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Oxidative Stress and Genotoxicity: New Insights in 2022
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Oxidative Stress and Genotoxicity: New Insights in 2022

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (30 January 2023) | Viewed by 7903

Special Issue Editor

Dr. Maria Giulia Lionetto

E-Mail Website
Guest Editor
Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Itay
Interests: carbonic anhydrase; antioxidant; biomarkers; oxidative stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to submit your valuable research outcomes for publication in the Special Issue entitled “Oxidative Stress and Genotoxicity: New Insights in 2022" in the International Journal of Molecular Science (MDPI).

In recent years, a growing body of evidence has highlighted the relationship between genotoxicity, due to the induction of DNA damage by an endogenous or exogenous event, and oxidative stress, which arises from the imbalance between the production and accumulation of reactive species in the cells and the antioxidant defenses. The relationship between oxidative stress and genotoxicity has been recognized to be relevant for the genesis of several pathological conditions, especially cancer diseases.

This Special Issue aims to provide new insights into the molecular and cellular mechanisms underlying oxidative-stress-mediated genotoxicity and to indicate development perspectives.

The paper presented in this issue will be of valuable interest to the scientific community in several research areas, including cell biology, physiopathology, toxicology, etc.

Prof. Dr. Maria Giulia Lionetto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • genotoxicity
  • DNA damage
  • DNA repair
  • reactive species
  • cell signaling
  • cancer
  • assay development

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

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16 pages, 1479 KiB  
Article
Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice
by Tyciane S. Nascimento, Daniel V. Pinto, Ronaldo P. Dias, Ramon S. Raposo, Paulo Iury G. Nunes, Cássia R. Roque, Flávia A. Santos, Geanne M. Andrade, José Lucas Viana, Anne H. Fostier, Alessandra Sussulini, Jacqueline I. Alvarez-Leite, Carlos Fontes-Ribeiro, João O. Malva and Reinaldo B. Oriá
Int. J. Mol. Sci. 2022, 23(22), 13837; https://doi.org/10.3390/ijms232213837 - 10 Nov 2022
Cited by 2 | Viewed by 2177
Abstract
Methylmercury (MeHg) is highly toxic to the human brain. Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects hippocampal amino acids and other neurochemical markers in adult mice. In this study, we evaluated the MeHg effects [...] Read more.
Methylmercury (MeHg) is highly toxic to the human brain. Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects hippocampal amino acids and other neurochemical markers in adult mice. In this study, we evaluated the MeHg effects on systemic lipids and inflammation, hippocampal oxidative stress, amino acid levels, neuroinflammation, and behavior in adult male mice. Challenged mice received MeHg in drinking water (2 mg/L) for 30 days. We assessed weight gain, total plasma cholesterol (TC), triglycerides (TG), endotoxin, and TNF levels. Hippocampal myeloperoxidase (MPO), malondialdehyde (MDA), acetylcholinesterase (AChE), amino acid levels, and cytokine transcripts were evaluated. Mice underwent open field, object recognition, Y, and Barnes maze tests. MeHg-intoxicated mice had higher weight gain and increased the TG and TC plasma levels. Elevated circulating TNF and LPS confirmed systemic inflammation. Higher levels of MPO and MDA and a reduction in IL-4 transcripts were found in the hippocampus. MeHg-intoxication led to increased GABA and glycine, reduced hippocampal taurine levels, delayed acquisition in the Barnes maze, and poor locomotor activity. No significant changes were found in AChE activity and object recognition. Altogether, our findings highlight chronic MeHg-induced effects that may have long-term mental health consequences in prolonged exposed human populations. Full article
(This article belongs to the Special Issue Oxidative Stress and Genotoxicity: New Insights in 2022)
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Review

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14 pages, 772 KiB  
Review
Ionophore Toxicity in Animals: A Review of Clinical and Molecular Aspects
by İlksen Berfin Ekinci, Agnieszka Chłodowska and Małgorzata Olejnik
Int. J. Mol. Sci. 2023, 24(2), 1696; https://doi.org/10.3390/ijms24021696 - 15 Jan 2023
Cited by 22 | Viewed by 4953
Abstract
For many years, ionophores have been used to control coccidiosis in poultry. However, misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical factors influencing ionophores’ toxicity are administration dose, species, and animal age. Although clinical signs of ionophore intoxication [...] Read more.
For many years, ionophores have been used to control coccidiosis in poultry. However, misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical factors influencing ionophores’ toxicity are administration dose, species, and animal age. Although clinical signs of ionophore intoxication are well studied, the toxicity mechanisms of the ionophores at the molecular level still are not fully elucidated. This review summarizes the studies focused on polyether ionophores toxicity mechanisms in animals at the clinical and molecular levels. Studies show that ionophore toxicity mainly affects myocardial and skeletal muscle cells. The molecular mechanism of the toxication could be explained by the inhibition of oxidative phosphorylation via dysregulation of ion concentration. Tiamulin-ionophore interaction and the synergetic effect of tiamulin in ionophore biotransformation are discussed. Furthermore, in recent years ionophores were candidates for reprofiling as antibacterial and anti-cancer drugs. Identifying ionophores’ toxicity mechanisms at the cellular level will likely help develop novel therapies in veterinary and human medicine. Full article
(This article belongs to the Special Issue Oxidative Stress and Genotoxicity: New Insights in 2022)
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