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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Metabolites from Plants

edited by

Luis Francisco Salomé-Abarca

and

Dejan Godjevac

submission deadline 25 Aug 2025 | Viewed by 142 | Submission Open

Keywords: metabolites; bioactivity; identification; quantification; metabolomics; nutraceuticals; antibiosis; antixenosis; medicinal

(This special issue belongs to the Section Plant Metabolism)

Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

edited by

Sergio Ortiz

submission deadline 25 Aug 2025 | Viewed by 133 | Submission Open

Keywords: extraction; metabolomics; phytochemical dereplication; isolation of plant metabolites; biological evaluation

(This special issue belongs to the Section Plant Metabolism)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment

edited by

Susumu Muroya

submission deadline 30 Aug 2025 | 4 articles | Viewed by 8082 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Targeting Microbiota and Metabolites for Prevention and Treatment of Human Diseases

edited by

Zhipeng Tao

and

Danhui Wang

submission deadline 31 Aug 2025 | 4 articles | Viewed by 7106 | Submission Open

Keywords: microbiota; metabolites; metabolic diseases; cancer; cardiovascular diseases; liver diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management

edited by

Davide Masi

and

Renata Risi

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5995 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Emerging Applications of Metabolomics in Fermented Food

edited by

Eiichiro Fukusaki

, Akira Oikawa,

Yasuyo Sekiyama

and Kazuhiro Iwashita

submission deadline 31 Aug 2025 | 3 articles | Viewed by 5866 | Submission Open

Keywords: food metabolomics; fermented food; fermentation; fermentation microorganisms; flavor; food secondary function; sensory evaluation; health-promoting function; food ternary function; nutrition

(This special issue belongs to the Section Food Metabolomics)

Brain Metabolic Alterations in Neurodegenerative Diseases

edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4998 | Submission Open

Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Nutrition and Metabolism)

Drug Metabolism and New Drug Development for Cancers

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4696 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

edited by

Boqun Liu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4050 | Submission Open

Keywords: peptide; absorption; metabolism; structure– function relationships; metabolic pathways

(This special issue belongs to the Section Nutrition and Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3743 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1727 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 31 Aug 2025 | Viewed by 338 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

Hyperlipidemia Related Endocrine Disease and Cancer in Human and Animal

edited by

Kyuhyung Choi

submission deadline 31 Aug 2025 | Viewed by 131 | Submission Open

Keywords: hyperlipidemia; diabetes mellitus; Cushing’ s disease; pancreatitis; hepatocellular carcinoma; mammary gland tumor; colorectal cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 31 Aug 2025 | Viewed by 115 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 31 Aug 2025 | Viewed by 88 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Insulin Clearance and Metabolic Dysregulation in Health and Disease

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 31 Aug 2025 | Viewed by 88 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Food Science and Nutrition Using GC-MS

edited by

Ryota Mabuchi

Genya Okada

and

Yonghuan Yun

submission deadline 31 Aug 2025 | Viewed by 17 | Submission Open

Keywords: GC-MS; metabolome analysis; metabolic profiling; foodomics; nutritional metabolomics; dietary bi-omarkers; food quality; primary metabolites; lipidomics; odor and/or aroma components

(This special issue belongs to the Section Food Metabolomics)

Amino Acid Metabolism in Angiogenesis

edited by Roxana Elena Oberkersch and

Teodoro Bottiglieri

submission deadline 31 Aug 2025 | Viewed by 7 | Submission Open

Keywords: amino acid metabolism; endothelial cells; angiogenesis; metabolic pathways; cellular crosstalk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition Intake on Pet Metabolism

edited by

Giulia Pignataro

submission deadline 1 Sep 2025 | Viewed by 92 | Submission Open

Keywords: pet nutrition; pet food; nutraceuticals; clinical dietetics; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 15 Sep 2025 | Viewed by 51 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 15 Sep 2025 | Viewed by 45 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

Metabolomics in Chronic Disease

edited by Xiaoyu Che

submission deadline 20 Sep 2025 | Viewed by 354 | Submission Open

Keywords: metabolomics; chronic diseases; multi-omics; bioinformatics; biomarker discovery; system biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects

edited by

Woojin Kim

submission deadline 20 Sep 2025 | Viewed by 293 | Submission Open

Keywords: chemotherapy-induced side effects; pain; nausea and vomiting; neutropenia

(This special issue belongs to the Section Plant Metabolism)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 20 Sep 2025 | Viewed by 144 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Multi-Omics Dissection of EMT-Driven Cancer Metabolism in Drug Resistance and Metastasis

edited by Lei Huang

submission deadline 20 Sep 2025 | Viewed by 17 | Submission Open

Keywords: multi-omics; EMT; drug-resistant; metastasis; metabolism-driven therapies

(This special issue belongs to the Section Cell Metabolism)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Sep 2025 | 6 articles | Viewed by 8785 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Insights into Metabolism, Diagnostics and Therapeutics of Cancer and Tumor Microenvironment by NMR Spectroscopy

edited by

Shivanand M. Pudakalakatti

and

Pratip K. Bhattacharya

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4224 | Submission Open

Keywords: cancer metabolism; early diagnosis; therapeutic intervention; NMR spectroscopy; instrument development; pulse sequence design; metabolites; software for metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Advances in Metabolomics and Multi-Omics Integration

edited by

Kurt K. Zhang

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3410 | Submission Open

Keywords: metabolomics; cellular metabolism; multi-omics; metabolites; molecular interaction; cell– cell cross-talk

(This special issue belongs to the Section Integrative Metabolomics)

Unlocking Nature's Toolbox: Advances in Plant Metabolites Identification

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Sep 2025 | 4 articles | Viewed by 3230 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2195 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Lipidomic Signatures in Pediatric Metabolic Disorders

edited by

Mónica Narváez-Rivas

submission deadline 30 Sep 2025 | Viewed by 387 | Submission Open

Keywords: lipidomics; lipids; mass spectrometry; pediatric population; therapeutic targets; biomarkers; metabolic disorder

(This special issue belongs to the Section Lipid Metabolism)

Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine

edited by

Katarzyna Jakimiuk

and Arkadiusz Surażyński

submission deadline 30 Sep 2025 | Viewed by 233 | Submission Open

Keywords: natural plant products; biological and pharmacological activity; isolation; disease prevention and treatment; natural plant drug discovery

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Sep 2025 | Viewed by 151 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Circadian System Associated with Lipid Metabolism and Metabolic Diseases

edited by

Xiaoyue Pan

submission deadline 30 Sep 2025 | Viewed by 95 | Submission Open

Keywords: circadian rhythm; circadian clock; lipid transport; lipid oxidation; lipid synthesis; lipid metabolism; lipoprotein

(This special issue belongs to the Section Cell Metabolism)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Oct 2025 | Viewed by 274 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Nov 2025 | Viewed by 346 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome

edited by Lapo Renai and

Massimo Del Bubba

submission deadline 16 Nov 2025 | Viewed by 85 | Submission Open

Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification

(This special issue belongs to the Section Environmental Metabolomics)

Neurometabolics in a Nutshell

edited by

Justyna Paprocka

submission deadline 20 Nov 2025 | Viewed by 50 | Submission Open

Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options

(This special issue belongs to the Section Cell Metabolism)

Metabolomics and Plant Defence, 2nd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 5 Dec 2025 | Viewed by 100 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Lipid Signaling, Therapeutics and Controlled-Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1307 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 31 Dec 2025 | Viewed by 219 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolites in Animal Nutrition and Physiological Regulations Under Stress Conditions

edited by

Hieu Huu Le

and

Majid Shakeri

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: metabolic; nutrition; amino acids; meat quality; metabolites; fatty acids; non-esterified fatty acids (NEFA); physiology; metabolism; dietary supplementation

(This special issue belongs to the Section Animal Metabolism)

Selected Papers from the 4th International Electronic Conference on Metabolomics

edited by