Function, Regulation, and Dysfunction of Intrinsically Disordered Proteins, Volume II
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Proteins and Proteomics".
Deadline for manuscript submissions: closed (25 June 2021) | Viewed by 15919
Special Issue Editors
Interests: biochemistry; structural biology; functional intrinsically disordered proteins; parkinson; alzheimer
Special Issues, Collections and Topics in MDPI journals
Interests: protein folding; protein dynamics and disorder; protein-protein recognition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It has become acknowledged that a significant portion of proteins encoded in eukaryotic and prokaryotic genomes feature a partial or total degree of structural disorder. Disordered regions can regulate the biological activity of protein molecules, such as the propensity to generate molecular complexity, including the regulation of phase separations. The involvement of intrinsically disordered proteins in fundamental biological processes, including cellular signaling, protein translation, and transcriptional regulation, is increasingly reported to be crucial in functional and pathological mechanisms. The remarkable ability of these molecules to establish macromolecular interactions with multiple biomolecular partners is likely promoted by their inherent flexibility and ability to adapt their shape. While the functional role of IDPs is attracting an increasing research focus, understanding the underlying structural and mechanistic principles of their biological activity remains a crucial research challenge. The role of kinetic versus thermodynamic control is the key to understand the way by which these elusive systems are regulated to solve their intriguing biological functions.
Dr. Giuliana Fusco
Prof. Dr. Stefano Gianni
Guest Editors
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Keywords
- intrinsically disordered proteins
- post-translational modifications
- phase separation
- structural and functional dynamics
- binding promiscuity and fuzzy complexes
- molten globular states
- kinetic vs thermodynamic control
- conformational selection vs induced fit
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