Protein–Protein Interactions in Health and Disease
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 9513
Special Issue Editor
Interests: p53 family of proteins; p53 isoforms; metastatic melanoma; protein interactions; BRAF inhibitors; resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
All biological systems within a cell are controlled by proteins. While some proteins act on their own, the vast majority of proteins associate physically with each other, forming protein–protein interactions (PPIs), to regulate normal cellular functions and to undertake new biological functions.
In a critical step toward unravelling these complex protein functions, studies on molecular relationships and the biology of the cell have been mapping the physical “interactions” between proteins. Many PPIs take place in a cell in a particular biomolecular context. Furthermore, PPIs are specific and can be both transient and stable. While stable interactions are necessary for protein complexes such as the hemoglobin ribosome, dynamic, brief interactions that modify the specific protein functions are transient and may lead to further alterations.
Therefore, an understanding of the physical contact between proteins in a cell is crucial for understanding cell physiology in normal and disease conditions. Many diseases, including cancer, are the result of the disruption of regular PPIs as well as aberrant PPIs, including endogenous cellular proteins and proteins from pathogens. Therefore, the reconstruction of regular or inhibition of aberrant interactions has significant clinical importance. PPIs can be affected by small molecules, some of which are already approved for clinical applications, therefore studying the nature of the PPIs is important for drug development.
Protein–protein interactions have been increasingly studied using several approaches, and the obtained information enables the establishment of large protein interaction networks. The PPIs contribute to the interactome, the collection of molecular interactions that occur either in a cell, in an organism or in a specific biological context. Due to the development of large-scale, high-throughput screening techniques, we are able to obtain an immense quantity of data which are available in databases and could have therapeutic importance.
Dr. Neda Slade
Guest Editor
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Keywords
- protein–protein interactions
- protein complex
- protein–protein interactions inhibitors
- protein networks
- interactome
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