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Life
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Oral Cancer—Diagnosis and Therapeutics 2020
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Oral Cancer—Diagnosis and Therapeutics 2020

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 8977

Special Issue Editors

Prof. Dr. Lorenzo Lo Muzio

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Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy
Interests: oral cancer, cancer stem cell, biomarkers, protein function; protein bioinformatics; protein–protein interactions; structure bioinformatics; cancer pharmaco-omics modelling; biomarker discovery; precision oncology; chemoinformatics; drug discovery informatics; virtual screening
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Eleonora Bizzoca

E-Mail
Co-Guest Editor
Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Foggia, Via Antonio Gramsci, 89, 71122 Foggia FG, Italy
Interests: oral cancer; cancer stem cell; head neck cancer; covid-19; biomarkers; protein–protein interactions; cancer pharmaco-omics modelling; biomarker discovery; precision oncology; virtual screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our 2018 Special Issue “Oral Cancer—Diagnosis and Therapeutics”.

Oral squamous cell carcinoma (OSCC) is the eight most common cancers worldwide, with an incidence that varies from 3–4% in North America and Europe, to 8–10% in Southwest Asia. Tobacco smoking, alcohol consumption and high-risk human papillomaviruses (HPV) infections are the most important risk factors for OSCC. Prognosis in OSCC is largely influenced by the stage at diagnosis. The most important prognostic factor is the involvement of lymph nodes, that decreases the survival rate by 50%. Furthermore, recurrences and distant metastases are associated with poor prognoses. Surgery is the standard treatment for OSCC, often followed by postoperative radiotherapy. Unfortunately, the survival rates have not significantly improved over the last decades, because of the high rate of recurrences and of advanced stages at presentation. The improved understanding of the mechanisms involved in cancer development may lead to the identification of new potential therapeutic targets, allowing the application of novel strategies to the clinical treatment of OSCC. The available conventional approaches in the treatment of advanced or recurrent/metastatic OSCC seems to have been reached a plateau during the past decades. Therefore, a wide spectrum of novel therapeutic agents is currently being tested in OSCC, with the aim to selectively target molecular signaling pathways or investigating immunotherapy and gene therapy strategies.

In this Special Issue, we invite front-line researchers and investigators to submit both original research and review articles regarding the following potential topics, but not limited to, focusing on the molecular aspects of cancer biology and medicine:

  • Surgical Therapy of oral cancer;
  • Radiation Therapy of oral cancer;
  • Chemotherapy of oral cancer;
  • Targeted therapy of oral cancer (i.e., Receptor tyrosine kynases antibodies, Tyrosine kinase inhibitors, Multi-kinase inhibition, others);
  • Immunotherapy of oral cancer;
  • Gene therapy of oral cancer;
  • Oral cancer Prognosis;
  • Natural substances in the therapy of oral cancer (ie. Plants derivates, others)
  • Novel approach and proof of principle in oral cancer therapy;
  • Related quality of life after oral cancer treatment; 

You may choose our Joint Special Issue in International Journal of Molecular Sciences.

Prof. Lorenzo Lo Muzio
Guest Editor
Dr. Maria Eleonora Bizzoca
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cancer
  • squamous cell carcinoma
  • surgery
  • radiation therapy
  • chemotherapy
  • immunotherapy
  • gene therapy
  • targeted therapy
  • quality of life

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Related Special Issue

Published Papers (3 papers)

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Research

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25 pages, 25235 KiB  
Article
Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma?
by Anna Starzyńska, Paulina Adamska, Aleksandra Sejda, Monika Sakowicz-Burkiewicz, Łukasz Jan Adamski, Giulia Marvaso, Piotr Wychowański and Barbara Alicja Jereczek-Fossa
Life 2020, 10(12), 325; https://doi.org/10.3390/life10120325 - 3 Dec 2020
Cited by 8 | Viewed by 2519
Abstract
Oral squamous cell carcinoma (OSCC) accounts for 95% of the lesions in the oral cavity. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new therapies in OSCC is urgently needed. One objective of such treatment may be a signaling [...] Read more.
Oral squamous cell carcinoma (OSCC) accounts for 95% of the lesions in the oral cavity. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new therapies in OSCC is urgently needed. One objective of such treatment may be a signaling pathway of phosphatidylinositol 3-kinase. The study group included 92 patients treated for OSCC at the University Clinical Centre in Gdańsk, Poland. Study was performed on formalin-fixed paraffin-embedded samples from primary OSCC. Phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) and phosphatase and tensin homolog encoded on chromosome 10 (PTEN) protein expression was assessed by immunohistochemistry (IHC). PIK3CA gene copy number was analyzed using chromogenic and silver in situ hybridization where molecular probes are marked by chromogens and silver ions. PIK3CA IHC H-score ≥ 70 was found in 51.65% patients, and loss of PTEN protein was noticed in 31.46% cases. PIK3CA amplification was detected in 5 tumors. In the case of PTEN protein expression, there was an inverse correlation with the T stage of the primary tumor (r = −0.243) and positive correlation with a 5-year survival (r = 0.235). The number of copies of the PIK3CA gene was associated with the tumor grading (r = 0.208). The present study shows that loss of PTEN protein and the grading (p = 0.040), distant metastases (p = 0.033), smoking (p = 0.016), and alcohol abuse (p = 0.042) were prognostic factors for the survival of patients with OSCC. In contrast, the presence of amplification and OSCC on the floor of the mouth resulted in a nearly six-fold increase in the risk of shortening survival (p = 0.037). Our finding suggests a potential prognostic significance of PTEN loss and PIK3CA amplification in OSCC. Future studies are needed to confirm our results. Full article
(This article belongs to the Special Issue Oral Cancer—Diagnosis and Therapeutics 2020)
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11 pages, 249 KiB  
Article
Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
by Stefania Leuci, Noemi Coppola, Andrea Blasi, Elvira Ruoppo, Maria Eleonora Bizzoca, Lorenzo Lo Muzio, Luana Marano, Antonio Maria Risitano and Michele Davide Mignogna
Life 2020, 10(10), 236; https://doi.org/10.3390/life10100236 - 9 Oct 2020
Cited by 9 | Viewed by 2130
Abstract
Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem-cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft-versus-host disease (cGVHD). The aim of this study was to describe a cohort of post-HSCT patients and to [...] Read more.
Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem-cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft-versus-host disease (cGVHD). The aim of this study was to describe a cohort of post-HSCT patients and to evaluate the onset of oral epithelial dysplasia and/or OSCC over time. In this retrospective cohort study, we present a cohort of hematological patients that underwent HSCT. Demographic variables, clinical hematological data, data regarding acute graft-versus-host disease (aGVHD) and cGVHD, and oral clinical features were analyzed. We focused on clinicopathological features of a subgroup of 22 patients with oral cGVHD and OSCC after HSCT. Among 80 included patients, 46 patients (57.5%) developed aGVHD and 39 patients (48.7%) developed cGVHD. Oral mucosa was involved in 17 patients with aGVHD (36.9%) and in 22 patients (56.4%) with cGVHD. Out of a total of 22 oral biopsies, roughly 40% revealed mild to moderate dysplasia, and 32% were OSCC. In the absence of international agreement on the best timing of oral follow-up after HSCT, it is mandatory to establish a close multidisciplinary evaluation in order to prevent the onset of HSCT-related OSCC and to reduce post-transplant mortality due to secondary tumors. Full article
(This article belongs to the Special Issue Oral Cancer—Diagnosis and Therapeutics 2020)

Review

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10 pages, 2266 KiB  
Review
From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
by Luca Calabrese, Maria Eleonora Bizzoca, Roberto Grigolato, Fausto Antonio Maffini, Marta Tagliabue, Rosa Negro, Stefania Leuci, Michele Davide Mignogna and Lorenzo Lo Muzio
Life 2020, 10(9), 197; https://doi.org/10.3390/life10090197 - 12 Sep 2020
Cited by 11 | Viewed by 3604
Abstract
Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis [...] Read more.
Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis in early stages, collective cell migration and circulating tumor cells in peripheral blood are some examples of the mechanisms that are currently receiving increasing attention in the evaluation of the prognosis of tongue cancers. Anatomic-based surgery showed that it is possible to improve loco-regional control of tongue cancer. In patients with a “T-N tract involvement”, there is significantly more distant recurrence (40%) in patients undergoing a compartmental tongue surgery. In general, the neoplastic infiltration of the lingual muscles is traced back to the finding of neoplastic tissue along the course of a muscle; however, the muscle fibers, due to their spatial conformation and the organization of the extracellular matrix, could influence the movement of tumor cells through the muscle, leaving its three-dimensional structure unchanged. We need to exclude the possibility that tongue muscle fibers represent a mechanism for the diffusion of cancer cells without muscle invasion. Full article
(This article belongs to the Special Issue Oral Cancer—Diagnosis and Therapeutics 2020)
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