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Nutritional and Metabolic Changes Affecting Adipose Tissue Biology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 2028

Special Issue Editors


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Guest Editor
Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), 28922 Madrid, Spain
Interests: obesity; type 2 diabetes; adipose tissue; inflammation; lipotoxicity; metabolism
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), 28922 Madrid, Spain
Interests: obesity; ageing; lipotoxicity; metabolism; adipose tissue; pregnancy

Special Issue Information

Dear Colleagues,

An adequate nutritional balance is key to maintaining a healthy metabolic status. Besides obvious genetic predisposition, alterations in lifestyles affect adipose tissue biology, promoting the development of metabolic disorders.

White and brown adipose tissue are recognized as key endocrine organs involved in metabolism. Some research studies have focused on the metabolic alterations in adipose tissue in obesity, but novel research deciphering their role in other processes that require metabolic adaptations is crucial to furthering new therapeutic options.

This Special Issue, titled ‘Nutritional and Metabolic Changes Affecting Adipose Tissue Biology’, aims to provide new insight into the field from the perspective of nutrition and metabolism to promote a healthy status.

Dr. David Sánchez-Infantes
Dr. Patricia Corrales
Guest Editors

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Keywords

  • nutrition
  • adipose tissue
  • metabolism

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Published Papers (1 paper)

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Research

17 pages, 5065 KiB  
Article
A Mixture of Lactobacillus HY7601 and KY1032 Regulates Energy Metabolism in Adipose Tissue and Improves Cholesterol Disposal in High-Fat-Diet-Fed Mice
by Kippeum Lee, Hyeon-Ji Kim, Joo-Yun Kim, Jae-Jung Shim and Jae-Hwan Lee
Nutrients 2024, 16(15), 2570; https://doi.org/10.3390/nu16152570 - 5 Aug 2024
Viewed by 1623
Abstract
We aimed to characterize the anti-obesity and anti-atherosclerosis effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 using high-fat diet (HFD)-fed obese C57BL/6 mice. We divided the mice into control (CON), HFD, HFD with 108 CFU/kg/day probiotics (HFD + KL, HY7301:KY1032 = [...] Read more.
We aimed to characterize the anti-obesity and anti-atherosclerosis effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 using high-fat diet (HFD)-fed obese C57BL/6 mice. We divided the mice into control (CON), HFD, HFD with 108 CFU/kg/day probiotics (HFD + KL, HY7301:KY1032 = 1:1), and HFD with 109 CFU/kg/day probiotics (HFD + KH, HY7301:KY1032 = 1:1) groups and fed/treated them during 7 weeks. The body mass, brown adipose tissue (BAT), inguinal white adipose tissue (iWAT), and epididymal white adipose tissue (eWAT) masses and the total cholesterol and triglyceride concentrations were remarkably lower in probiotic-treated groups than in the HFD group in a dose-dependent manner. In addition, the expression of uncoupling protein 1 in the BAT, iWAT, and eWAT was significantly higher in probiotic-treated HFD mice than in the HFD mice, as demonstrated by immunofluorescence staining and Western blotting. We also measured the expression of cholesterol transport genes in the liver and jejunum and found that the expression of those encoding liver-X-receptor α, ATP-binding cassette transporters G5 and G8, and cholesterol 7α-hydroxylase were significantly higher in the HFD + KH mice than in the HFD mice. Thus, a Lactobacillus HY7601 and KY1032 mixture with 109 CFU/kg/day concentration can assist with body weight regulation through the management of lipid metabolism and thermogenesis. Full article
(This article belongs to the Special Issue Nutritional and Metabolic Changes Affecting Adipose Tissue Biology)
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