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Nutrients
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Effects of Plant Extracts on Human Health—2nd Edition
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Effects of Plant Extracts on Human Health—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 1830

Special Issue Editors

Prof. Dr. Fátima Regina Mena Barreto Silva

E-Mail Website
Guest Editor
1. Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
2. Laboratory of Biochemistry and Pharmacology, Departament of Pharmacology and Physiology, Drug Research and Development Center (DRDC), Medical School, Federal University of Ceará, Rua Coronel Nunes de Melo, Fortaleza 60430-275, CE, Brazil
Interests: natural compounds; diabetes; infertility; cancer; central nervous system diseases; chronic diseases; medicinal plants; pain and analgesia
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Diana Marcela Aragon Novoa

E-Mail Website
Guest Editor
Departamento de Farmácia, Facultad de Ciencias, Universidad Nacional de Colombia, Cra. 30 45-03, Bogotá 111321, DC, Colombia
Interests: drug delivery system; microparticles; nanoparticles; self-emulsifying delivery; pharmacokinetics; extracts standardization; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue titled "Effects of Plant Extracts on Human Health—2nd Edition" in Nutrients. This issue aims to explore the diverse impacts of plant extracts on human health, spanning from their nutritional value to their potential therapeutic effects/nutraceuticals.

We invite researchers, scientists, and experts to contribute their original research and reviews to this Special Issue. Submissions may include, but are not limited to, studies investigating the following:

  • The bioactive compounds present in plant extracts;
  • The mechanisms underlying the health effects of plant extracts;
  • The role of plant extracts in preventing or treating various health conditions;
  • The potential synergistic effects of combining different plant extracts;
  • The utilization of plant extracts in functional foods and nutraceuticals.

We encourage submissions that utilize diverse methodologies, including in vitro and in vivo studies, clinical trials, and meta-analyses, to provide comprehensive insights into the effects of plant extracts on human health.

We look forward to receiving your contributions and to the collective advancement of knowledge in this important area of research.

Prof. Dr. Fátima Regina Mena Barreto Silva
Prof. Dr. Diana Marcela Aragon Novoa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • human health
  • bioactive compounds
  • therapeutic effects
  • nutraceuticals

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Published Papers (2 papers)

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Research

10 pages, 2475 KiB  
Article
Potential Effect of Cinnamaldehyde on Insulin Resistance Is Mediated by Glucose and Lipid Homeostasis
by Marisa Jadna Silva Frederico, Paola Miranda Sulis, Landerson Lopes Pereira, Diana Rey, Marcela Aragón and Fátima Regina Mena Barreto Silva
Nutrients 2025, 17(2), 297; https://doi.org/10.3390/nu17020297 - 15 Jan 2025
Viewed by 586
Abstract
Diabetes mellitus is a metabolic syndrome that has grown globally to become a significant public health challenge. Hypothesizing that the plasma membrane protein, transient receptor potential ankyrin-1, is a pivotal target in insulin resistance, we investigated the mechanism of action of cinnamaldehyde (CIN), [...] Read more.
Diabetes mellitus is a metabolic syndrome that has grown globally to become a significant public health challenge. Hypothesizing that the plasma membrane protein, transient receptor potential ankyrin-1, is a pivotal target in insulin resistance, we investigated the mechanism of action of cinnamaldehyde (CIN), an electrophilic TRPA1 agonist, in skeletal muscle, a primary insulin target. Specifically, we evaluated the effect of CIN on insulin resistance, hepatic glycogen accumulation and muscle and adipose tissue glucose uptake. Furthermore, the in vitro role of CIN in glucose uptake and intracellular signaling was determined in insulin-resistant rats whose calcium influx was analyzed. Moreover, the serum lipid profile was assessed following short-term CIN treatment in rats, and lipid tolerance was analyzed. The effects of CIN on insulin resistance were mediated by TRPA1, with downstream signaling involving the activation of PI3-K, MAPK, PKC, as well as extracellular calcium and calcium release from intracellular stores. Additionally, cytoskeleton integrity was required for the complete action of CIN on glucose uptake in muscle. CIN also ameliorated the serum lipid profile and improved triglyceride tolerance following acute vivo exposure. Full article
(This article belongs to the Special Issue Effects of Plant Extracts on Human Health—2nd Edition)
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17 pages, 1287 KiB  
Article
Efficacy and Satisfaction of a Chemically Characterized Malva sylvestris L. Extract-Based Food Supplement for Functional Constipation in Healthy Consumers: Preliminary Results of a Questionnaire-Based Survey
by Lorenza Francesca De Lellis, Hammad Ullah, Maria Vittoria Morone, Daniele Giuseppe Buccato, Alessandra Baldi, Alessandro Di Minno, Danaé S. Larsen, Roberto Sacchi and Maria Daglia
Nutrients 2025, 17(1), 77; https://doi.org/10.3390/nu17010077 - 28 Dec 2024
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Abstract
Background/Objectives: Malva sylvestris L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in [...] Read more.
Background/Objectives: Malva sylvestris L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in the absence of pathological abnormalities. FC can be reduced through lifestyle factors and dietary intervention. This consumer-based survey aimed to assess the efficacy of a M. sylvestris extract-based food supplement on the improvement of FC. Methods: Healthy participants (n = 56), enrolled in a consumer-based survey, took a food supplement containing a chemically characterized M. sylvestris extract at a dose of 20 mL/day (containing 750 mg of M. sylvestris extract rich in food fiber and polyphenols) for 20 days on the advice of their pharmacist. The study evaluated bowel movement frequency (intestinal diary), stool consistency (Bristol Stool Form Scale, BSFS), and abdominal pain (Visual Analogue Scale, VAS), at baseline (T0), after 10 days (T1), and after 20 days (T2). Results: A significant increase in bowel movement frequency and stool consistency (p < 0.001) with a significant decrease in abdominal pain (p < 0.001) was observed. Additionally, this food supplement was well-tolerated as no adverse effects were reported by the enrolled subjects. Conclusion: M. sylvestris-based food supplement showed promising effectiveness and satisfaction in improving FC in healthy subjects, however, randomized clinical studies are needed to confirm these preliminary results. Full article
(This article belongs to the Special Issue Effects of Plant Extracts on Human Health—2nd Edition)
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