Redox Homeostasis and Antioxidant Strategies in the Pathophysiology

Dear Colleagues,

Oxidative stress is frequently described as the balance between the production of reactive species, including oxygen and nitrogen, in biological systems and the ability of the latter to defend through sophisticated antioxidant machinery. Nevertheless, when oxidants are produced in excess, or when the antioxidant defenses that regulate them are ineffective, this balance can be perturbed, thus resulting in oxidative conditions, associated with chronic pathogenesis diseases. A certain amount of oxidative stress is useful to the body for growth and cell signaling, but excess levels, produced by several endogenous and exogenous processes, have deleterious effects on cell components including proteins lipids and nucleic acids and alter the redox status of the cell. Antioxidants may protect against cell damage during oxidative stress. New research showed that natural antioxidants in foods have commonly belonged to better health and life quality. Dietary or natural antioxidants play an important role in helping endogenous antioxidants in scavenging excess free radicals. Antioxidant supplements include several important substances (carotenoids, polyphenols, phycocyanin and flavonoids), which are rich in vegetables, fruits and natural foods.
This Special Issue will focus on the investigation of the molecular mechanisms underlying oxidative stress, and pathophysiological consequences in cell and tissue function, in order to open new avenues in therapy. To this aim, the beneficial effects of antioxidants and possible mechanisms of cell adaptation in the context of the imbalance of chronic oxidative-related diseases will be worthy of note. It welcomes manuscripts collecting and contributing to the dissemination of high-quality research articles, as well as review articles, focusing on the relationship between oxidative stress and cellular responses in chronic diseases. In addition, molecular targets of cellular membranes, as well as their potential modulation under oxidative stress will be also considered, in an attempt to provide more information about cell response to oxidative stress and its possible modulation by novel antioxidant strategies. Studies using animal or cell models, as well as clinical studies are welcomed.

Potential topics include but are not limited to the following:

• Human health and diseases
• Cellular response to oxidative stress
• Oxidative stress and related cell signaling
• Cell adaptation to oxidative stress
• Biomarkers of oxidative stress in diseases
• Beneficial effects of natural or synthetic antioxidants in oxidative stress-related diseases
• Aging

Dr. Alessia Remigante
Dr. Rossana Morabito
Dr. Marika Cordaro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.