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Nutrients
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What Is Proper Nutrition for Kidney Diseases?
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What Is Proper Nutrition for Kidney Diseases?

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 5 March 2025 | Viewed by 2987

Special Issue Editor

Prof. Dr. Masashi Mizuno

E-Mail Website
Guest Editor
Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Interests: adequate nutritional managements; effects of nutritional managements; nutritional status in kidney diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

What is proper nutrition to manage patients with chronic kidney diseases (CKD)?

In CKD patients, nutritional management is carried out with the aim of preventing its progression to ESKD, preventing complications associated with CKD, and replenishing the essential nutrients in just the right amount. However, with the recent aging of the global society, the aim of preventing sarcopenia has become important, requiring consideration, and the concept of dietary restrictions has undergone a change.

Presently, it is important not only to prevent the progression of the disease and live longer but also to consider treatment methods that take QOL into account so that patients can stay healthy. It seems that the appropriateness and meaning of nutritional guidance are also changing. Particularly, the degree of the restriction of protein intake has been recently under discussion for CKD patients with/without hemodialysis or peritoneal dialysis. We need to consider several factors associated with the nutritional status of patients with renal diseases.

The present Special Issue would like to invite both original and review articles that focus on the improvement of renal function and/or the prevention of renal function reduction through dietary interventions, not only during the preservative period of chronic renal failure but also in acute kidney injury and chronic glomerulonephritis and that focus on nutritional evaluations to achieve good nutritional status in dialysis patients, especially the elderly dialysis patients

Prof. Dr. Masashi Mizuno
Guest Editor

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Keywords

  • chronic kidney disease
  • acute kidney disease
  • renal function
  • protein restriction
  • elementary intake
  • rare metal
  • protein intake
  • hemodialysis
  • peritoneal dialysis
  • renal transplantation

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Published Papers (2 papers)

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Research

17 pages, 3267 KiB  
Article
Dietary Probiotic Pediococcus acidilactici GKA4, Dead Probiotic GKA4, and Postbiotic GKA4 Improves Cisplatin-Induced AKI by Autophagy and Endoplasmic Reticulum Stress and Organic Ion Transporters
by Jaung-Geng Lin, Wen-Ping Jiang, You-Shan Tsai, Shih-Wei Lin, Yen-Lien Chen, Chin-Chu Chen and Guan-Jhong Huang
Nutrients 2024, 16(20), 3532; https://doi.org/10.3390/nu16203532 - 18 Oct 2024
Viewed by 1298
Abstract
Background/Objectives: Acute kidney injury (AKI) syndrome is distinguished by a quick decline in renal excretory capacity and usually diagnosed by the presence of elevated nitrogen metabolism end products and/or diminished urine output. AKI frequently occurs in hospital patients, and there are no existing [...] Read more.
Background/Objectives: Acute kidney injury (AKI) syndrome is distinguished by a quick decline in renal excretory capacity and usually diagnosed by the presence of elevated nitrogen metabolism end products and/or diminished urine output. AKI frequently occurs in hospital patients, and there are no existing specific treatments available to diminish its occurrence or expedite recovery. For an extended period in the food industry, Pediococcus acidilactici has been distinguished by its robust bacteriocin production, effectively inhibiting pathogen growth during fermentation and storage. Methods: In this study, the aim is to assess the effectiveness of P. acidilactici GKA4, dead probiotic GKA4, and postbiotic GKA4 against cisplatin-induced AKI in an animal model. The experimental protocol involves a ten-day oral administration of GKA4, dead probiotic GKA4, and postbiotic GKA4 to mice, with a cisplatin intraperitoneal injection being given on the seventh day to induce AKI. Results: The findings indicated the significant alleviation of the renal histopathological changes and serum biomarkers of GKA4, dead probiotic GKA4, and postbiotic GKA4 in cisplatin-induced nephrotoxicity. GKA4, dead probiotic GKA4, and postbiotic GKA4 elevated the expression levels of HO-1 and decreased the expression levels of Nrf-2 proteins. In addition, the administration of GKA4, dead probiotic GKA4, and postbiotic GKA4 significantly reduced the expression of apoptosis-related proteins (Bax, Bcl-2, and caspase 3), autophagy-related proteins (LC3B, p62, and Beclin1), and endoplasmic reticulum (ER) stress-related proteins (GRP78, PERK, ATF-6, IRE1, CHOP, and Caspase 12) in kidney tissues. Notably, GKA4, dead probiotic GKA4, and postbiotic GKA4 also upregulated the levels of proteins related to organic anion transporters and organic cation transporters. Conclusions: Overall, the potential therapeutic benefits of GKA4, dead probiotic GKA4, and postbiotic GKA4 are significant, particularly after cisplatin treatment. This is achieved by modulating apoptosis, autophagy, ER stress, and transporter proteins to alleviate oxidative stress. Full article
(This article belongs to the Special Issue What Is Proper Nutrition for Kidney Diseases?)
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10 pages, 252 KiB  
Article
Phosphorus Knowledge and Dietary Intake of Phosphorus of US Adults Undergoing Dialysis
by Sydney T. Schneider, Alexander Klug and Jeanette M. Andrade
Nutrients 2024, 16(13), 2034; https://doi.org/10.3390/nu16132034 - 27 Jun 2024
Viewed by 1322
Abstract
Abnormal serum phosphorus is a concern for adults undergoing dialysis due to the risk for mortality and morbidity. General recommendations for maintaining serum phosphorus within normal limits is monitoring dietary intake of phosphorus and taking phosphate binders, as prescribed. However, limited research is [...] Read more.
Abnormal serum phosphorus is a concern for adults undergoing dialysis due to the risk for mortality and morbidity. General recommendations for maintaining serum phosphorus within normal limits is monitoring dietary intake of phosphorus and taking phosphate binders, as prescribed. However, limited research is available about adults’ phosphorus knowledge and dietary intake of phosphorus. The purpose of this cross-sectional study was to determine the association between phosphorus knowledge and dietary intake of phosphorus of adults on dialysis. An online Qualtrics survey was conducted during February–September 2023. Participants (n = 107) responded to the 74-item questionnaire (30-day food frequency questionnaire, phosphorus knowledge questionnaire, and demographic questions). Analysis included frequencies, descriptive statistics, t-tests, and Spearman correlations. JMP SAS v16 was used with a statistical significance of p < 0.05. Of the participants, 57.0% (n = 61) were on peritoneal dialysis and 43.0% (n = 46) were on hemodialysis. Average phosphorus knowledge score was 10.6 ± 3.0 out of 19 or 55.8%, with those on peritoneal dialysis having lower scores (54.7%) compared to participants on hemodialysis (58.1%) (p < 0.05). The daily average dietary phosphorus intake was 605 ± 297 mg. Participants on peritoneal dialysis consumed more phosphorus (625 mg) compared to participants on hemodialysis (576 mg) (p < 0.05). There was no association with phosphorus knowledge scores and dietary intake of phosphorus. There were positive correlations between discussing about phosphorus, knowing serum phosphorus concentration, and phosphorus knowledge scores. These results can aid practitioners in providing tailored nutrition education among adults on dialysis. Full article
(This article belongs to the Special Issue What Is Proper Nutrition for Kidney Diseases?)
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