Stimuli-Responsive Nanomaterials for Imaging and Therapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 502

Special Issue Editor


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Guest Editor
School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China
Interests: nanomedicine; nanozyme; responsive biomaterials; tumour; biofilm

Special Issue Information

Dear Colleagues,

Nanomaterials that can respond to chemical, physical, and biological stimuli have demonstrated great potential for imaging and treating diseases. Compared with traditional imaging and therapeutic agents used in medicine, stimuli-responsive nanoagents have the advantage of changing their morphology, structure, composition, size, and charge. The change in nanomaterials further alters their catalytic, optical, electrical, magnetic, acoustic, and mechanical properties, which can provide valuable information for detecting physiological and pathological changes in the body. Moreover, both internal and external stimuli can convert the physical and chemical change in nanomaterials to facilitate the release of drugs or generate reactive chemical species, heat, or vibrations to destroy cancer cells and pathogens. Thus, stimuli-responsive nanomaterials are very promising as next-generation imaging and therapeutic agents.

This Special Issue aims to call for reporting recent advances in stimuli-responsive nanomaterials for imaging and therapy, diagnosis, drug delivery, and the therapy of diseases in various fields, including cancer, infection, tissue engineering, interventional therapy, and so on. Research topics can include the preparation, assembly, surface modification, characterisation, and application of stimuli-responsive nanomaterials in imaging and therapy. Imaging modalities include but are not limited to magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), ultrasonography (US), fluorescent imaging (FLI), photoacoustic imaging (PAI), and so on. This Special Issue will cover various stimuli-responsive nanomaterials for drug delivery, chemodynamic therapy, photodynamic therapy, catalytic therapy, photothermal therapy, sonodynamic therapy, sonothermal therapy, etc. We invite the submission of manuscripts on experimental results from clinical, preclinical, animal, and cellular studies but are not limited to them.

Dr. Lihui Yuwen
Guest Editor

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Keywords

  • stimuli-responsive
  • nanomaterials
  • imaging
  • diagnostics
  • therapy
  • cancer
  • infection
  • tissue engineering

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Published Papers (1 paper)

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Research

14 pages, 7597 KiB  
Article
Magnetic Field/Ultrasound-Responsive Fe3O4 Microbubbles for Targeted Mechanical/Catalytic Removal of Bacterial Biofilms
by Liang Lu, Yuan Liu, Xiaolong Chen, Fengjiao Xu, Qi Zhang, Zhaowei Yin and Lihui Yuwen
Nanomaterials 2024, 14(22), 1830; https://doi.org/10.3390/nano14221830 - 15 Nov 2024
Viewed by 385
Abstract
Conventional antibiotics are limited by drug resistance, poor penetration, and inadequate targeting in the treatment of bacterial biofilm-associated infections. Microbubble-based ultrasound (US)-responsive drug delivery systems can disrupt biofilm structures and enhance antibiotic penetration through cavitation effects. However, currently developed US-responsive microbubbles still depend [...] Read more.
Conventional antibiotics are limited by drug resistance, poor penetration, and inadequate targeting in the treatment of bacterial biofilm-associated infections. Microbubble-based ultrasound (US)-responsive drug delivery systems can disrupt biofilm structures and enhance antibiotic penetration through cavitation effects. However, currently developed US-responsive microbubbles still depend on antibiotics and lack targeting capability. In this work, magnetic field/ultrasound (MF/US)-responsive Fe3O4 microbubbles (FMB) were constructed based on Fe3O4 nanoparticles (NPs) with superparamagnetic and peroxidase-like catalytic properties. In vitro experiments demonstrated that FMB can be targeted to methicillin-resistant Staphylococcus aureus (MRSA) biofilms by the direction of MF. Upon US irradiation, FMB collapse due to inertial cavitation and generate mechanical forces to disrupt the structure of MRSA biofilms and releases Fe3O4 NPs, which catalyze the generation of reactive oxygen species (ROS) from H2O2 in the biofilm microenvironment and kill the bacteria within the biofilm. In a mouse biofilm infection model, FMB efficiently destroyed MRSA biofilms grown in subcutaneous catheters with the MF and US. Magnetic-targeted mechanical/catalytic therapy based on FMB provides a promising strategy for effectively combating bacterial biofilm infection. Full article
(This article belongs to the Special Issue Stimuli-Responsive Nanomaterials for Imaging and Therapy)
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