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Development and Biomedical Application of Novel Nano-Drug Delivery System

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2827

Special Issue Editor


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Guest Editor
Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria
Interests: magnetic nanoparticles; iron oxides; characterization; bio-nano-interactions; nanomaterials
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Special Issue Information

Dear Colleagues,

Nanotechnology is transforming medical research, especially in developing tiny drug delivery systems known as nano-DDS. This exciting area of nanomedicine uses the precision of tiny particles to deliver drugs right where they are needed, offering new hope for treating chronic illnesses and cancer. Nanoparticles, including liposomes, micelles, extracellular vesicles, virus-like particles and dendrimers, are at the forefront of this change, making treatments more effective and less harmful to the body. This Special Issue focuses on the characterization of these nanocarriers and the encapsulation of drugs for medical treatments.

The scope of nanomedicine extends to combating prevalent conditions like cardiovascular diseases or cancer therapy with ongoing research continually refining nanocarrier design and therapeutic strategies; this fosters the development of tailored medical interventions that redefine healthcare boundaries. Reports on innovative methods for synthesis formulation of drug nanocarriers and novel encapsulation strategies, characterization, and applications of the systems should contribute to this Special Issue.

The Special Issue is led by Dr. Sebastian Schwaminger and assisted by his Postdoc, Dr. Marco Eigenfeld (Technical University of Munich).

Dr. Sebastian Schwaminger
Guest Editor

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Keywords

  • nanotechnology
  • drug delivery systems
  • nanomedicine
  • nanocarriers
  • drug nanocarriers

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Published Papers (2 papers)

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Research

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11 pages, 4986 KiB  
Article
Gelatin-Coated TiO2/Pd Hybrid: A Potentially Useful Nanomaterial to Enhance Antibacterial and Anticancer Properties
by Periasamy Anbu, Muruganantham Rethinasabapathy, Anbazhagan Sathiyaseelan, Xin Zhang, Myeong-Hyeon Wang, Sekar Vijayakumar and Yun Suk Huh
Int. J. Mol. Sci. 2024, 25(10), 5308; https://doi.org/10.3390/ijms25105308 - 13 May 2024
Cited by 1 | Viewed by 1248
Abstract
Hybrid nanomaterials have attracted considerable interest in biomedicine because of their fascinating characteristics and wide range of applications in targeted drug delivery, antibacterial activity, and cancer treatment. This study developed a gelatin-coated Titanium oxide/palladium (TiO2/Pd) hybrid nanomaterial to enhance the antibacterial [...] Read more.
Hybrid nanomaterials have attracted considerable interest in biomedicine because of their fascinating characteristics and wide range of applications in targeted drug delivery, antibacterial activity, and cancer treatment. This study developed a gelatin-coated Titanium oxide/palladium (TiO2/Pd) hybrid nanomaterial to enhance the antibacterial and anticancer capabilities. Morphological and structural analyses were conducted to characterize the synthesized hybrid nanomaterial. The surface texture of the hybrid nanomaterials was examined by high-resolution transmission electron microscopy (HR-TEM) and field-emission scanning electron microscopy (FE-SEM). The FE-SEM image revealed the bulk of the spherically shaped particles and the aggregated tiny granules. Energy dispersive X-ray spectroscopy (EDS) revealed Ti, Pd, C, and O. X-ray diffraction (XRD) revealed the gelatin-coated TiO2/Pd to be in the anatase form. Fourier transform infrared spectroscopy examined the interactions among the gelatin-coated TiO2/Pd nanoparticles. The gelatin-coated TiO2/Pd nanomaterials exhibited high antibacterial activity against Escherichia coli (22 mm) and Bacillus subtilis (17 mm) compared to individual nanoparticles, confirming the synergistic effect. More importantly, the gelatin-coated TiO2/Pd hybrid nanomaterial exhibited remarkable cytotoxic effects on A549 lung cancer cells which shows a linear increase with the concentration of the nanomaterial. The hybrid nanomaterials displayed higher toxicity to cancer cells than the nanoparticles alone. Furthermore, the cytotoxic activity against human cancer cells was verified by the generation of reactive oxygen species and nuclear damage. Therefore, gelatin-coated TiO2/Pd nanomaterials have potential uses in treating cancer and bacterial infections. Full article
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Review

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17 pages, 1664 KiB  
Review
Intrathecal Immunoselective Nanopheresis for Alzheimer’s Disease: What and How? Why and When?
by Manuel Menendez-Gonzalez
Int. J. Mol. Sci. 2024, 25(19), 10632; https://doi.org/10.3390/ijms251910632 - 2 Oct 2024
Viewed by 755
Abstract
Nanotechnology is transforming therapeutics for brain disorders, especially in developing drug delivery systems. Intrathecal immunoselective nanopheresis with soluble monoclonal antibodies represents an innovative approach in the realm of drug delivery systems for Central Nervous System conditions, especially for targeting soluble beta-amyloid in Alzheimer’s [...] Read more.
Nanotechnology is transforming therapeutics for brain disorders, especially in developing drug delivery systems. Intrathecal immunoselective nanopheresis with soluble monoclonal antibodies represents an innovative approach in the realm of drug delivery systems for Central Nervous System conditions, especially for targeting soluble beta-amyloid in Alzheimer’s disease. This review delves into the concept of intrathecal immunoselective nanopheresis. It provides an overall description of devices to perform this technique while discussing the nanotechnology behind its mechanism of action, its potential advantages, and clinical implications. By exploring current research and advancements, we aim to provide a comprehensive understanding of this novel method, addressing the critical questions of what it is, how it works, why it is needed, and when it should be applied. Special attention is given to patient selection and the optimal timing for therapy initiation in Alzheimer’s, coinciding with the peak accumulation of amyloid oligomers in the early stages. Potential limitations and alternative targets beyond beta-amyloid and future perspectives for immunoselective nanopheresis are also described. Full article
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