research in Skin Inflammation)
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12 pages, 2022 KiB  
Review
Mesenchymal Stem Cells and Psoriasis: Systematic Review
by Federico Diotallevi, Mariangela Di Vincenzo, Emanuela Martina, Giulia Radi, Vincenzo Lariccia, Annamaria Offidani, Monia Orciani and Anna Campanati
Int. J. Mol. Sci. 2022, 23(23), 15080; https://doi.org/10.3390/ijms232315080 - 1 Dec 2022
Cited by 7 | Viewed by 3572
Abstract
Mesenchymal Stem Cells (MSCs) are multipotent non-hematopoietic stromal cells found in different body tissues such as bone marrow, adipose tissue, periosteum, Wharton’s jelly, umbilical cord, blood, placenta, amniotic fluid, and skin. The biological behavior of MSCs depends mainly on their interaction with the [...] Read more.
Mesenchymal Stem Cells (MSCs) are multipotent non-hematopoietic stromal cells found in different body tissues such as bone marrow, adipose tissue, periosteum, Wharton’s jelly, umbilical cord, blood, placenta, amniotic fluid, and skin. The biological behavior of MSCs depends mainly on their interaction with the microenvironment in which they are found, whose quality deeply influences the regenerative and immunomodulatory properties of these cells. Several studies confirm the interaction between MSCs and inflammatory microenvironment in the pathogenesis of psoriasis, designating MSCs as an important factor driving psoriasis development. This review aims to describe the most recent evidence on how the inflammatory microenvironment that characterizes psoriasis influences the homeostasis of MSCs and how they can be used to treat the disease. Full article
(This article belongs to the Special Issue Novel Molecular Research in Skin Inflammation)
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