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Nanomaterials
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The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications
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The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 10 December 2024 | Viewed by 5455

Special Issue Editor

Dr. Priyanka Singh

E-Mail Website
Guest Editor
The Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark
Interests: bio-nanotechnology; mettalic annoparticles; antimicorbial applications; biofilm; cancer; drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a comprehensive exploration of the background and history of antibacterial nanomaterials, highlighting their evolution and impact on biomedical applications. Over the years, these nanomaterials have emerged as pivotal players in the fight against antibiotic-resistant bacteria, revolutionizing the landscape of infection control. This Special Issue seeks to elucidate the historical trajectory that has brought us to the forefront of antibacterial nanomaterial research.

The primary objective of this Special Issue is to delineate the aim and scope of current research endeavors in the field of antibacterial nanomaterials. By presenting cutting-edge studies, we aim to showcase the latest innovations, breakthroughs, and challenges in the development and application of these nanomaterials. This Special Issue will serve as a platform to disseminate knowledge, foster collaboration, and guide future research directions within the dynamic realm of antibacterial nanomaterials.

Contributions to this Special Issue will encompass a spectrum of cutting-edge research articles, reviews, and perspectives. We invite submissions that delve into novel synthesis methods, characterization techniques, and innovative applications of antibacterial nanomaterials in various biomedical contexts. From the exploration of underlying mechanisms to the translation of research findings into practical solutions, we encourage submissions that span the breadth of antibacterial nanomaterial science.

We are soliciting papers that not only demonstrate scientific rigor but also provide valuable insights into the potential of antibacterial nanomaterials to address critical challenges in healthcare. Manuscripts elucidating the biocompatibility, toxicity profiles, and long-term safety aspects of these nanomaterials are particularly encouraged. Moreover, papers exploring the integration of antibacterial nanomaterials in real-world applications, such as medical devices, drug delivery systems, and wound healing, will significantly contribute to the richness of this Special Issue.

Dr. Priyanka Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial synthesis
  • biomedical applications
  • antibiotic resistance
  • cutting-edge research
  • drug delivery systems

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Published Papers (4 papers)

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Research

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17 pages, 3570 KiB  
Article
Biological Effects of Green Synthesized Al-ZnO Nanoparticles Using Leaf Extract from Anisomeles indica (L.) Kuntze on Living Organisms
by S. K. Johnsy Sugitha, R. Gladis Latha, Raja Venkatesan, Alexandre A. Vetcher, Nemat Ali and Seong-Cheol Kim
Nanomaterials 2024, 14(17), 1407; https://doi.org/10.3390/nano14171407 - 28 Aug 2024
Viewed by 1207
Abstract
The synthesis of Al-ZnO nanoparticles (NPs) was achieved using a green synthesis approach, utilizing leaf extract from Anisomeles indica (L.) in a straightforward co-precipitation method. The goal of this study was to investigate the production of Al-ZnO nanoparticles through the reduction and capping [...] Read more.
The synthesis of Al-ZnO nanoparticles (NPs) was achieved using a green synthesis approach, utilizing leaf extract from Anisomeles indica (L.) in a straightforward co-precipitation method. The goal of this study was to investigate the production of Al-ZnO nanoparticles through the reduction and capping method utilizing Anisomeles indica (L.) leaf extract. The powder X-ray diffraction, UV spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy with EDAX analysis were used to analyze the nanoparticles. X-ray diffraction analysis confirmed the presence of spherical structures with an average grain size of 40 nm in diameter, while UV–visible spectroscopy revealed a prominent absorption peak at 360 nm. FTIR spectra demonstrated the presence of stretching vibrations associated with O-H, N-H, C=C, C-N, and C=O as well as C-Cl groups indicating their involvement in the reduction and stabilization of nanoparticles. SEM image revealed the presence of spongy, spherical, porous agglomerated nanoparticles, confirming the chemical composition of Al-ZnO nanoparticles through the use of the EDAX technique. Al-ZnO nanoparticles showed increased bactericidal activity against both Gram-positive and Gram-negative bacteria. The antioxidant property of the green synthesized Al-ZnO nanoparticles was confirmed by DPPH radical scavenging with an IC50 value of 23.52 indicating excellent antioxidant capability. Green synthesized Al-ZnO nanoparticles were shown in in vivo studies on HeLa cell lines to be effective for cancer treatment. Additionally, α-amylase inhibition assay and α-glucosidase inhibition assay demonstrated their potent anti-diabetic activities. Moving forward, the current methodology suggests that the presence of phenolic groups, flavonoids, and amines in Al-ZnO nanoparticles synthesized with Anisomeles indica (L.) extract exhibit significant promise for eliciting biological responses, including antioxidant and anti-diabetic effects, in the realms of biomedical and pharmaceutical applications. Full article
(This article belongs to the Special Issue The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications)
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Review

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56 pages, 5775 KiB  
Review
Gold Nanoparticles in Nanomedicine: Unique Properties and Therapeutic Potential
by Furkan Eker, Emir Akdaşçi, Hatice Duman, Mikhael Bechelany and Sercan Karav
Nanomaterials 2024, 14(22), 1854; https://doi.org/10.3390/nano14221854 - 20 Nov 2024
Viewed by 716
Abstract
Gold nanoparticles (NPs) have demonstrated significance in several important fields, including drug delivery and anticancer research, due to their unique properties. Gold NPs possess significant optical characteristics that enhance their application in biosensor development for diagnosis, in photothermal and photodynamic therapies for anticancer [...] Read more.
Gold nanoparticles (NPs) have demonstrated significance in several important fields, including drug delivery and anticancer research, due to their unique properties. Gold NPs possess significant optical characteristics that enhance their application in biosensor development for diagnosis, in photothermal and photodynamic therapies for anticancer treatment, and in targeted drug delivery and bioimaging. The broad surface modification possibilities of gold NPs have been utilized in the delivery of various molecules, including nucleic acids, drugs, and proteins. Moreover, gold NPs possess strong localized surface plasmon resonance (LSPR) properties, facilitating their use in surface-enhanced Raman scattering for precise and efficient biomolecule detection. These optical properties are extensively utilized in anticancer research. Both photothermal and photodynamic therapies show significant results in anticancer treatments using gold NPs. Additionally, the properties of gold NPs demonstrate potential in other biological areas, particularly in antimicrobial activity. In addition to delivering antigens, peptides, and antibiotics to enhance antimicrobial activity, gold NPs can penetrate cell membranes and induce apoptosis through various intracellular mechanisms. Among other types of metal NPs, gold NPs show more tolerable toxicity capacity, supporting their application in wide-ranging areas. Gold NPs hold a special position in nanomaterial research, offering limited toxicity and unique properties. This review aims to address recently highlighted applications and the current status of gold NP research and to discuss their future in nanomedicine. Full article
(This article belongs to the Special Issue The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications)
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61 pages, 2281 KiB  
Review
Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects
by Hatice Duman, Emir Akdaşçi, Furkan Eker, Mikhael Bechelany and Sercan Karav
Nanomaterials 2024, 14(22), 1805; https://doi.org/10.3390/nano14221805 - 11 Nov 2024
Viewed by 575
Abstract
Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with distinctive physicochemical features. Their extraordinary optical properties, stemming from strong localized surface plasmon resonance (LSPR), contribute to the development of novel approaches in the areas of bioimaging, biosensing, [...] Read more.
Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with distinctive physicochemical features. Their extraordinary optical properties, stemming from strong localized surface plasmon resonance (LSPR), contribute to the development of novel approaches in the areas of bioimaging, biosensing, and cancer research, especially for photothermal and photodynamic therapy. The ease of functionalization with various ligands provides a novel approach to the precise delivery of these molecules to targeted areas. Gold NPs’ ability to transfer heat and electricity positions them as valuable materials for advancing thermal management and electronic systems. Moreover, their inherent characteristics, such as inertness, give rise to the synthesis of novel antibacterial and antioxidant agents as they provide a biocompatible and low-toxicity approach. Chemical and physical synthesis methods are utilized to produce gold NPs. The pursuit of more ecologically sustainable and economically viable large-scale technologies, such as environmentally benign biological processes referred to as green/biological synthesis, has garnered increasing interest among global researchers. Green synthesis methods are more favorable than other synthesis techniques as they minimize the necessity for hazardous chemicals in the reduction process due to their simplicity, cost-effectiveness, energy efficiency, and biocompatibility. This article discusses the importance of gold NPs, their optical, conductivity, antibacterial, antioxidant, and anticancer properties, synthesis methods, contemporary uses, and biosafety, emphasizing the need to understand toxicology principles and green commercialization strategies. Full article
(This article belongs to the Special Issue The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications)
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46 pages, 4934 KiB  
Review
Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications
by Furkan Eker, Hatice Duman, Emir Akdaşçi, Anna Maria Witkowska, Mikhael Bechelany and Sercan Karav
Nanomaterials 2024, 14(20), 1618; https://doi.org/10.3390/nano14201618 - 10 Oct 2024
Viewed by 2559
Abstract
Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The unique characteristics of silver NPs, such as their higher surface-area-to-volume ratio, make them ideal for a variety of [...] Read more.
Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The unique characteristics of silver NPs, such as their higher surface-area-to-volume ratio, make them ideal for a variety of biological applications. They are easily processed thanks to their large surface area, strong surface plasmon resonance (SPR), stable nature, and multifunctionality. With an emphasis on the mechanisms of action, efficacy, and prospective advantages of silver NPs, this review attempts to give a thorough overview of the numerous biological applications of these particles. The utilization of silver NPs in diagnostics, such as bioimaging and biosensing, as well as their functions in therapeutic interventions such as antimicrobial therapies, cancer therapy, diabetes treatment, bone repair, and wound healing, are investigated. The underlying processes by which silver NPs exercise their effects, such as oxidative stress induction, apoptosis, and microbial cell membrane rupture, are explored. Furthermore, toxicological concerns and regulatory issues are discussed, as well as the present difficulties and restrictions related to the application of silver NPs in medicine. Full article
(This article belongs to the Special Issue The Synthesis of Antibacterial Nanomaterials and Their Biomedical Applications)
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