Mechanism of Longevity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 22255
Special Issue Editor
Interests: nerve injury and neuropathic pain; pain and aging; central adaptations to chronic pain; multiple sclerosis; neuroinflammation; neuro-immunologic communication; redox signaling; nitric oxide; endocannabinoids and other lipid signaling molecules; progranulin; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging describes a time-dependent progressive decline of function with increasing age, and the hope for anti-aging strategies or medications has been motivated researchers for ages to unravel the mechanisms. More recently, “longevity”, i.e., maintenance of a long and healthy life, has been recognized as a unique feature, not simply the opposite of aging, but characterized by a positive gain of resource-sparing functions, such as change of enzyme activity, enhancement of the clearance of cellular waste, or adaptations to mild challenges, which increase the resilience towards major stressors. It is particularly intriguing to unravel how sociality and internal reward mechanisms help to extent neuronal life and circuits and hence, the individual’s life.
In the present Special Issue, we invite contributions addressing mechanisms of longevity, including all aspects from genetic, epigenetic, metabolic, endocrine, immune or redox-mediated mechanisms to environmental factors such as nutrition, sleep, social life or exercise. Original research papers and reviews are equally welcome and may involve in vitro and in vivo studies in different cells and organisms. The Special Issue will emphasize common and specific mechanisms adopted by various organisms to maintain a long and healthy life and highlight translational aspects ranging from molecules to human life at old age.
Prof. Dr. Irmgard Tegeder
Guest Editor
Manuscript Submission Information
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Keywords
- longevity
- lifespan
- aging
- survival
- senescence
- old age
- youth
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