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The Role of Nutrition in Eye Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (17 May 2023) | Viewed by 8170

Special Issue Editor


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Guest Editor
Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, Kilinskiego 1, 15-089 Białystok, Poland
Interests: eye; dry eye disease; diabetic retinopathy; myopia; obesity; children
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Special Issue Information

Dear Colleagues,

The goal of this Special Issue, “The Role of Nutrition in Eye Health”, is to focus on the importance of nutrition in maintaining ocular health.

Specifically, the aim is to clarify if diet can prevent and treat ocular diseases. 

This new information will provide ophthalmologists and eye care professionals with widespread and updated evidence on the role of diet in ocular diseases and the potential role of nutritional strategies in improving eye health.

Prof. Dr. Malgorzata Mrugacz
Guest Editor

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Keywords

  • nutrition
  • eye
  • dry eye disease
  • diabetic retinopathy
  • myopia
  • obesity
  • age macular degeneration
  • cataract

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Published Papers (3 papers)

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Research

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12 pages, 2618 KiB  
Article
Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model
by Tsung-Han Lu, Jun-Way Chang, Bo-Yi Jhou, Jui-Hsia Hsu, Tsung-Ju Li, Li-Ya Lee, Yen-Lien Chen, Han-Hsin Chang, Chin-Chu Chen, Pey-Shiuan Wu and David Pei-Cheng Lin
Nutrients 2023, 15(14), 3103; https://doi.org/10.3390/nu15143103 - 11 Jul 2023
Cited by 1 | Viewed by 2379
Abstract
Cataracts, a prevalent age-related eye condition, pose a significant global health concern, with rising rates due to an aging population and increased digital device usage. In Taiwan, cataract prevalence is particularly high, reaching up to 90% among individuals aged 70 and above. The [...] Read more.
Cataracts, a prevalent age-related eye condition, pose a significant global health concern, with rising rates due to an aging population and increased digital device usage. In Taiwan, cataract prevalence is particularly high, reaching up to 90% among individuals aged 70 and above. The lens of the eye absorbs short-wave light, which can lead to oxidative stress in lens epithelial cells and contribute to cataract formation. Exposure to ultraviolet (UV) light further exacerbates the risk of cataracts by generating reactive oxygen species. Heat-shock proteins (HSPs), involved in protein maintenance and repair, have been linked to cataract development. Cordyceps cicadae (C. cicadae), a traditional Chinese medicine, has a long history of use and is known for its pharmacological effects. N6-(2-hydroxyethyl) adenosine (HEA), a bioactive compound found in C. cicadae, exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties. Previous studies have shown that C. cicadae mycelial extracts improve dry eye disease and reduce intraocular pressure in animal models. Additionally, C. cicadae possesses antioxidant properties, which are beneficial for combating cataract formation. In this study, we aim to evaluate the preventive efficacy of C. cicadae mycelial extracts in UV-induced cataract development. By investigating the ameliorative effects of C. cicadae on eye diseases and its potential role in ocular health improvement, we hope to uncover new options for cataract prevention and provide insights into the mechanisms of action. The findings of this research could provide a novel approach for nutritional supplements targeting cataract prevention, offering potential benefits in the field of ocular health. Full article
(This article belongs to the Special Issue The Role of Nutrition in Eye Health)
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13 pages, 698 KiB  
Article
Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study
by Cristina Peris-Martínez, José Vicente Piá-Ludeña, María José Rog-Revert, Ester Fernández-López and Joan Carles Domingo
Nutrients 2023, 15(5), 1300; https://doi.org/10.3390/nu15051300 - 6 Mar 2023
Cited by 11 | Viewed by 3820
Abstract
A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% [...] Read more.
A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography. Full article
(This article belongs to the Special Issue The Role of Nutrition in Eye Health)
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Review

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37 pages, 1118 KiB  
Review
Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems
by Xiaoyuan Ye, Nicholas Siu Kay Fung, Wai Ching Lam and Amy Cheuk Yin Lo
Nutrients 2024, 16(11), 1715; https://doi.org/10.3390/nu16111715 - 30 May 2024
Viewed by 1470
Abstract
Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage [...] Read more.
Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications. Full article
(This article belongs to the Special Issue The Role of Nutrition in Eye Health)
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