Signaling Pathways in Neuroinflammation or Neurodegenerative Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 42
Special Issue Editor
Interests: oxidative stress; nutrition; cell physiology; animal model; inflammation; molecular pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research into neurodegenerative illnesses, such as Huntington's, Parkinson's, and Alzheimer's disease and amyotrophic lateral sclerosis, has revealed that inflammation plays a critical role in the process of neurodegeneration in addition to being a symptom of it. Protein aggregates, a prevalent pathogenic feature in neurodegeneration, can trigger neuroinflammation, exacerbating both the neurodegenerative process and the protein aggregates. In fact, inflammation occurs even before the aggregation of proteins. For instance. certain susceptible populations may experience protein deposition as a result of neuroinflammation brought on by genetic differences in CNS cells or by peripheral immune cells. Though they are still far from being fully understood, a variety of CNS cells and a number of signaling pathways have been implicated in the etiology of neurodegeneration. This Special Issue aims to provide a thorough overview of the variables influencing neuroinflammation and the main inflammatory signaling pathways implicated in the pathophysiology of neurodegenerative illnesses. In vitro and in vivo investigations are welcome as well as clinical studies that provide compelling scientific evidence for the effectiveness of novel molecular mechanisms limiting the onset of neurodegenerative disorders.
Dr. Marika Cordaro
Guest Editor
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Keywords
- inflammation
- neuroinflammation
- oxidative stress
- neurodegenerative disorders
- pathology
- molecular pathways
- dysregulation
- mitochondrial dysfunction
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