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Nutrients
Special Issues
Nutritional Approaches to Regulate Oxidative Stress and Prevent Chronic Disease
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Nutritional Approaches to Regulate Oxidative Stress and Prevent Chronic Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (5 June 2024) | Viewed by 10343

Special Issue Editor

Dr. Emma Borrelli

E-Mail Website
Guest Editor
Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy
Interests: redox modulator; ozone therapy; oxidative stress in chronic diseases; antioxidants; anti-inflammatory agents; gaseous signaling molecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce that we are organizing a new Special Issue whose goal is to compile evidence on how nutrition strategies can regulate oxidative stress and prevent chronic disease.

A large number of investigations have indicated that dietary intervention may hold promising potential in the prevention and management of chronic diseases. For example, antioxidant supplements or exogenous redox modulators could be useful in restoring oxidant/antioxidant balance in cardiovascular diseases, chronic lung diseases, and neurological degenerative diseases. Moreover, it has been reported that oxidative stress and/or a decrease in antioxidant defense systems could lead to changes in general inflammation and dysregulation of the immune system. Antioxidants/polyphenolic antioxidant-containing foods may offer promising preventive and therapeutic benefits in chronic diseases due to their ability to target multiple physiological areas.

We invite authors to submit review articles and original research describing the possible nutritional approaches and innovative interventions in the management of oxidative stress in chronic diseases.

We welcome original research articles, animal and clinical studies, as well as review articles.

Dr. Emma Borrelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidant-containing food
  • chronic diseases
  • redox modulation

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Published Papers (3 papers)

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Research

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17 pages, 1950 KiB  
Article
Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)
by Preeti Sarkar, Alessandra Pecorelli, Brittany Woodby, Erika Pambianchi, Francesca Ferrara, Raj Kumar Duary and Giuseppe Valacchi
Nutrients 2023, 15(4), 1035; https://doi.org/10.3390/nu15041035 - 19 Feb 2023
Cited by 11 | Viewed by 2566
Abstract
Food-derived bioactive peptides (BAPs) obtained from edible insect-protein hold multiple activities promising the potential to target complex pathological mechanisms responsible for chronic health conditions such as hypertension development. In this study, enzymatic protein hydrolysates from non-mulberry edible silkworm Antheraea assama (Muga) and Philosomia [...] Read more.
Food-derived bioactive peptides (BAPs) obtained from edible insect-protein hold multiple activities promising the potential to target complex pathological mechanisms responsible for chronic health conditions such as hypertension development. In this study, enzymatic protein hydrolysates from non-mulberry edible silkworm Antheraea assama (Muga) and Philosomia ricini (Eri) pupae, specifically Alcalase (A. assama) and Papain (P. ricini) hydrolysates obtained after 60 and 240 min, exhibited the highest ACE-inhibitory and antioxidant properties. The hydrolysates’ fractions (<3, 3–10 and >10 kDa), specifically Alc_M60min_F3 (≤3 kDa) and Pap_E240min_F3 (≤3 kDa), showed the highest antioxidant and ACE-inhibitory activities, respectively. Further RP-HPLC purified sub-fractions F4 and F6 showed the highest ACE inhibition as well as potent anti-oxinflammatory activities in lipopolysaccharide (LPS)-treated endothelial cells. Indeed, F4 and F6 ACE-inhibitory peptide fractions were effective in preventing p65 nuclear translocation after 3 h of LPS stimulation along with the inhibition of p38 MAPK phosphorylation in HUVEC cells. In addition, pretreatment with F4 and F6 ACE-inhibitory peptide fractions significantly prevented the LPS-induced upregulation of COX-2 expression and IL-1β secretion, while the expression of NRF2 (nuclear factor erythroid 2-related factor 2)-regulated enzymes such as HO-1 and NQO1 was induced by both peptide fractions. The derived peptides from edible pupae protein hydrolysates have potentialities to be explored as nutritional approaches against hypertension and related cardiovascular diseases. Full article
(This article belongs to the Special Issue Nutritional Approaches to Regulate Oxidative Stress and Prevent Chronic Disease)
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17 pages, 4647 KiB  
Article
Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pathway in Mice
by Liqun Wang, Manyu Zhao, Rui Qian, Mengzhu Wang, Qixue Bao, Xuxi Chen, Wen Du, Ling Zhang, Tinghong Ye, Yongmei Xie, Ben Zhang, Lijun Peng and Yuqin Yao
Nutrients 2023, 15(1), 143; https://doi.org/10.3390/nu15010143 - 28 Dec 2022
Cited by 6 | Viewed by 4967
Abstract
Nicotinamide mononucleotide (NMN) is a natural antioxidant approved as a nutritional supplement and food ingredient, but its protective role in silicosis characterized by oxidative damage remains unknown. In this study, we generated a silicosis model by intratracheal instillation of silica, and then performed [...] Read more.
Nicotinamide mononucleotide (NMN) is a natural antioxidant approved as a nutritional supplement and food ingredient, but its protective role in silicosis characterized by oxidative damage remains unknown. In this study, we generated a silicosis model by intratracheal instillation of silica, and then performed histopathological, biochemical, and transcriptomic analysis to evaluate the role of NMN in silicosis. We found that NMN mitigated lung damage at 7 and 28 days, manifested as a decreasing coefficient of lung weight and histological changes, and alleviated oxidative damage by reducing levels of reactive oxygen species and increasing glutathione. Meanwhile, NMN treatment also reduced the recruitment of inflammatory cells and inflammatory infiltration in lung tissue. Transcriptomic analysis showed that NMN treatment mainly regulated immune response and glutathione metabolism pathways. Additionally, NMN upregulated the expression of antioxidant genes Gstm1, Gstm2, and Mgst1 by promoting the expression and nuclear translocation of nuclear factor-erythroid 2 related factor 2 (Nrf2). Gene interaction analysis showed that Nrf2 interacted with Gstm1 and Mgst1 through Gtsm2. Promisingly, oxidative damage mediated by these genes occurred mainly in fibroblasts. In summary, NMN alleviates silica-induced oxidative stress and lung injury by regulating the endogenous glutathione metabolism pathways. This study reveals that NMN supplementation might be a promising strategy for mitigating oxidative stress and inflammation in silicosis. Full article
(This article belongs to the Special Issue Nutritional Approaches to Regulate Oxidative Stress and Prevent Chronic Disease)
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Review

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22 pages, 1195 KiB  
Review
Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming
by You-Lin Tain and Chien-Ning Hsu
Nutrients 2024, 16(5), 683; https://doi.org/10.3390/nu16050683 - 28 Feb 2024
Cited by 2 | Viewed by 1868
Abstract
Metabolic syndrome (MetS) denotes a constellation of risk factors associated with the development of cardiovascular disease, with its roots potentially traced back to early life. Given the pivotal role of oxidative stress and dysbiotic gut microbiota in MetS pathogenesis, comprehending their influence on [...] Read more.
Metabolic syndrome (MetS) denotes a constellation of risk factors associated with the development of cardiovascular disease, with its roots potentially traced back to early life. Given the pivotal role of oxidative stress and dysbiotic gut microbiota in MetS pathogenesis, comprehending their influence on MetS programming is crucial. Targeting these mechanisms during the early stages of life presents a promising avenue for preventing MetS later in life. This article begins by examining detrimental insults during early life that impact fetal programming, ultimately contributing to MetS in adulthood. Following that, we explore the role of oxidative stress and the dysregulation of gut microbiota in the initiation of MetS programming. The review also consolidates existing evidence on how gut-microbiota-targeted interventions can thwart oxidative-stress-associated MetS programming, encompassing approaches such as probiotics, prebiotics, postbiotics, and the modulation of bacterial metabolites. While animal studies demonstrate the favorable effects of gut-microbiota-targeted therapy in mitigating MetS programming, further clinical investigations are imperative to enhance our understanding of manipulating gut microbiota and oxidative stress for the prevention of MetS. Full article
(This article belongs to the Special Issue Nutritional Approaches to Regulate Oxidative Stress and Prevent Chronic Disease)
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