Prevention and Drug Treatment of Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 27174
Special Issue Editor
Interests: natural product; therapeutics; health promotion; nutraceuticals; metabolomics; medicinal chemistry; innovative technology (artificial intelligence and machine learning)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer is the most diagnosed type of cancer in women, and it has the second highest mortality rate in this group, following only lung cancer. Every year, an estimated 1–1.3 million breast cancer cases are diagnosed worldwide. Of these, approximately 15–20% of breast cancers in women are triple-negative breast cancer (TNBC), which is considered to be more aggressive and is often diagnosed in patients younger than 50 years old. Other types of breast cancer are more commonly diagnosed in people aged 60 or older. In addition to young women, TNBC disproportionately affects women of African and Hispanic descent than women of Caucasian descent. Asian women and non-Hispanic white women are less likely to be diagnosed with this type of cancer. Family history is a well-recognized and established risk factor for aggressive breast cancer. For example, about 70% of breast cancers diagnosed in people with an inherited BRCA mutation, particularly BRCA1, are triple-negative breast cancer. Other factors, such as environmental exposure to mixtures of chemicals, have been linked to an increased incidence of breast cancer in the United States and, in particular, among minority populations. Although family history (hereditary) risk factors associated with breast cancer are not modifiable, lifestyle and some environmental factors can be modified and prevented. A healthy lifestyle can be achieved by keeping a normal body weight, eating well or consuming a high amount of vegetables and fruit, lowering blood pressure, managing stress, maintaining enough physical activity, minimizing alcohol intake, quitting cigarette smoking, and reducing second-hand smoke exposure.
National Cancer Institute (NCI)-supported research has indicated that aggressive breast tumors are more common in younger African American and Hispanic women living in low socioeconomic status areas. This more aggressive form of breast cancer is less responsive to standard cancer treatments and is associated with a lower survival rate. The treatment of aggressive breast cancer remains a critical challenge in the medical community, because there are no targeted therapies and the prognosis remains modest. Moreover, there is an urgent need for the discovery and development of agent(s) efficacious to treat aggressive breast cancer. Studies have shown that there are alternative treatments to conventional drugs that might be effective in the management of TNBC. The peer-reviewed articles published in this Special Issue will highlight the drug treatment of breast cancer. In addition, this Special Issue will address the issues of preventive measures for breast cancer. When considering your submission, please keep in mind that IJMS is a journal of molecular science.
Dr. Clement G. Yedjou
Guest Editor
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Keywords
- breast cancer
- drug treatment
- traditional medicine
- natural product
- prevention
- treatment
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