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Nanomaterials
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Nanomaterials for Mass Spectrometry Applications
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Nanomaterials for Mass Spectrometry Applications

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 34708

Special Issue Editors

Prof. Dr. Nicola Cioffi

E-Mail Website1 Website2
Guest Editor
Chemistry Department, University of Bari “Aldo Moro”, 4 via Orabona, 70126 Bari, Italy
Interests: surface science; nanoantimicrobials; (nano)catalysts; chem- & bio-sensors; spectroscopy for chemical analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Rosaria Anna Picca

E-Mail Website
Guest Editor
Chemistry Department, University of Bari Aldo Moro, Via E. Orabona 4, IT-70125 Bari, Italy
Interests: nanomaterials; X-ray photoelectron spectroscopy; electrochemistry; antimicrobials; sensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Francesco Palmisano

E-Mail Website
Guest Editor
Dipartimento di Chimica, Campus Universitario, 70126 Bari, Italy
Interests: analytical chemistry; mass spectrometry applied to –omic science

Special Issue Information

Dear Colleagues,

This Special Issue is focused on both fundamental and application aspects of the use of Nanomaterials in Mass Spectrometry.

Topics include:

  • Nanomaterials as extraction tools/signal enhancers in mass spectrometry analysis of low-abundance species
  • Development of MS sub-techniques based on nanomaterials, such as SALDI-MS, NALDI-MS, SELDI-MS, etc.
  • Development of MS analysis protocols based on nanomaterials
  • Imaging MALDI-ToF-MS based on nanoparticles as labels/markers
  • Fundamentals of phenomena, such as nanoparticle ionization events, nanomaterial promotion of analyte’s ionization/desorption processes, nanoparticle-tissue interactions in MS applications, etc.

Studies specifically dealing with nanomaterials’ MS applications (in Food Science, Medicine, Omics fields, Materials Science, etc.) are also welcome.

Prof. Dr. Nicola Cioffi
Dr. Rosaria Anna Picca
Prof. Dr. Francesco Palmisano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • Mass Spectrometry
  • NALDI-MS
  • SALDI-MS
  • SELDI-MS
  • Imaging-MALDI-ToF-MS

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Published Papers (5 papers)

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Research

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6365 KiB  
Article
Comparison of Ti-Based Coatings on Silicon Nanowires for Phosphopeptide Enrichment and Their Laser Assisted Desorption/Ionization Mass Spectrometry Detection
by Ievgen Kurylo, Abderrahmane Hamdi, Ahmed Addad, Rabah Boukherroub and Yannick Coffinier
Nanomaterials 2017, 7(9), 272; https://doi.org/10.3390/nano7090272 - 15 Sep 2017
Cited by 8 | Viewed by 4488
Abstract
We created different TiO2-based coatings on silicon nanowires (SiNWs) by using either thermal metallization or atomic layer deposition (ALD). The fabricated surfaces were characterized by X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX), and reflectivity measurements. Surfaces with different TiO [...] Read more.
We created different TiO2-based coatings on silicon nanowires (SiNWs) by using either thermal metallization or atomic layer deposition (ALD). The fabricated surfaces were characterized by X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX), and reflectivity measurements. Surfaces with different TiO2 based coating thicknesses were then used for phosphopeptide enrichment and subsequent detection by laser desorption/ionization mass spectrometry (LDI-MS). Results showed that the best enrichment and LDI-MS detection were obtained using the silicon nanowires covered with 10 nm of oxidized Ti deposited by means of thermal evaporation. This sample was also able to perform phosphopeptide enrichment and MS detection from serum. Full article
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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5766 KiB  
Article
Performance of Electropun Polyacrylonitrile Nanofibrous Phases, Shown for the Separation of Water-Soluble Food Dyes via UTLC-Vis-ESI-MS
by Pimolpun Niamlang, Pitt Supaphol and Gertrud E. Morlock
Nanomaterials 2017, 7(8), 218; https://doi.org/10.3390/nano7080218 - 10 Aug 2017
Cited by 9 | Viewed by 4191
Abstract
Research in the miniaturization of planar chromatography led to various approaches in manufacturing ultrathin-layer chromatography (UTLC) layers of reduced thickness (<50 µm) along with smaller instrumentation, as targeted in Office Chromatography. This novel concept merges 3D print & media technologies with miniaturized planar [...] Read more.
Research in the miniaturization of planar chromatography led to various approaches in manufacturing ultrathin-layer chromatography (UTLC) layers of reduced thickness (<50 µm) along with smaller instrumentation, as targeted in Office Chromatography. This novel concept merges 3D print & media technologies with miniaturized planar chromatography to realize an all-in-one instrument, in which all steps of UTLC are automated and integrated in the same tiny device. In this context, the development of electrospun polyacrylonitrile (PAN) nanofiber phases was investigated as well as its performance. A nanofibrous stationary phase with fiber diameters of 150–225 nm and a thickness of ca. 25 µm was manufactured. Mixtures of water-soluble food dyes were printed on it using a modified office printer, and successfully separated to illustrate the capabilities of such UTLC media. The separation took 8 min for 30 mm and was faster (up to a factor of 2) than on particulate layers. The mean hRF values ranging from 25 to 90 for the five food dyes were well spread over the migration distance, with an overall reproducibility of 7% (mean %RSD over 5 different plates for 5 dyes). The individual mean plate numbers over 5 plates ranged between 8286 and 22,885 (mean of 11,722 over all 5 dyes). The single mean resolutions RS were between 1.7 and 6.5 (for the 5 food dyes over 5 plates), with highly satisfying reproducibilities (0.3 as mean deviation of RS). Using videodensitometry, different amounts separated in parallel led to reliable linear calibrations for each dye (sdv of 3.1–9.1% for peak heights and 2.4–9.3% for peak areas). Coupling to mass spectrometry via an elution head-based interface was successfully demonstrated for such ultrathin layers, showing several advantages such as a reduced cleaning process and a minimum zone distance. All these results underline the potential of electrospun nanofibrous phases to succeed as affordable stationary phase for quantitative UTLC. Full article
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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7735 KiB  
Article
A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging
by Silvia Giordano, Valentina Pifferi, Lavinia Morosi, Melinda Morelli, Luigi Falciola, Giuseppe Cappelletti, Sonja Visentin, Simonetta A. Licandro, Roberta Frapolli, Massimo Zucchetti, Roberta Pastorelli, Laura Brunelli, Maurizio D’Incalci and Enrico Davoli
Nanomaterials 2017, 7(3), 71; https://doi.org/10.3390/nano7030071 - 21 Mar 2017
Cited by 15 | Viewed by 5984
Abstract
The imaging of drugs inside tissues is pivotal in oncology to assess whether a drug reaches all cells in an adequate enough concentration to eradicate the tumor. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) is one of the most promising imaging techniques [...] Read more.
The imaging of drugs inside tissues is pivotal in oncology to assess whether a drug reaches all cells in an adequate enough concentration to eradicate the tumor. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) is one of the most promising imaging techniques that enables the simultaneous visualization of multiple compounds inside tissues. The choice of a suitable matrix constitutes a critical aspect during the development of a MALDI-MSI protocol since the matrix ionization efficiency changes depending on the analyte structure and its physico-chemical properties. The objective of this study is the improvement of the MALDI-MSI technique in the field of pharmacology; developing specifically designed nanostructured surfaces that allow the imaging of different drugs with high sensitivity and reproducibility. Among several nanomaterials, we tested the behavior of gold and titanium nanoparticles, and halloysites and carbon nanotubes as possible matrices. All nanomaterials were firstly screened by co-spotting them with drugs on a MALDI plate, evaluating the drug signal intensity and the signal-to-noise ratio. The best performing matrices were tested on control tumor slices, and were spotted with drugs to check the ion suppression effect of the biological matrix. Finally; the best nanomaterials were employed in a preliminary drug distribution study inside tumors from treated mice. Full article
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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Review

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2460 KiB  
Review
Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules
by Minghua Lu, Xueqing Yang, Yixin Yang, Peige Qin, Xiuru Wu and Zongwei Cai
Nanomaterials 2017, 7(4), 87; https://doi.org/10.3390/nano7040087 - 21 Apr 2017
Cited by 82 | Viewed by 11465
Abstract
Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 [...] Read more.
Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds. Full article
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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2325 KiB  
Review
Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
by Rosaria Anna Picca, Cosima Damiana Calvano, Nicola Cioffi and Francesco Palmisano
Nanomaterials 2017, 7(4), 75; https://doi.org/10.3390/nano7040075 - 2 Apr 2017
Cited by 74 | Viewed by 7469
Abstract
Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental [...] Read more.
Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques. Full article
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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