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Magnetochemistry
Special Issues
Advances in Magnetic Nanocarrier for Biomedical Applications
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Advances in Magnetic Nanocarrier for Biomedical Applications

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Applications of Magnetism and Magnetic Materials".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 6749

Special Issue Editor

Dr. Samson Olatubosun Aisida

E-Mail Website
Guest Editor
Department of Physics, University of Nigeria, Nsukka, Nigeria
Interests: ferrite materials; metallic materials; superparamagnetic; magnetic hyperthermia; magnetic drug delivery; nanomaterials

Special Issue Information

Dear Colleagues,

Magnetic nanocarrier such as superparamagnetic iron oxide nanoparticles (SPION) is one of the emerging topics in nanomaterials that has attracted great attention in biomedical applications. This applications span through targeted drug delivery (TDD), magnetic hyperthermia (MH) and magnetic resonance imaging (MRI). This applications is due to the wide range of advantages which includes, reasonable particle size, high surface-volume ratio. The topic of this issue covers new area and advances in metallic and bimettalic magnetic materials to the applications in TDD, MH and MRI. Recent applications of magnetic materials for nanotherapy compared to other therapies. This Special Issue reviews the current status and future perspectives of magnetic materials.

Dr. Samson Olatubosun Aisida
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

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Published Papers (3 papers)

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Research

22 pages, 6973 KiB  
Article
Investigation of Cubic and Spherical IONPs’ Rheological Characteristics and Aggregation Patterns from the Perspective of Magnetic Targeting
by Maria-Cristina Ioncica, Sulalit Bandyopadhyay, Nesrine Bali, Vlad Socoliuc and Sandor I. Bernad
Magnetochemistry 2023, 9(4), 99; https://doi.org/10.3390/magnetochemistry9040099 - 2 Apr 2023
Cited by 4 | Viewed by 2454
Abstract
Based on our prior research, we synthesized iron-oxide nanoparticles (IONPs) in two shapes (spherical and cubic) and sized them for the current inquiry. This research examined the magnetic, rheological, and sedimentation properties of the suspensions containing PEG-coated IONPs, considering that both produced particles [...] Read more.
Based on our prior research, we synthesized iron-oxide nanoparticles (IONPs) in two shapes (spherical and cubic) and sized them for the current inquiry. This research examined the magnetic, rheological, and sedimentation properties of the suspensions containing PEG-coated IONPs, considering that both produced particles are intended to be employed for magnetic targeting applications. The saturation magnetization of both IONPs was lower than the magnetite domain magnetization of 92 emu/g due to the surfactant and the dead surface magnetic layer. Under each investigated magnetic field (0, 34 and 183 mT), the shear viscosity behaviour of the MNP suspensions of both kinds was comparable. Shear thinning behaviour was seen for both particle suspensions in the low shear rate area (0.1 s−1 to 1 s−1). The rheological curves from this paper show that the suspensions present a higher viscosity at lower shear rates for spherical and cubic PEG-coated nanoparticles when a magnetic field is applied. The aggregation behaviour demonstrates that cubic-shaped IONPs are more stable throughout time, with hydrodynamic diameter measurements showing a relatively slow variation of the DLS size distribution from 250 nm to 210 nm in the first 600 s; contrarily, the hydrodynamic diameter of spherical IONPs fluctuated significantly, from 855 nm to 460 nm. Another key finding relates to the sedimentation profile, specifically that PEG-coated IONPs with spherical shapes have a stronger tendency to sediment than those with cubic forms, which are more stable. Full article
(This article belongs to the Special Issue Advances in Magnetic Nanocarrier for Biomedical Applications)
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13 pages, 2975 KiB  
Article
Delivery of dCas9 Activator System Using Magnetic Nanoparticles Technology as a Vector Delivery Method for Human Skin Fibroblast
by Mahdi Mohammadi Ghanbarlou, Shahriyar Abdoli, Hamed Omid, Leila Qazizadeh, Hadi Bamehr, Mozhgan Raigani, Hosein Shahsavarani, Morteza Karimipour and Mohammad Ali Shokrgozar
Magnetochemistry 2023, 9(3), 71; https://doi.org/10.3390/magnetochemistry9030071 - 28 Feb 2023
Cited by 5 | Viewed by 1995
Abstract
The overexpression of stem cell-related genes such as octamer-binding transcription factor 4 (OCT4) and (sex determining region Y)-box 2 (SOX2) has been indicated to play several critical roles in stem cell self-renewal; moreover, the elevation of the self-renewal of cancer cells with stem [...] Read more.
The overexpression of stem cell-related genes such as octamer-binding transcription factor 4 (OCT4) and (sex determining region Y)-box 2 (SOX2) has been indicated to play several critical roles in stem cell self-renewal; moreover, the elevation of the self-renewal of cancer cells with stem cell-like properties has been suggested. The clustered and regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) protein fused to transactivation domains can be used to activate gene expression in human cells. CRISPR-mediated activation (CRISPRa) systems represent an effective genome editing tool for highly specific gene activation in which a nuclease-deficient Cas9 (dCas9) is utilized to target a transcriptional activator to the gene’s regulatory element, such as a promoter and enhancer. The main drawback of typical delivery methods for CRISPR/Cas9 components is their low transfection efficiency or toxic effects on cells; thus, we generated superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) to improve the delivery of CRISPR/Cas9 constructs into human foreskin fibroblast cells. The delivery system with magnetic PEI-coated nanoparticles complex was applied to constitute plasmid DNA lipoplexes. CRISPRa systems were used to overexpress the endogenous OCT4 and SOX2 in fibroblast cells. The quantitative polymerase chain reaction (QPCR) assessment exhibited a three-times higher expression of OCT4 and SOX2 transfected by CRISPRa using MNPs. Moreover, no additional cytotoxicity was observed with the application of magnetic nanoparticles (MNPs) compared to lipofectamine. Our results demonstrate that MNPs enable the effective delivery of the CRISPR/Cas9 construct into human foreskin fibroblasts with low cell toxicity and a consequential overexpression of endogenous OCT4 and SOX2. Full article
(This article belongs to the Special Issue Advances in Magnetic Nanocarrier for Biomedical Applications)
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10 pages, 3662 KiB  
Article
Superparamagnetic-like Micrometric Single Crystalline Magnetite for Biomedical Application Synthesis and Characterization
by Marius Chirita, Adrian Bezergheanu, Corneliu Bazil Cizmas and Aurel Ercuta
Magnetochemistry 2023, 9(1), 5; https://doi.org/10.3390/magnetochemistry9010005 - 24 Dec 2022
Cited by 1 | Viewed by 1742
Abstract
Single-crystalline magnetite (Fe3O4) particles having a size beyond the nanometric range (1 µm to 50 µm) and showing high (close to the bulk value) saturation-specific magnetization (σs = 92 emu/g), were obtained by the hydrothermal decomposition of the [...] Read more.
Single-crystalline magnetite (Fe3O4) particles having a size beyond the nanometric range (1 µm to 50 µm) and showing high (close to the bulk value) saturation-specific magnetization (σs = 92 emu/g), were obtained by the hydrothermal decomposition of the Fe-EDTA complex. The very low values of the magnetic remanence (σr = 0.82 emu/g) and coercitivity (μoHc = 1.53 mT) observed at room temperature (RT) suggest a superparamagnetic-like behavior, which is quite remarkable for such micrometric magnetite particles. As confirmed by vibrating sample magnetometer (VSM)-based measurements, minor changes in their magnetic properties occur between RT and 5K. Scanning electron microscopy (SEM) has revealed a morphology consisting of a combination of non-porous octahedral- and dodecahedral-shaped particles, energy dispersive X-ray analysis (EDX) has indicated high elemental (Fe and O) purity, whereas X-ray diffraction (XRD) has confirmed a single crystal structure. The nitrogen adsorbtion–desorption isotherm and pore size distribution are presented for the magnetite sample. Thermomagnetic records under zero field-cooled (ZFC) and field-cooled (FC) conditions have revealed a thermal hysteresis of the Verwey transition.The Verwey point (TV) at which the major step of the phase transformation takes place is located around 132 K for heating and around 122 K for cooling. These microcrystals do not remain agglomerated when the polarizing field is removed, an essential requirement in biomedical applications is met. Full article
(This article belongs to the Special Issue Advances in Magnetic Nanocarrier for Biomedical Applications)
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