Usage of Biopolymers in Medical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 3698

Special Issue Editor


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Guest Editor
Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Interests: drug delivery; polymer synthesis; thermal degradation; release rate; membrane transfer
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Special Issue Information

Dear Colleagues,

I would like to invite you to contribute to Special Issue “Usage of Biopolymers in Medical Applications”.

Organic or inorganic, synthetic or natural polymers are often used in medical applications such as heart valves, artificial skin and kidney, drug delivery systems, bone prostheses, dental adhesives etc. Due to their versatility and other many properties, like haemocompatibility and biodegradability, an increasing number of polymers and copolymers find their applicability in various medical fields in the last decades. The development of biopolymers is nowaday at an enhanced level and the science will not stop here; a good colaboration between the developers of computational models, the synthesists, the researchers who are involved in the physical and mechanical characterization of materials and those interested in the citotoxicity of samples is necessary in order to realize better materials. The present issue aims to gather research and review papers where the attention paid to polymer-based biomaterials and their impact in different medical fields is efficiently integrated.

This Special Issue invites researchers and experts from all over the world to submit original research and reviews on the biopolymers that will bring important data, thus creating databases of great importance for the medical applications. You may send your manuscript, that will be processed on a rolling basis as they are received. We also encourage authors to send a short abstract and tentative title to the Editorial Office in advance ([email protected]).

Journal of Functional Biomaterials is an online open access journal covering biomedical engineering. It is indexed by Scopus, Web of Science, PubMed, PMC, CAPlus / SciFinder, and other databases. and the impact factor is 4.901. For more details about this journal, please refer to the links at https://www.mdpi.com/journal/jfb

We look forward to collaborating with you in near future.

Dr. Florin Borcan
Guest Editor

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Keywords

  • drug carrier
  • nanocapsules
  • nanostructures
  • macromolecule
  • prostheses
  • adhesives

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Published Papers (1 paper)

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14 pages, 2577 KiB  
Article
A Silicon-Based PDMS-PEG Copolymer Microfluidic Chip for Real-Time Polymerase Chain Reaction Diagnosis
by Siyu Yang, Qingyue Xian, Yiteng Liu, Ziyi Zhang, Qi Song, Yibo Gao and Weijia Wen
J. Funct. Biomater. 2023, 14(4), 208; https://doi.org/10.3390/jfb14040208 - 9 Apr 2023
Cited by 2 | Viewed by 3380
Abstract
Polydimethylsiloxane (PDMS) has been widely used to make lab-on-a-chip devices, such as reactors and sensors, for biological research. Real-time nucleic acid testing is one of the main applications of PDMS microfluidic chips due to their high biocompatibility and transparency. However, the inherent hydrophobicity [...] Read more.
Polydimethylsiloxane (PDMS) has been widely used to make lab-on-a-chip devices, such as reactors and sensors, for biological research. Real-time nucleic acid testing is one of the main applications of PDMS microfluidic chips due to their high biocompatibility and transparency. However, the inherent hydrophobicity and excessive gas permeability of PDMS hinder its applications in many fields. This study developed a silicon-based polydimethylsiloxane-polyethylene-glycol (PDMS-PEG) copolymer microfluidic chip, the PDMS-PEG copolymer silicon chip (PPc-Si chip), for biomolecular diagnosis. By adjusting the modifier formula for PDMS, the hydrophilic switch occurred within 15 s after contact with water, resulting in only a 0.8% reduction in transmittance after modification. In addition, we evaluated the transmittance at a wide range of wavelengths from 200 nm to 1000 nm to provide a reference for its optical property study and application in optical-related devices. The improved hydrophilicity was achieved by introducing a large number of hydroxyl groups, which also resulted in excellent bonding strength of PPc-Si chips. The bonding condition was easy to achieve and time-saving. Real-time PCR tests were successfully conducted with higher efficiency and lower non-specific absorption. This chip has a high potential for a wide range of applications in point-of-care tests (POCT) and rapid disease diagnosis. Full article
(This article belongs to the Special Issue Usage of Biopolymers in Medical Applications)
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