Dietary Cholesterol and Human Health
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: closed (15 April 2021) | Viewed by 7382
Special Issue Editors
Interests: genetics; epigenetics; exosomes; endocrinology
Special Issues, Collections and Topics in MDPI journals
Interests: assessment of dietary intake; health and nutrition education; prevention and rehabilitation from chronic diseases in children and adults; functional foods
Special Issues, Collections and Topics in MDPI journals
2. Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece
Interests: nutrition; cardiovascular diseases; nutritional epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cholesterol homeostasis in the body is governed by cholesterol absorption, synthesis, storage, and excretion. Dietary cholesterol is a nutrient of major concern and is considered a basic determinant of blood cholesterol levels. It has recently become a controversial issue, with studies showing that high consumption of dietary cholesterol or eggs are associated with a higher risk of developing cardiovascular disease, independently of the quality and quantity of fat ingested. Processed foods are rich in nutrients such as choline, iron, carnitine and added sodium, ingredients that are involved in the risk of developing cardiovascular disease through a variety of metabolic pathways. These effects should be taken into account for the development of new directions for dietary cholesterol intake.
In recent guidelines, recommendations to decrease cholesterol intake have raised questions about cholesterol’s role in atherosclerosis and cardiovascular disease. Thus, the relevance of dietary cholesterol regulation for human heart health remains unclear.
Recent data on lipoprotein metabolism have shown that additional lipoprotein measures, including high HDL-cholesterol levels, high ratio of LDL-/HDL- cholesterol, very low levels of apolipoproteins B and A, as well as low LDL-cholesterol, have been suggested for risk assessment and disease prognosis. Thus, hyperlipoproteinemia and hypolipidemia should be taken into account. The appropriateness of these markers for risk assessment and treatment targets can be influenced by nutritional management.
In this Special Issue, we aim to elucidate the effect of dietary patterns on atherosclerosis risk factors and to explore the role of diet-related disease progression and the effect of dietary lipids on the expression of genes involved in diverse dyslipidaemias. We hope that this issue will advance our understanding of how cholesterol-containing nutrients are related to endogenous and exogenous pathways of cholesterol disorders.
Prof. George P. Chrousos
Prof. Yannis Manios
Prof. Dr. Antonis Zampelas
Guest Editors
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Keywords
- diet cholesterol
- atherosclerosis
- dyslipidemias
- nutrients
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