New Receptor Molecules: Design, Obtaining and Analytical Use
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 16402
Special Issue Editor
Special Issue Information
Dear Colleagues,
The use of biomolecules as receptors in analytical systems provides the possibility for simple and selective detection of target ligands. Many kits and sensors have been developed with the use of antibodies, aptamers, and other classes of receptor molecules. However, traditional techniques to obtain receptors, such as immunization for antibodies and SELEX for aptamers, have fundamental features that limit their applications for the obtained receptor molecules. Selected in vivo or in vitro receptors often have low binding constants or show cross-reactivity towards several structurally related compounds. To overcome these limitations, in recent years, various approaches have been actively proposed. They are based on the design of target molecules for selection, changes in the methods for obtaining receptors, the use of new combinatorial libraries, theoretical modeling of ligand–receptor complexes. However, these methods have not yet been implemented in mass practice; their capabilities and limitations are evaluated on a few examples that are insufficient to choose the most effective approaches.
The proposed Special Issue is focused on new developments in this direction. Methods for predicting the properties of receptor molecules (their affinity, selectivity, stability under different conditions) and directed production of improved compounds will be the subject of this issue. It is also extremely important to assess the capabilities of new receptor molecules and to improve with their help the characteristics of analytical kits, sensors, and devices used in medical and veterinary diagnostics, environmental monitoring, quality, and safety control of foods and other consumer products.
Dr. Anatoly V Zherdev
Guest Editor
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