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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 30 Jun 2025 | Viewed by 517 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity

edited by

Pengcheng Wang

submission deadline 30 Jun 2025 | Viewed by 465 | Submission Open

Keywords: metabolomics; drug/xenobiotic metabolism; drug– drug interactions; drug toxicity; ADME; new modalities peptides; antibody-drug conjugates; protein therapeutics; oligonucleotide therapeutics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 30 Jun 2025 | Viewed by 442 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Effects of Diet on Metabolic Health of Obese People

edited by

Magdalena Górnicka

Marta Jeruszka-Bielak

and Irena Keser

submission deadline 30 Jun 2025 | Viewed by 406 | Submission Open

Keywords: diet; dietary pattern; bioactive food compounds; body composition; nutrition-related biomarkers; metabolites; metabolic disorders; obesity

(This special issue belongs to the Section Nutrition and Metabolism)

Effects of Exercise on Cardiooncology and Cancer Metabolism

edited by Darpan I. Patel

submission deadline 30 Jun 2025 | Viewed by 313 | Submission Open

Keywords: exercise; physical activity; yoga; tai chi; metabolism; cardiooncology; cardiotoxicities; obesity; metabolism syndrome; metabolomics; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Understanding Metabolic-Associated Fatty Liver Disease: Insights into Mechanisms and Management

edited by Jingda Li and Wenlong Sun

submission deadline 30 Jun 2025 | Viewed by 221 | Submission Open

Keywords: oxidative stress; mitochondrial dysfunction; endoplasmic reticulum stress; inflammation; apoptosis; pyroptosis; gut microbiota disorder; metabolites

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Vitamin D Metabolism and Human Health

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 30 Jun 2025 | Viewed by 212 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D receptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

The Impact of Polyphenols on Metabolic Health and Disease

edited by

Si Qin

and Kozue Sakao

submission deadline 30 Jun 2025 | Viewed by 208 | Submission Open

Keywords: polyphenols; metabolic diseases; molecular mechanisms; intervention; AI

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 30 Jun 2025 | Viewed by 153 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends

edited by

Mohammad Mehdi Banoei

and

Mehdi Mirsaeidi

submission deadline 30 Jun 2025 | Viewed by 144 | Submission Open

Keywords: mass spectrometry-based metabolomics; targeted metabolomics; health and disease; precision medi-cine; biomarker discovery; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Regulation of Metabolic Pathways in Ruminant Animal Cells and Physiology

edited by Guanghua Su

submission deadline 30 Jun 2025 | Viewed by 98 | Submission Open

Keywords: ruminants; cell metabolism; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Food Intake and Bioactive Metabolism in Human

edited by Anallely López-Yerena and Emily P. Laveriano Santos

submission deadline 30 Jun 2025 | Viewed by 72 | Submission Open

Keywords: bioactive compounds; phytochemical; carotenoids; polyphenols; oxylipins; gut microbiota; bioavailability; personalized nutrition; functional foods; disease prevention

(This special issue belongs to the Section Nutrition and Metabolism)

Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

edited by Mark G. Filipovic, Corina Manuela Bello and Markus M. Luedi

submission deadline 30 Jun 2025 | Viewed by 43 | Submission Open

Keywords: cardiovascular; biomarkers; risk factors; outcome; prognostication; metabolism; metabolomics; risk markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications

edited by Adam D. Kennedy and Greg Michelotti

submission deadline 1 Jul 2025 | Viewed by 199 | Submission Open

Keywords: metabolomics; precision medicine; clinical disease; biomarkers; therapeutics; clinical metabolomics; nutrition; functional medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional Intervention and Metabolic Health: Multi-Omics Insights

edited by Qingqing Mao,

Yuyin Zhou

and

Hongming Su

submission deadline 1 Jul 2025 | Viewed by 135 | Submission Open

Keywords: nutrition metabolism; metabolomics; metabolic diseases; lipidomics; proteomics; diet and nutrition; nutritional intervention; diet pattern

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

edited by

Samuel Treviño

submission deadline 1 Jul 2025 | Viewed by 79 | Submission Open

Keywords: murine models; metabolic diseases; molecular mechanisms; biochemical pathways; pharmacological strategies; interactome; comorbidities; metabolic phenotypes; novel techniques

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism Disorders in Obesity

edited by

Klaudia Sztolsztener

and

Elzbieta Supruniuk

submission deadline 10 Jul 2025 | Viewed by 240 | Submission Open

Keywords: fatty liver diseases; overweight and obesity; cardiometabolic risks; lipid metabolism; metabolic syndrome; adipose tissue

(This special issue belongs to the Section Lipid Metabolism)

Climate Change-Related Stresses and Plant Metabolism

edited by

Eva Collakova

submission deadline 14 Jul 2025 | Viewed by 95 | Submission Open

Keywords: plant physiology and metabolism; climate change-related stresses; multi-omics approaches; plant stress phenotyping; crop improvement

(This special issue belongs to the Section Plant Metabolism)

Drug Metabolism: Latest Advances and Prospects

edited by

Michel Kranendonk

and Bernardo Brito Palma

submission deadline 15 Jul 2025 | 2 articles | Viewed by 2694 | Submission Open

Keywords: xenobiotic metabolism; drug-metabolizing enzymes; pharmacokinetics/toxicokinetics; pharmacody-namics/toxicodinamics; biotransformation; metabolomics; drug clearance; polymophisms; metabolic profiling; personalized medicine; adverse drug reactions (ADRs); drug-induced liver injury (DILI)

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Lipid Biomarkers and Cardiometabolic Diseases—2nd Edition

edited by

Hyun Suk Yang

submission deadline 15 Jul 2025 | 1 articles | Viewed by 809 | Submission Open

Keywords: lipid profiles; lipid metabolism; cholesterol; dietary fat; cardiovascular diseases; metabolic diseases

(This special issue belongs to the Section Lipid Metabolism)

Psoriasis and Metabolic Syndrome

edited by Anna Baran

submission deadline 15 Jul 2025 | Viewed by 170 | Submission Open

Keywords: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids

(This special issue belongs to the Section Lipid Metabolism)

Gut Microbiome and Host Metabolism

edited by Weilan Wang, Nuanyi Liang and

Chunlong Mu

submission deadline 15 Jul 2025 | Viewed by 138 | Submission Open

Keywords: host– microbiome interactions; metabolic diseases; carbohydrate metabolism; amino acids metabo-lism; lipids metabolism; metagenomics; (meta)transcriptomics; metabolomics; multi-omics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

New Trends in Drug Pharmacokinetics and Metabolism Research

edited by

Rongjin Sun

and Steven C. Laizure

submission deadline 20 Jul 2025 | Viewed by 12 | Submission Open

Keywords: local bioavailable drug; drug– herb interactions; machine learning; advanced modeling techniques; gut microbiome; in vitro to in vivo extrapolation; monoclonal antibodies; peptides; oligonucleotides

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Diet, Gut Microbiota and Metabolic Health

edited by

Hui Han

and

Jing Wang

submission deadline 21 Jul 2025 | Viewed by 93 | Submission Open

Keywords: diet; nutrition; gut microbiota; metabolites; metabolism

(This special issue belongs to the Section Animal Metabolism)

Energy Metabolism in Neurodegenerative Diseases

edited by

Marta Tomczyk

and

Magdalena Podlacha

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2570 | Submission Open

Keywords: energy metabolism; neurodegeneration; neurodegenerative disease; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; spinal muscular atrophy; Lewy body disease; multiple sclerosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases

edited by

Marcelo Macedo Rogero

and

Marco Antonio Hernández-Lepe

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1609 | Submission Open

Keywords: metabolism; diseases; bioactive compounds; food; metabolites

(This special issue belongs to the Section Nutrition and Metabolism)

Obesity and Metabolic Health

edited by

Natalia Ferreira Mendes

and

Eliana Pereira De Araújo

submission deadline 30 Jul 2025 | 2 articles | Viewed by 1591 | Submission Open

Keywords: glial cells; blood– brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy me-tabolism; food intake; brown adipose tissue; leptin; insulin resistance; bioactive compounds; epige-netics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advancements in Reproductive Medicine: Unlocking the Secrets of the Ovary and Sperm for Fertility and Beyond

edited by

Konstantinos Dafopoulos

and

Efthalia Moustakli

submission deadline 30 Jul 2025 | Viewed by 162 | Submission Open

Keywords: oocytes; sperm; fertility; biomarkers; omics; metabolism; PCOS; oxidative stress; reproductive aging; metabolic interventions; assisted reproductive technologies (ART)

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Metabolites from Natural Sources (2nd Edition)

edited by

Miroslava Zhiponova

and Zhenya P. Yordanova

submission deadline 31 Jul 2025 | 3 articles | Viewed by 8156 | Submission Open

Keywords: primary metabolites; secondary metabolites; nature-based synthetic molecules; molecular mechanisms; models; evolution; food; agriculture; health; in vitro biological activities; in vivo biological activities

(This special issue belongs to the Section Plant Metabolism)

Integration of Emerging Technologies in Metabolite Analysis

edited by Kumari Ubhayasekera

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1482 | Submission Open

Keywords: liquid chromatography; mass spectrometry; NMR; metabolomics; smaller molecules; supercritical chromatography; gas chromatography

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1056 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

Cell Death and Cancer Metabolism

edited by

Zhengrong Yuan

submission deadline 31 Jul 2025 | Viewed by 321 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor growth; metabolic biomarkers; therapeutic strategies; metabolic regulation; cancer treatment

(This special issue belongs to the Section Cell Metabolism)

Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

edited by

Dechun Chen

submission deadline 31 Jul 2025 | Viewed by 238 | Submission Open

Keywords: metabolomics; environmental contaminants; biomarkers; toxicity mechanisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Programming of Hepatic Organ Function—2nd Edition

edited by

Philipp Kasper

submission deadline 31 Jul 2025 | Viewed by 213 | Submission Open

Keywords: metabolism; liver; early life environment; developmental programming; epigenetics; metabolic syndrome; obesity; metabolic-dysfunction-associated fatty liver disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Impact of Environmental Contaminants on Neurodevelopment and Human Metabolism

edited by

Cláudia Sirlene Oliveira

and Izonete Cristina Guiloski

submission deadline 31 Jul 2025 | Viewed by 203 | Submission Open

Keywords: pesticides; metals; mercury; methylmercury; developing organism; oxidative stress

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention

edited by Songhua Hu, Yahui Wang and

Daniel Oscar Cicero

submission deadline 31 Jul 2025 | Viewed by 198 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; metabolic plasticity; cancer heterogeneity; therapeutic resistance; tumor microenvironment; combination therapies

(This special issue belongs to the Section Cell Metabolism)

Machine Learning Applications in Metabolomics Analysis: 2nd Edition

edited by

Leonardo Franco

and

Martin Grootveld

submission deadline 31 Jul 2025 | Viewed by 192 | Submission Open

Keywords: metabolites; biofluids; artificial intelligence; metabolomics; machine learning

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Microalgae Bioactive Compounds with Therapeutical Properties

edited by Miguel Martín-Pérez and

Sergio Balzano

submission deadline 31 Jul 2025 | Viewed by 189 | Submission Open

Keywords: microalgae; bioactive compounds; therapeutical properties; cancer; neurodegenerative diseases

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Primary Hyperparathyroidism: Mechanisms and Treatment

edited by Elena Castellano and

Federica Saponaro

submission deadline 31 Jul 2025 | Viewed by 78 | Submission Open

Keywords: primary pyperparathyroidism; mechanism; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism in Kidney Disease

edited by

Vincenzo Calabrese

Elisa Longhitano

and

Domenico Santoro

submission deadline 31 Jul 2025 | Viewed by 77 | Submission Open

Keywords: biomarkers; CKD; dialysis; electrolytes; metabolism; inflammation; survey

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 31 Jul 2025 | Viewed by 50 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Toxicometabolomics for Metabotyping and Novel Mechanisms

edited by

Chi Chen

submission deadline 31 Jul 2025 | Viewed by 41 | Submission Open

Keywords: toxicometabolomics; metabolite markers; xenobiotic metabolism; endogenous metabolism; microbial metabolism; metabolic activation; metabolic detoxification

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Syndrome in Polycystic Ovary Syndrome

edited by Sebastiao Freitas De Medeiros and

Alice S. Ryan

submission deadline 31 Jul 2025 | Viewed by 35 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; hyperandrogenism; hyperinsulinemia; hypertension; metabolic syndrome; polycystic ovary syndrome; visceral obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

NMR-Based Metabolomics in Biomedicine and Food Science

edited by

Gaia Meoni

and

Alessia Vignoli

submission deadline 11 Aug 2025 | Viewed by 84 | Submission Open

Keywords: metabolomics; NMR; biomedicine; food; fingerprinting; profiling; AI; ML

(This special issue belongs to the Section Metabolomic Profiling Technology)

Investigation of the Metabolic Mechanisms Underlying Breast Cancer: Navigating from Diagnosis to Survivorship

edited by Hongjin Li

submission deadline 15 Aug 2025 | 2 articles | Viewed by 2112 | Submission Open

Keywords: breast cancer; metabolomics; biomarker; diagnosis; tumor; survivorship; treatment; data analysis

(This special issue belongs to the Section Advances in Metabolomics)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 15 Aug 2025 | 2 articles | Viewed by 1657 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional dis-orders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Biostatistics and Bioinformatics in Metabolomics Research: From Study Design and Analytics to Clinical Insights and Public Health Implications

edited by Marinella Temprosa

submission deadline 15 Aug 2025 | Viewed by 165 | Submission Open

Keywords: biostatistics; bioinformatics; metabolomics; data preprocessing in metabolomics; feature selection in high-dimensional data; statistical pathway analysis; multi-omics integration; predictive modeling

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Effects of Nutrition and Exercise on Cardiometabolic Health

edited by

Sam Emerson

submission deadline 18 Aug 2025 | Viewed by 113 | Submission Open

Keywords: cardiovascular health; metabolic health; diet; nutrition; exercise; physical activity; body composition; obesity; metabolites; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Stress on Animal Metabolism

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 18 Aug 2025 | Viewed by 46 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

Machine Learning in Metabolomics: Unlocking the Future of Data Analysis

edited by

Boryana Petrova

and Arzu Tugce Guler

submission deadline 20 Aug 2025 | Viewed by 118 | Submission Open

Keywords: metabolomics; MS imaging; machine learning; AI; multi-omics; integration; biomarker discovery; compound annotation; spectra interpretation

(This special issue belongs to the Section Bioinformatics and Data Analysis)

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