Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.2
4.8
Journals
Nutrients
Special Issues
The Role of Nutrition on Bone Health and Skeletal Development...
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Role of Nutrition on Bone Health and Skeletal Development in Older Adults

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 22310

Special Issue Editors

Prof. Dr. Jun Il I. Yoo

E-Mail Website
Guest Editor
1. Department of Orthopedics, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea
2. Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea
Interests: sarcopenia; osteoporosis; hip fracture; nutrition
Dr. Heewon Jung

E-Mail Website
Guest Editor
1. Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
2. Hospital Medicine Center, Seoul National University Hospital, Seoul, Republic of Korea
3. Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Seoul 05556, Songpa-gu, Republic of Korea
Interests: sarcopenia; osteoporosis; nutrition

Special Issue Information

Dear Colleagues,

In recent years, as the aging population increases, the health of bone and muscle is becoming more important. When osteoporosis and sarcopenia occur in the elderly, the incidence of fractures increases, which is an important causative disease that sharply reduces the quality of life for the rest of one’s life. Therefore, interest in nutrients and healthy functional foods for bone and muscle has recently increased. However, too much information and misinformation caused by corporate advertisements is often floating around the Internet. The purpose of this Special Issue is to provide readers with accurate, valuable, and up-to-date information on nutrients for bone and muscle.

As the Guest Editors of this Special Issue on “The Role of Nutrition on Bone Health and Skeletal Development in Older Adults”, we hope to further contribute to this fascinating area of metabolism by inviting you to submit a manuscript to Nutrients to improve our knowledge regarding the role of macronutrients in bone tissue function and metabolism. Experimental research, systematic and meta-analyses, and narrative reviews are welcome.

Prof. Dr. Jun Il I. Yoo
Dr. Heewon Jung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • bone
  • osteoporosis
  • skeletal development

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 711 KiB  
Article
Prognostic Value of New Sarcopenia Screening Tool in the Elderly—SARC-GLOBAL
by Ana Carolina Costa Vicedomini, Dan L. Waitzberg, Natalia Correia Lopes, Natalia Magalhães, Ana Paula A. Prudêncio, Wilson Jacob Filho, Alexandre Leopold Busse, Douglas Ferdinando, Tatiana Pereira Alves, Rosa Maria Rodrigues Pereira and Giliane Belarmino
Nutrients 2024, 16(11), 1717; https://doi.org/10.3390/nu16111717 - 31 May 2024
Viewed by 1271
Abstract
Sarcopenia screening tools have a low capacity to predict adverse outcomes that are consequences of sarcopenia in the elderly population. This study aimed to evaluate the ability of a new sarcopenia screening tool SARC-GLOBAL to predict negative clinical outcomes in the elderly. A [...] Read more.
Sarcopenia screening tools have a low capacity to predict adverse outcomes that are consequences of sarcopenia in the elderly population. This study aimed to evaluate the ability of a new sarcopenia screening tool SARC-GLOBAL to predict negative clinical outcomes in the elderly. A total of 395 individuals were evaluated in a 42-month period. The screening tools SARC-GLOBAL, SARC-F, and SARC-CalF and the diagnosis of sarcopenia according to European Working Group on Sarcopenia in Older Persons (EWGSOP2) were performed at the beginning of the study. Logistic and Poisson regression models were applied to assess the predictive value of the tools for the odds and risks of negative clinical outcomes, respectively. The most common negative clinical outcome in the followed population was falls (12.9%), followed by infections (12.4%), hospitalizations (11.8%), fractures (4.3%), and deaths (2.7%). Both SARC-GLOBAL and SARC-F were similar in predicting the odds of falls and hospitalizations during the follow up period, however SARC-CalF only predicted the odds of hospitalizations at 42 months. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Figure 1

15 pages, 3081 KiB  
Article
The Association between Obesity and Reduced Weight-Adjusted Bone Mineral Content in Older Adults: A New Paradigm That Contrasts with the Obesity Paradox
by Antonino De Lorenzo, Massimo Pellegrini, Paola Gualtieri, Leila Itani, Giulia Frank, Marwan El Ghoch and Laura Di Renzo
Nutrients 2024, 16(3), 352; https://doi.org/10.3390/nu16030352 - 25 Jan 2024
Cited by 2 | Viewed by 1710
Abstract
The relationship between body weight and bone mass in the elderly remains unclear, and whether obesity is a protective factor is still a matter of debate. For this reason, the aim of this study is to assess the association between body mass index [...] Read more.
The relationship between body weight and bone mass in the elderly remains unclear, and whether obesity is a protective factor is still a matter of debate. For this reason, the aim of this study is to assess the association between body mass index (BMI) and bone mineral content adjusted by body weight, expressed as a percentage (w-BMC%), and to test the validity of the obesity paradox in this context. A cohort of 1404 older adults was categorized according to the World Health Organization’s BMI cut-off points and completed a total and segmental body composition measurement by means of a dual X-ray absorptiometry scan. Individuals with obesity displayed a lower mean w-BMC% (3.06 ± 0.44%; 2.60 ± 0.37%) compared to those who were normal-weight (3.95 ± 0.54%; 3.38 ± 0.48%) and overweight (3.06 ± 0.44%; 3.04 ± 0.37%) in both genders. Linear regression analysis also showed a negative association between BMI and w-BMC% in males (β = −0.09; p < 0.001) and females (β = −0.06; p < 0.001). Finally, among individuals with obesity, and after adjusting for age, the linear regression models revealed a significant decrease of 0.75% and 0.28% in w-BMC% for every one-unit increase in the trunk fat/appendicular lean mass ratio in both males (β = −0.749; p < 0.0001) and females (β = −0.281; p < 0.001). In conclusion, we suggest a new paradigm regarding the impact of obesity on bone mass, in which the former does not appear to be a protective factor of the latter, especially in individuals with central obesity and low muscle mass. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Figure 1

13 pages, 2729 KiB  
Article
Euonymus alatus (Thunb.) Siebold Prevents Osteoclast Differentiation and Osteoporosis
by Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Dong Ryun Gu, Hyun Yang, Jin Ah Ryuk and Hyunil Ha
Nutrients 2023, 15(18), 3996; https://doi.org/10.3390/nu15183996 - 15 Sep 2023
Cited by 2 | Viewed by 1204
Abstract
Euonymus alatus (Thunb.) Siebold, a traditional medicinal plant, has been used in China and several other Asian countries to address a variety of health concerns. The extensive research conducted on E. alatus is driven by its diverse pharmacological applications. However, its biological effects [...] Read more.
Euonymus alatus (Thunb.) Siebold, a traditional medicinal plant, has been used in China and several other Asian countries to address a variety of health concerns. The extensive research conducted on E. alatus is driven by its diverse pharmacological applications. However, its biological effects on osteoclastogenesis and osteoporosis have not been previously studied. In this research, we investigated the impact of an ethanolic extract of E. alatus (EEEA) on osteoclast differentiation and function as well as estrogen deficiency-induced bone loss. We found that EEEA inhibits osteoclast differentiation by downregulating the expression of the receptor activator of nuclear factor-κB ligand (RANKL) in osteoclast-supporting cells and by directly impeding RANKL-mediated signaling pathways for osteoclastogenesis in precursor cells. In addition, EEEA inhibited the bone-resorptive function of mature osteoclasts in vitro. Furthermore, oral administration of EEEA significantly alleviated bone loss in an ovariectomy-induced osteoporosis mouse model. Additionally, we identified phytochemicals in EEEA that have suppressive effects on osteoclast differentiation and bone loss. Collectively, these results suggest that EEEA holds potential as a biotherapeutic candidate for anti-postmenopausal osteoporosis. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Graphical abstract

12 pages, 2640 KiB  
Article
Effects of Whey Protein Supplement on 4-Week Resistance Exercise-Induced Improvements in Muscle Mass and Isokinetic Muscular Function under Dietary Control
by Chae-Been Kim, Jong-Hoon Park, Hyoung-Su Park, Hye-Jin Kim and Jung-Jun Park
Nutrients 2023, 15(4), 1003; https://doi.org/10.3390/nu15041003 - 16 Feb 2023
Cited by 6 | Viewed by 11142
Abstract
(1) The purpose of this study was to investigate the effect of whey protein supplementation under dietary control on improvements in muscle mass and function following resistance exercise training. (2) Thirty-two men were randomly assigned to a whey protein supplementation group taking whey [...] Read more.
(1) The purpose of this study was to investigate the effect of whey protein supplementation under dietary control on improvements in muscle mass and function following resistance exercise training. (2) Thirty-two men were randomly assigned to a whey protein supplementation group taking whey protein isolate (PSG, n = 17) and a placebo group (CON, n = 15). Participants were provided with three meals per day corresponding to the estimated individual daily energy intake. The supervised resistance exercise program was conducted 60 min per day, six days per week, for four weeks. (3) Post-intervention, there was a significant interaction between groups in terms of muscle mass increase (p = 0.033, η2 = 0.14), with a greater increase in the PSG. There were also significant interactions between the groups and increases in peak torque of the dominant knee flexors (p = 0.048, η2 = 0.12), dominant shoulder extensors, and non-dominant shoulder extensors (p = 0.028, η2 = 0.15; p = 0.015, η2 = 0.18), and the total work of the dominant knee and shoulder extensors (p = 0.012, η2 = 0.19; p = 0.013, η2 = 0.19), with greater increases in the PSG. (4) These results suggest that whey protein supplementation enhances resistance exercise-induced increase in muscle mass and overall muscular strength and endurance, independent of dietary influence. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Figure 1

Review

Jump to: Research

19 pages, 4851 KiB  
Review
How to Suppress Mineral Loss and Stimulate Anabolism in Postmenopausal Bones with Appropriate Timing of Exercise and Nutrients
by Katarina T. Borer
Nutrients 2024, 16(6), 759; https://doi.org/10.3390/nu16060759 - 7 Mar 2024
Cited by 1 | Viewed by 4160
Abstract
Background. Bone Health and Osteoporosis Foundation (BHOF) reports that as of 2023, approximately 10 million of older Americans have osteoporosis and another 44 million have low bone density. Osteoporosis is a serious handicap for the elderly and, in particular, for estrogen-deficient postmenopausal [...] Read more.
Background. Bone Health and Osteoporosis Foundation (BHOF) reports that as of 2023, approximately 10 million of older Americans have osteoporosis and another 44 million have low bone density. Osteoporosis is a serious handicap for the elderly and, in particular, for estrogen-deficient postmenopausal women, as it increases the risk of debilitating bone weakness and fractures. The BHOF recommendations for prevention of osteopenia, osteoporosis and bone fractures are to perform weight-bearing and muscle-strengthening exercises and to take recommended amounts of daily calcium and vitamin D. Methods. The purpose of this review is to describe and discuss recent evidence-based research on how to effectively utilize timing of exercise and calorie intake for stimulation of postmenopausal bone anabolism, and to provide this new information in the form of specific and actionable recommendations. Results. The five evidence-based recommendations are as follows: 1. Select an appropriate circadian time of day for exercise; 2. Increase walking speed to raise the movement momentum; 3. Eat a weight-maintenance meal one or two hours before the exercise bout; 4. Sustain the duration of walking activity (impulse) for 40 to 45 min; and 5. Repeat effective exercise stimulus 7 to 8 h after the first one to double the anabolic effect. Osteogenesis can also be increased with subthreshold mechanical loading, where needed, under several special circumstances. Conclusions. This review should provide pragmatic actionable pointers on how to utilize the idiosyncratic bone responsiveness to timing of movement and meals to prevent osteoporosis and encourage research toward a better understanding of how bone detects adequacy of a mechanical stimulus and determines duration of necessary rest to recover its sensitivity to mechanical stimulation and nutrients. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Figure 1

58 pages, 939 KiB  
Review
The Influences of Macronutrients on Bone Mineral Density, Bone Turnover Markers, and Fracture Risk in Elderly People: A Review of Human Studies
by Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo and Yoona Kim
Nutrients 2023, 15(20), 4386; https://doi.org/10.3390/nu15204386 - 16 Oct 2023
Cited by 1 | Viewed by 1975
Abstract
Osteoporosis is a health condition that involves weak bone mass and a deteriorated microstructure, which consequently lead to an increased risk of bone fractures with age. In elderly people, a fracture attributable to osteoporosis elevates mortality. The objective of this review was to [...] Read more.
Osteoporosis is a health condition that involves weak bone mass and a deteriorated microstructure, which consequently lead to an increased risk of bone fractures with age. In elderly people, a fracture attributable to osteoporosis elevates mortality. The objective of this review was to examine the effects of macronutrients on bone mineral density (BMD), bone turnover markers (BTMs), and bone fracture in elderly people based on human studies. A systematic search was conducted in the PubMed®/MEDLINE® database. We included human studies published up to April 2023 that investigated the association between macronutrient intake and bone health outcomes. A total of 11 meta-analyses and 127 individual human studies were included after screening the records. Carbohydrate consumption seemed to have neutral effects on bone fracture in limited studies, but human studies on carbohydrates’ effects on BMD or/and BTMs are needed. The human studies analyzed herein did not clearly show whether the intake of animal, vegetable, soy, or milk basic proteins has beneficial effects on bone health due to inconsistent results. Moreover, several individual human studies indicated an association between eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and osteocalcin. Further studies are required to draw a clear association between macronutrients and bone health in elderly people. Full article
(This article belongs to the Special Issue The Role of Nutrition on Bone Health and Skeletal Development in Older Adults)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop