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Metabolites
Special Issues
New Insights into Gut Microbiota and Obesity
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New Insights into Gut Microbiota and Obesity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (25 May 2024) | Viewed by 4481

Special Issue Editor

Dr. Natalia G. Vallianou

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Guest Editor
First Department of Internal Medicine, Sismanogleio General Hospital, Athens, Greece
Interests: infectious diseases; diabetes; obesity; microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The role of the gut microbiota in health seems to be important and multifaceted. The human gut microbiota begins in utero and continues to be shaped throughout life under the influence of various factors, such as diet, drugs administration and the aging process. On the other hand, obesity and obesity-related disorders pose a major public health issue world widely.

In this Special Issue, we will focus upon the interplay of diet, nutritional aspects and various metabolic biomarkers, which are produced by the gut microbiota in response to dietary factors. The scope of this Issue will be to emphasize the importance of healthier diets with regard to the gut microbiome as a venue to combat obesity and obesity-related disorders. The purpose will be to point out the significance and beneficial efficacy of probiotics, prebiotics, synbiotics and postbiotics as well as the potential of next-generation probiotics in this context. The therapeutic potential of next-generation probiotics as well as the pros and cons of these promising agents will be further discussed. In addition, the difficulties in research for possible next-generation probiotics together with the diagnostic difficulties regarding the composition of the gut microbiota in the multi-omics era will be elucidated in this Special Issue

Dr. Natalia G. Vallianou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • obesity
  • diet
  • metabolomics
  • probiotics
  • prebiotics

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Published Papers (2 papers)

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Research

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17 pages, 2212 KiB  
Article
Intestinal Dysbiosis in Subjects with Obesity from Western Mexico and Its Association with a Proinflammatory Profile and Disturbances of Folate (B9) and Carbohydrate Metabolism
by Verónica Riggen-Bueno, Susana Del Toro-Arreola, Tonatiuh Abimael Baltazar-Díaz, Alejandra N. Vega-Magaña, Marcela Peña-Rodríguez, Paula Alejandra Castaño-Jiménez, Laura Verónica Sánchez-Orozco, José María Vera-Cruz and Miriam Ruth Bueno-Topete
Metabolites 2024, 14(2), 121; https://doi.org/10.3390/metabo14020121 - 11 Feb 2024
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Abstract
Obesity is a public health problem with a growing prevalence worldwide. In Mexico, it is estimated that one out of three adults suffer from obesity. In these patients, the intestinal microbiota (IM) undergoes pathological changes that are associated with a dysbiotic state; however, [...] Read more.
Obesity is a public health problem with a growing prevalence worldwide. In Mexico, it is estimated that one out of three adults suffer from obesity. In these patients, the intestinal microbiota (IM) undergoes pathological changes that are associated with a dysbiotic state; however, the microbiota profile of adult subjects with obesity from western Mexico has not been described. To assess this, fecal samples were obtained from 65 participants (Obese = 38; Control = 27). The microbial composition was characterized by 16S rRNA amplicon sequencing. The IM of the group with obesity revealed a clear decrease in richness and diversity (p < 0.001), as well as a significant increase in proinflammatory bacterial groups, mainly genera belonging to the Negativicutes class, Escherichia/Shigella, and Prevotella. Likewise, an increase in short-chain fatty acid-producing bacteria was found, especially the genus Lachnoclostridium. Additionally, PICRUSt2 analysis showed a depletion of vitamin B9 metabolism and an increase in saccharolytic pathways. The IM of patients with obesity possesses a dysbiotic, proinflammatory environment, possibly contributing to lipogenesis and adiposity. Thus, assessing the IM will allow for a better understanding of the pathophysiology of metabolic diseases of high prevalence, such as obesity. These findings are described for the first time in the adult population of western Mexico. Full article
(This article belongs to the Special Issue New Insights into Gut Microbiota and Obesity)
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Review

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21 pages, 2117 KiB  
Review
NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options
by Natalia G. Vallianou, Dimitris Kounatidis, Sotiria Psallida, Nikolaos Vythoulkas-Biotis, Andreas Adamou, Tatiana Zachariadou, Sofia Kargioti, Irene Karampela and Maria Dalamaga
Metabolites 2024, 14(7), 366; https://doi.org/10.3390/metabo14070366 - 28 Jun 2024
Cited by 6 | Viewed by 1955
Abstract
Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. Nonalcoholic steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in the western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic liver disease (MASLD). [...] Read more.
Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. Nonalcoholic steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in the western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic liver disease (MASLD). The introduction of this new terminology has sparked a debate about the interchangeability of these terms. The pathogenesis of NAFLD/MASLD is thought to be multifactorial, involving both genetic and environmental factors. Among these factors, alterations in gut microbiota and gut dysbiosis have recently garnered significant attention. In this context, this review will further discuss the gut–liver axis, which refers to the bidirectional interaction between the human gut microbiota and the liver. Additionally, the therapeutic potential of probiotics, particularly next-generation probiotics and genetically engineered bacteria, will be explored. Moreover, the role of prebiotics, synbiotics, postbiotics, and phages as well as fecal microbiota transplantation will be analyzed. Particularly for lean patients with NAFLD/MASLD, who have limited treatment options, approaches that modify the diversity and composition of the gut microbiota may hold promise. However, due to ongoing safety concerns with approaches that modulate gut microbiota, further large-scale studies are necessary to better assess their efficacy and safety in treating NAFLD/MASLD. Full article
(This article belongs to the Special Issue New Insights into Gut Microbiota and Obesity)
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