Molecular Genetics of Tumor Heterogeneity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 9898
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tumor heterogeneity is a major roadblock to the success of targeted cancer treatments. Recent work in this area suggests that treatments have variable effects on tumor subregions and subclones, suggesting that methods to target all tumor subclones are necessary for successful treatment. More research is needed in order to study the genetic, epigenetic, and cellular diversity of cancers and the influence of this diversity on existing and experimental cancer therapies. Moreover, methods to investigate tumor heterogeneity at the point of care, for each individual patient, are needed to supplement other efforts in personalized oncology. In order to advance the field, research progress and new methods and techniques will be required, including new computational models, biopsy techniques, and analysis methods, as well as large-scale studies of tumor heterogeneity. We seek to aggregate contributions that focus on technological and methodological advances related to improving our understanding of tumor heterogeneity, its effects on tumors and therapies, and the potential place of associated technologies within a personalized-oncology toolset.
Prof. Pavel Sumazin
Guest Editor
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