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Physiology and Pathophysiology of Iron Metabolism—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 5 November 2025 | Viewed by 1812

Special Issue Editor


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Guest Editor
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
Interests: iron metabolism; hematology; hemostaseology; molecular genetics; carbohydrate metabolism; applied biomarker research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The goal of this Special Issue, “Physiology and Pathophysiology of Iron Metabolism—2nd Edition”, is to focus on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health.

Specifically, the aim of this Special Issue is to give an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body.

Considering the success of the previous Special Issue entitled "Physiology and Pathophysiology of Iron Metabolism", we are pleased to announce that we are launching a second Special Issue on this topic. This actual information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism for the readership of this journal.

Dr. Dietmar Enko
Guest Editor

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Keywords

  • iron
  • iron metabolism
  • iron regulator proteins
  • intestinal iron resorption
  • body iron stores
  • iron deficiency
  • nutritional factors of iron homeostasis
  • iron overload disorders
  • hereditary disorders of iron metabolism

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Published Papers (1 paper)

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Research

20 pages, 4105 KiB  
Article
Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2
by Kendra A. Klag, Rickesha Bell, Xuan Jia, Alexandra Seguin, J. Alan Maschek, Mary Bronner, James E. Cox, June L. Round and Diane M. Ward
Nutrients 2024, 16(12), 1804; https://doi.org/10.3390/nu16121804 - 8 Jun 2024
Viewed by 1402
Abstract
Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbiota status. Changes in either [...] Read more.
Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbiota status. Changes in either iron or the microbiome are tightly correlated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD). To investigate the underlying mechanisms of the development of MASLD that connect altered iron metabolism and gut microbiota, we compared specific pathogen free (SPF) or germ-free (GF) mice, fed a normal or low-iron diet. SPF mice on a low-iron diet showed reduced serum triglycerides and MASLD. In contrast, GF low-iron diet-fed mice showed increased serum triglycerides and did not develop hepatic steatosis. SPF mice showed significant changes in liver lipid metabolism and increased insulin resistance that was dependent upon the presence of the gut microbiota. We report that total body loss of mitochondrial iron importer Mitoferrin2 (Mfrn2/) exacerbated the development of MASLD on a low-iron diet with significant lipid metabolism alterations. Our study demonstrates a clear contribution of the gut microbiome, dietary iron, and Mfrn2 in the development of MASLD and metabolic syndrome. Full article
(This article belongs to the Special Issue Physiology and Pathophysiology of Iron Metabolism—2nd Edition)
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