Current Advances and Methodologies in Gene Editing
A topical collection in Methods and Protocols (ISSN 2409-9279).
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Interests: mouse models; recombineering technology; CRISPR/Cas9 technology; Cas9-screens; dCas9-imaging; general regulation of transcription and epigenesis
Special Issues, Collections and Topics in MDPI journals
2. Yale-NUS College, 10 College Avenue West, Singapore 138609, Singapore
Interests: butterfly wing patterns; evo-devo; functional genetics; plasticity; eyespots; evolution; sexual and natural selection; behaviour
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear colleagues,
With the emergence of CRISPR/Cas9, an unprecedented variety of novel approaches and possibilities for genomic engineering are unveiled on a regular basis. These developments are accelerating the pace of research in model systems, as well as creating a plethora of emerging model systems invaluable for comparative functional approaches across the tree of life. The CRISPR/Cas9 toolbox has already allowed the manipulation of gene function in basal land plants, butterflies, crickets and Atlantic salmon, and many more are sure to follow.
This topical collection on “Gene Editing” aims to provide a forum for discussions on the latest technical developments in the fields of general genome engineering technologies, including (i) the establishment of cell culture systems, and (ii) the development of established and emerging organismal models by CRISPR/Cas9 or similar genome engineering tools. A constant flow of reports demonstrates the continuous refinement of the CRISPR/Cas9 revolutionary tool. Invariably, however, new challenges or missing details in the implementation of this technology become apparent when applied to specific model systems, which need to be addressed. Our topical collection aims to keep up with the most recent developments, refinements, and latest achievements in gene editing available today. We encourage contributions from laboratories working at the forefront of the development of novel CRISPR/Cas9 approaches, with the goal of sharing these details and accelerating the speed of functional genetic discovery across the tree of life, in well-established as well as in emerging model systems.
Dr. Philip Hublitz
Dr. Antónia Monteiro
Collection Editors
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Keywords
- CRISPR/Cas9
- Genome engineering
- Gene editing
- Established and emerging model systems
- Model generation
- Functional genetics using KI and KO
- Spatiotemporal regulation
- Arrayed and pooled sgRNA-Screening
- Cas9 efficiency and fidelity
- New tools in the CRISPR/Cas9 toolbox