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Myocardial Disease: Molecular Pathology and Treatments
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Myocardial Disease: Molecular Pathology and Treatments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1428

Special Issue Editor

Dr. Kazufumi Nakamura

E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Interests: fish oil; postprandial hyperlipidemia; antioxidants; heart failure; hyperlipidemia; atherosclerosis; cardiomyopathy; pulmonary hypertension
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Heart failure is a serious disease that is increasing worldwide. The diagnosis and treatment of myocardial diseases such as cardiomyopathy and myocarditis, which are among the causative diseases of heart failure, are important. Recent advances in molecular and cellular biological understandings of the causes and pathophysiology of these diseases have led to the development of diagnostic methods and specific treatments.

Treatment methods based on the pathophysiology of hypertrophic cardiomyopathy, Fabry disease, and amyloidosis have been proposed and implemented in practice. Further developments in diagnostic and therapeutic methods in various cardiomyopathies, such as dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, are expected in the future. In myocarditis and sarcoidosis, the involvement of immunity and cytokines is being elucidated, and further therapeutic advances are expected in the future. The development of tailor-made medicine based on genetic abnormalities and differences in immune and inflammatory mechanisms is awaited.

This Special Issue entitled “Myocardial Disease: Molecular Pathology and Treatments” welcomes original research and reviews of the literature concerning this important topic. Since IJMS is a journal of molecular science, pure clinical or model studies will not suitable for our journal. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Kazufumi Nakamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypertrophic cardiomyopathy
  • dilated cardiomyopathy
  • arrhythmogenic right ventricular cardiomyopathy
  • amyloidosis
  • myocarditis
  • sarcoidosis
  • genetic abnormalities
  • immune mechanisms

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Published Papers (2 papers)

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21 pages, 22278 KiB  
Article
Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study
by Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Keiichi Hirono and Naoki Nishida
Int. J. Mol. Sci. 2024, 25(15), 8176; https://doi.org/10.3390/ijms25158176 - 26 Jul 2024
Viewed by 779
Abstract
Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, [...] Read more.
Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, including both sides of atria and atrial appendages, was evaluated semiquantitatively. Using digital pathology, we quantitatively evaluated the immunohistochemical deposition burden of ATTR in the myocardium. We identified 20 sporadic ATTR cardiac amyloidosis cases (nine males). All patients had ATTR deposition in the left atrial regions of the myocardium. In the semiquantitative analysis, 14 of the 20 cases showed more severe ATTR deposition on the left atrial regions than on the right side, with statistically significant differences in the pathology grading (p < 0.01 for both the atrium and atrial appendage). Quantitative analysis further supported the difference. Moreover, six had ATTR deposition in the epineurium and/or neural fibers of the atria. Cluster analysis revealed that ATTR deposition in the myocardium was significantly more severe in males than in females. The heterogeneous distribution of amyloid deposits between atria revealed in this study may impair the orderly transmission of the cardiac conduction system and induce arrhythmias, which may be further aggravated by additional neuropathy in the advanced phase. This impairment could be more severe among males. These findings emphasize that atrial evaluation is important for individuals with sporadic ATTR cardiac amyloidosis, particularly for early detection. Full article
(This article belongs to the Special Issue Myocardial Disease: Molecular Pathology and Treatments)
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8 pages, 676 KiB  
Case Report
Troponin Test, Not Only a Number: An Unusual Case of False Positive
by Michela Salvatici, Monica Gaimarri, Francesca Rispoli, Barbara Bianchi, Delia Francesca Sansico, Eleonora Matteucci, Andrea Antonelli, Francesco Bandera and Lorenzo Drago
Int. J. Mol. Sci. 2024, 25(22), 11937; https://doi.org/10.3390/ijms252211937 - 6 Nov 2024
Viewed by 337
Abstract
Heterophile antibodies, which can arise from infections, autoimmune disorders, or exposure to animal antigens, can interfere with immunoassays. These antibodies can cross-react with the test reagents used in troponin assays, causing a false elevation in troponin levels. The paper describes a case of [...] Read more.
Heterophile antibodies, which can arise from infections, autoimmune disorders, or exposure to animal antigens, can interfere with immunoassays. These antibodies can cross-react with the test reagents used in troponin assays, causing a false elevation in troponin levels. The paper describes a case of a 37-year-old male drug abuser admitted to the emergency room with chest pain. A series of troponin measurements performed using different assays gave discrepant results. Only thanks to the use of Scantibodies HBT tubes, which remove heterophile antibodies, was it possible to make a correct diagnosis of troponin negativity. In conclusion, a correct laboratory/clinical approach to the identification of heterophile antibody interference is essential for accurate troponin testing in order to avoid false positive results. Implementing neutralizing tests can significantly improve the reliability of these diagnostic assays, ensuring better patient outcome. Full article
(This article belongs to the Special Issue Myocardial Disease: Molecular Pathology and Treatments)
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