Carbonic Anhydrase and Biomarker Research 2022
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (1 August 2023) | Viewed by 3084
Special Issue Editor
Interests: carbonic anhydrase; antioxidant; biomarkers; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous series of Special Issues “Carbonic Anhydrase and Biomarker Research”, “Carbonic Anhydrase and Biomarker Research 2020” and “Carbonic Anhydrase and Biomarker Research 2021”.
Carbonic anhydrase is a widely distributed metalloenzyme catalysing the reversible hydration of CO2 to HCO3- and H+. It plays a fundamental role in a number of physiological processes, including gas exchange, pH homeostasis, electrolyte transport, metabolic reactions, bone resorption and calcification. Recently, its involvement in several pathological conditions, as well as sensitivity to chemical pollutants, has advanced the research on carbonic anhydrase in the biomarker discovery field.
A biomarker is defined as a cellular, biochemical or molecular alteration that is measurable in biological media as an indicator of normal biological or pathogenic processes, or a response to an exposure or intervention. Biomarkers are useful tools in a wide range of fields, including medicine, drug discovery, environmental health and ecotoxicology.
In recent years, alterations in the expression of specific carbonic anhydrase isoforms have been proposed as diagnostic or prognostic biomarkers in the clinical field, mainly in cancer research.
Moreover, the sensitivity of specific carbonic anhydrase isoforms to environmental pollutants has given rise to new perspectives in the potential use of carbonic anhydrase as a pollution biomarker.
This Special Issue of IJMS is aimed to cover the more recent insights into the research of carbonic anhydrase as a promising biomarker in several areas of interest, from human health to environmental sciences, opening new perspectives for the translation of advances in basic sciences on this ancient enzyme into innovative applications.
Dr. Maria Giulia Lionetto
Guest Editor
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Keywords
- carbonic anhydrase
- biomarker
- pH regulation
- cancer
- tumor microenvironment
- heavy metals
- pollutant
- biomonitoring
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