Multifunctional Magnetic Nanomaterials for Molecular Imaging and Therapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 October 2020) | Viewed by 3019

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Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain
Interests: nanomedicine; magnetic NPs; MRI; diagnosis; cancer therapy
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Special Issue Information

Dear Colleagues,

At present, one of the main objectives in the nanomedicine field is the development of a personalized medicine that enables an early diagnosis and individual treatment with the reduction of intake substances, thus reducing mortality and side adverse toxicity. Researchers are getting closer to this idea by synthesizing multifunctional magnetic nanomaterials in a single entity that enable the visualization and the follow-up of molecular processes at the cellular and molecular levels in living organisms with individual treatment, called theranostic as a combination of diagnosis and therapy.

In this manner, in this Special Issue, we want to focus on the latest original and novel results obtained in the synthesis of magnetic nanomaterials based on inorganic and/or organic nanoparticles (iron oxide-based nanoparticles, liposomes, micelles, etc.) with potential application as magnetic resonance imaging (MRI) contrast agents and also the possibility to use as therapeutic agents.

Dr. Manuel Pernia Leal
Guest Editor

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Keywords

  • magnetic nanomaterials
  • iron oxide nanoparticles
  • functionalization
  • MRI contrast agents
  • drug delivery
  • targeting
  • hyperthermia
  • diagnosis
  • therapy

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Published Papers (1 paper)

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Research

17 pages, 3721 KiB  
Article
Synergistical Use of Electrostatic and Hydrophobic Interactions for the Synthesis of a New Class of Multifunctional Nanohybrids: Plasmonic Magneto-Liposomes
by Gabriela Fabiola Știufiuc, Ștefan Nițică, Valentin Toma, Cristian Iacoviță, Dietrich Zahn, Romulus Tetean, Emil Burzo, Constantin Mihai Lucaciu and Rareș Ionuț Știufiuc
Nanomaterials 2019, 9(11), 1623; https://doi.org/10.3390/nano9111623 - 15 Nov 2019
Cited by 8 | Viewed by 2631
Abstract
By carefully controlling the electrostatic interactions between cationic liposomes, which already incorporate magnetic nanoparticles in the bilayers, and anionic gold nanoparticles, a new class of versatile multifunctional nanohybrids (plasmonic magneto-liposomes) that could have a major impact in drug delivery and controlled release applications [...] Read more.
By carefully controlling the electrostatic interactions between cationic liposomes, which already incorporate magnetic nanoparticles in the bilayers, and anionic gold nanoparticles, a new class of versatile multifunctional nanohybrids (plasmonic magneto-liposomes) that could have a major impact in drug delivery and controlled release applications has been synthesized. The experimental results confirmed the successful synthesis of hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) and polyethylene glycol functionalized (PEGylated) gold nanoparticles (AuNPs). The SPIONs were incorporated in the liposomal lipidic bilayers, thus promoting the formation of cationic magnetoliposomes. Different concentrations of SPIONs were loaded in the membrane. The cationic magnetoliposomes were decorated with anionic PEGylated gold nanoparticles using electrostatic interactions. The successful incorporation of SPIONs together with the modifications they generate in the bilayer were analyzed using Raman spectroscopy. The plasmonic properties of the multifunctional nanohybrids were investigated using UV-Vis absorption and (surface-enhanced) Raman spectroscopy. Their hyperthermic properties were recorded at different frequencies and magnetic field intensities. After the synthesis, the nanosystems were extensively characterized in order to properly evaluate their potential use in drug delivery applications and controlled release as a result of the interaction with an external stimulus, such as an NIR laser or alternating magnetic field. Full article
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