nutrients-logo

Journal Browser

Journal Browser

Iron Deficiency in Human Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 5 February 2025 | Viewed by 840

Special Issue Editor

Special Issue Information

Dear Colleagues,

Iron is required by all organ systems for a variety of metabolic processes, including erythropoiesis, mitochondrial function, oxygen transport, cardiac and skeletal muscle metabolism, immune and nervous systems, inflammatory responses, and the lipid metabolism. However, iron deficiency is common worldwide and has been reported to be common in women, children and athletes, as well as, more recently, in patients with cardiovascular diseases such as coronary artery disease, heart failure, and pulmonary hypertension.

In this Special Issue, we aim to gather together a wide range of papers on the causes, pathophysiology, and treatment of iron deficiency. We also seek to clarify the impact of iron deficiency on human health and disease, and make a small but significant contribution to improving the health of people worldwide.

This Special Issue of Nutrients entitled “Iron Deficiency on Human Health and Disease” welcomes original research and reviews of the literature concerning this important topic.

Dr. Kazufumi Nakamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • erythropoiesis
  • mitochondrial function
  • immune systems
  • nervous systems
  • inflammatory response
  • cardiovascular disease
  • heart failure
  • coronary artery disease
  • pulmonary hypertension

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 611 KiB  
Article
Associations Between Hemoglobin and Serum Iron Levels and the Risk of Mortality Among Patients with Coronary Artery Disease
by Qing Li, Zhijun Pan, Yupeng Zeng, Xu Wang, Dan Li, Ting Yin, Qian Chen and Wenhua Ling
Nutrients 2025, 17(1), 139; https://doi.org/10.3390/nu17010139 - 31 Dec 2024
Viewed by 545
Abstract
Background: This study aimed to investigate the relationship between hemoglobin and serum iron levels and mortality risk in patients with coronary artery disease (CAD). Methods: We analyzed data from 3224 patients with CAD using Cox proportional hazards regression models to assess the association [...] Read more.
Background: This study aimed to investigate the relationship between hemoglobin and serum iron levels and mortality risk in patients with coronary artery disease (CAD). Methods: We analyzed data from 3224 patients with CAD using Cox proportional hazards regression models to assess the association of hemoglobin and serum iron levels with cardiovascular and all-cause mortality from the Guangdong coronary artery disease cohort. Results: Over a median follow-up period of 8.9 years, 636 patients died, including 403 from cardiovascular causes. Higher hemoglobin and serum iron levels were linked to a reduced risk of cardiovascular and all-cause mortality. Patients in the highest quartiles of hemoglobin and serum iron levels had multivariable-adjusted hazard ratios (HRs) of 0.62 (95% CI, 0.46–0.85) and 0.51 (95% CI, 0.37–0.69) for cardiovascular mortality and 0.64 (95% CI, 0.50–0.83) and 0.67 (95% CI, 0.53–0.85) for all-cause mortality, compared with those in the lowest quartile. A one-standard-deviation increase in hemoglobin and serum iron levels corresponded to a 19% and 24% reduction in cardiovascular mortality risk and a 19% reduction in all-cause mortality risk for both factors. Restricted cubic spline analysis revealed L-shaped and U-shaped associations between hemoglobin and serum iron levels and cardiovascular and all-cause mortality, respectively. Conclusions: Hemoglobin and serum iron levels were significantly associated with lower risks of cardiovascular and all-cause mortality in patients with CAD. Further research is needed to evaluate the effects of iron supplementation in these patients. Full article
(This article belongs to the Special Issue Iron Deficiency in Human Health and Disease)
Show Figures

Figure 1

Back to TopTop