Active Biomedical Materials and Their Applications, 2nd Edition

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Guest Editor
Restorative Dental Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China
Interests: bioactive materials; ceramics; polymers; metals; materials characterization; coatings; nanotechnology; antimicrobial agents; resin composites
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Special Issue Information

Dear Colleagues,

Active biomedical materials are designed to interact with biological systems for therapeutic purposes. These materials have various applications, such as in tissue regeneration and repair, implant fixtures, controlled drug delivery, and antimicrobial agents. Synthetic or natural active biomedical materials, such as metals and their alloys, ceramics, composites, and polymers, are used for these purposes. The synthesis and fabrication of active biomedical materials require the use of different methods and technologies.

This Special Issue, "Active Biomedical Materials and Their Applications, 2nd Edition" will continue our focus on the importance of biomedical materials in dentistry and medicine. Its scope covers, but is not limited to, the following topics:

  1. Synthesis and characterization of biomedical materials;
  2. Biomedical materials in tissue regeneration and repair;
  3. Biomedical materials with antimicrobial properties;
  4. Biocompatibility assessments in biomedical materials;
  5. Biomedical materials in dental and medical applications.

We aim to publish articles on current and new active biomedical materials used in healthcare applications. It is our pleasure to invite you to contribute original research articles, communications, or review articles for consideration for the 2nd Edition of this Special Issue.

Dr. Christie Ying Kei Lung
Guest Editor

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Keywords

  • biomedical materials
  • tissue regeneration and repair
  • antimicrobial
  • drug delivery
  • material synthesis
  • material characterization
  • biocompatibility

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Published Papers (1 paper)

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Research

16 pages, 5120 KiB  
Article
A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells
by Jesús Alejandro Torres-Betancourt, Rene Hernández-Delgadillo, Juan Valerio Cauich-Rodríguez, Diego Adrián Oliva-Rico, Juan Manuel Solis-Soto, Claudia María García-Cuellar, Yesennia Sánchez-Pérez, Nayely Pineda-Aguilar, Samantha Flores-Treviño, Irene Meester, Sergio Eduardo Nakagoshi-Cepeda, Katiushka Arevalo-Niño, María Argelia Akemi Nakagoshi-Cepeda and Claudio Cabral-Romero
J. Funct. Biomater. 2024, 15(10), 309; https://doi.org/10.3390/jfb15100309 - 16 Oct 2024
Viewed by 889
Abstract
Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal [...] Read more.
Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal effects, were evaluated using a breast cancer cell line and methicillin-susceptible and resistant Staphylococcus aureus (MRSA). Drug-free Tecoflex™ EMs and Tecoflex™ EMs-BisBAL NPs had similar fiber diameters of 4.65 ± 1.42 µm and 3.95 ± 1.32 µm, respectively. Drug-free Tecoflex™ EMs did not negatively impact a human fibroblast culture, indicating that the vehicle is biocompatible. Tecoflex™ EMs-BisBAL NPs increased 94% more in size than drug-free Tecoflex™ EMs, indicating that the BisBAL NPs enhanced hydration capacity. Tecoflex™ EMs-BisBAL NPs were highly bactericidal against both methicillin-susceptible S. aureus and MRSA clinical isolates, inhibiting their growth by 93.11% and 61.70%, respectively. Additionally, Tecoflex™ EMs-BisBAL NPs decreased the viability of MCF-7 tumor cells by 86% after 24 h exposure and 70.1% within 15 min. Regarding the mechanism of action of Tecoflex™ EMs-BisBAL NPs, it appears to disrupt the tumor cell membrane. In conclusion, Tecoflex™ EMs-BisBAL NPs constitute an innovative low-cost drug delivery system for human breast cancer and postoperative wound infections. Full article
(This article belongs to the Special Issue Active Biomedical Materials and Their Applications, 2nd Edition)
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