Sirtuins in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 39333
Special Issue Editors
Interests: cardiovascular disease; heart failure; diabetes; cardiac energy metabolism
Special Issue Information
Dear Colleagues,
The discovery and characterization of sirtuins as NAD+-dependent deacylases have revolutionized our understanding of post-translational protein regulation. In fact, numerous post-translational modifications have been attributed to the activity of different sirtuins with distinct cellular localization, and recent findings have advanced our knowledge of the importance of sirtuin-catalyzed posttranslational modifications in health and disease. Sirtuins have been identified as major regulators of a variety of fundamental intracellular pathways and, thus, play a critical role in aging, energy metabolism, and in the adaptation to cellular stressors. That said, sirtuins have been implicated in the pathology of age-related maladies, including cancer, diabetes, and neurodegenerative or cardiovascular diseases, mostly mediating protective effects upon activation. Of note, clinical trials have been initiated to evaluate the therapeutic potential of sirtuin activation.
This Special Issue in the International Journal of Molecular Sciences aims at presenting contemporary research on the role of sirtuins both in health and disease, which shall include research in different organisms and models, and can spread across the entirety of cellular physiology and organ disease. We cordially invite you to submit original articles, review articles, methodological papers, as well as studies related to clinical cases. We encourage researchers to address the current knowledge as well as existing controversies, or present outstanding questions and new concepts related to sirtuins and NAD+ metabolism.
Dr. Heiko Bugger
Dr. Simon Sedej
Guest Editors
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Keywords
- Caloric restriction
- Aging
- NAD+ metabolism
- Sirtuin
- Acetylation
- Metabolic disease
- Longevity
- Posttranslational modification
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