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Pharmaceutics
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Microporous and Mesoporous Materials and Their Derived Hybrids as Systems...
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Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (10 February 2022) | Viewed by 28181

Special Issue Editors

Dr. Jacobo Hernández Montelongo

E-Mail Website
Guest Editor
Departamento de Ciencias Matemáticas y Físicas, Facultad de Ingeniería, Universidad Católica de Temuco, Temuco, La Araucanía, Chile
Interests: biomaterials; porous materials; biopolymers; hybrids; nanostructured materials; nanofilms; controlled release
Dr. Miguel Manso Silván

E-Mail Website
Co-Guest Editor
Departamento de Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
Interests: preparation, functionalization and applications of biocompatible mesoporous semiconductors

Special Issue Information

Dear Colleagues,

In recent decades, a diversity of materials such as polymers, ceramics, and semiconductors have been used as controlled release systems. Among the most versatile materials, microporous and mesoporous materials stand out due to their high surface areas and tailorable surface chemistry. Depending on the size and surface functionalization of the pores, increased or sustained controlled release of a loaded molecule can be obtained. Moreover, if these micro- and mesoporous materials are inorganic, hybrids can be synthetized through a combination with organic compounds such as biopolymers. Engineered hybrid materials exhibit new advantageous chemical and physical characteristics, which are not exhibited by the individual constituents. Particularly, improved control over drug release kinetics, enhanced stability in different media, and selective release can be achieved by gating the pores with responsive molecules.

Microporous- and mesoporous-based materials and their derived hybrids work for several molecules such as drugs, proteins, genes, fertilizers, nutrients, salts, and other biologically active agents.

Dr. Jacobo Hernández Montelongo
Dr. Miguel Manso Silván
Guest Editors

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Keywords

  • microporous
  • mesoporous
  • hybrids
  • controlled release
  • drug delivery

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Published Papers (6 papers)

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Research

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20 pages, 4050 KiB  
Article
Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-βCD Composites Improves Their Antiangiogenic Activity
by Dina Guzmán-Oyarzo, Jacobo Hernández-Montelongo, Carlos Rosas, Pamela Leal, Helga Weber, Marysol Alvear and Luis A. Salazar
Pharmaceutics 2022, 14(3), 484; https://doi.org/10.3390/pharmaceutics14030484 - 22 Feb 2022
Cited by 6 | Viewed by 2144
Abstract
Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is [...] Read more.
Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-βCD composite microparticles. For this HUVEC, cells were exposed to H2O2 and to treatments with polyphenols in solution and loaded in the composite microparticle. The polyphenols were incorporated into a microparticle using nanoporous silicon, chitosan and a β-cyclodextrin polymer as the biomaterial. The evaluation of the antiangiogenic effect of the treatments with polyphenols in solution and microencapsulated was carried out through functional tests, and the changes in the expression of target genes associated with the antioxidant pathway and angiogenesis was performed through qPCR. The results obtained show that the caffeic acid and pinocembrin have an antioxidant and antiangiogenic activity, both in solution as microencapsulated. In the caffeic acid, a greater biological effect was observed when it was incorporated into the nPSi-βCD composite microparticle. Our results suggest that the nPSi-βCD composite microparticle could be used as an alternative oral drug administration system. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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16 pages, 2509 KiB  
Article
Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica
by Adrianna Dadej, Aneta Woźniak-Braszak, Paweł Bilski, Hanna Piotrowska-Kempisty, Małgorzata Józkowiak, Małgorzata Geszke-Moritz, Michał Moritz, Daniela Dadej and Anna Jelińska
Pharmaceutics 2021, 13(10), 1693; https://doi.org/10.3390/pharmaceutics13101693 - 15 Oct 2021
Cited by 6 | Viewed by 2374
Abstract
The effectiveness of oral drug administration is related to the solubility of a drug in the gastrointestinal tract and its ability to penetrate the biological membranes. As most new drugs are poorly soluble in water, there is a need to develop novel drug [...] Read more.
The effectiveness of oral drug administration is related to the solubility of a drug in the gastrointestinal tract and its ability to penetrate the biological membranes. As most new drugs are poorly soluble in water, there is a need to develop novel drug carriers that improve the dissolution rate and increase bioavailability. The aim of this study was to analyze the modification of sulindac release profiles in various pH levels with two APTES ((3-aminopropyl)triethoxysilane)-modified SBA-15 (Santa Barbara Amorphous-15) silicas differing in 3-aminopropyl group content. Furthermore, we investigated the cytotoxicity of the analyzed molecules. The materials were characterized by differential scanning calorimetry, powder X-ray diffraction, scanning and transmission electron microscopy, proton nuclear magnetic resonance and Fourier transformed infrared spectroscopy. Sulindac loaded on the SBA-15 was released in the hydrochloric acidic medium (pH 1.2) and phosphate buffers (pH 5.8, 6.8, and 7.4). The cytotoxicity studies were performed on Caco-2 cell line. The APTES-modified SBA-15 with a lower adsorption capacity towards sulindac released the drug in a less favorable manner. However, both analyzed materials improved the dissolution rate in acidic pH, as compared to crystalline sulindac. Moreover, the SBA-15, both before and after drug adsorption, exhibited insignificant cytotoxicity towards Caco-2 cells. The presented study evidenced that SBA-15 could serve as a non-toxic drug delivery system that enhances the dissolution rate of sulindac and improves its bioavailability. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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19 pages, 3597 KiB  
Article
Silane Modification of Mesoporous Materials for the Optimization of Antiviral Drug Adsorption and Release Capabilities in Vaginal Media
by Elena Whittle, Araceli Martín-Illana, Raul Cazorla-Luna, Fernando Notario-Perez, María Dolores Veiga-Ochoa, Juan Rubio and Aitana Tamayo
Pharmaceutics 2021, 13(9), 1416; https://doi.org/10.3390/pharmaceutics13091416 - 7 Sep 2021
Cited by 4 | Viewed by 3100
Abstract
Three different functionalities have been incorporated into mesoporous materials by means of a coupling reaction with the siloxanes 3-glycidoxypropyl-trimethoxysilane (GLYMO), 3-methacryloxypropyl-trimethoxysilane (MEMO), and 3-mercaptopropyl-trimethoxysilane (MPTMS). The disposition of the different functional groups, as well as the interaction mechanism, with the mesoporous substrate has [...] Read more.
Three different functionalities have been incorporated into mesoporous materials by means of a coupling reaction with the siloxanes 3-glycidoxypropyl-trimethoxysilane (GLYMO), 3-methacryloxypropyl-trimethoxysilane (MEMO), and 3-mercaptopropyl-trimethoxysilane (MPTMS). The disposition of the different functional groups, as well as the interaction mechanism, with the mesoporous substrate has been identified. The amount of the antiviral drug acyclovir (ACV) adsorbed depends not only on the available surface area but also on the chemical or physicochemical interactions between functionalities. The drug adsorption isotherm of the materials functionalized with GLYMO and MPTMS follow mechanisms dependent on the different surface coverage and the possibilities to establish physicochemical interactions between the drug molecule and the functionalities. On the contrary, when functionalizing with MEMO, the dominant adsorption mechanism is characteristic of chemically bonded adsorbates. The ACV release kinetics is best fitted to the Weibull model in all the functionalized materials. When the MTPMS is used as a functionalizing agent, the drug diffusion occurs at low kinetics and homogeneously along the mesoporous channels. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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15 pages, 2826 KiB  
Article
Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
by José L. M. Gonçalves, Ana Beatriz C. Lopes, Carlos Baleizão and José Paulo S. Farinha
Pharmaceutics 2021, 13(5), 716; https://doi.org/10.3390/pharmaceutics13050716 - 13 May 2021
Cited by 9 | Viewed by 2959
Abstract
Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the system was optimized by [...] Read more.
Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the system was optimized by a novel approach using selective functionalization of the silica pores to tune the carrier-cargo interaction and by tunning the amount of grafted polymer. The system features excellent retention of cationic cargo at low pH and a burst release at higher pH. This results from the expanded-collapsed conformation transition of the pH-responsive polymer shell and the simultaneous change in the interaction between the cargo and the polymer shell and the modified pore walls. At low pH, the electrostatic interaction of the cationic cargo with the protonated amine groups of the extended polymer shell retains the cargo, resulting in very low leakage (OFF state). At high pH, the electrostatic interaction with the cargo is lost (due to deprotonation of the polymer amine groups), and the polymer shell collapses, squeezing out the cargo in a burst release (ON state). Pore functionalization in combination with the stimuli-responsive polymer shell is a very promising strategy to design high-performance ON:OFF smart hybrid nanocarriers for stimuli-actuated cargo release, with great potential for application in the controlled release of drugs and other biologically active agents. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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Review

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56 pages, 71077 KiB  
Review
An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine
by Elham Rastegari, Yu-Jer Hsiao, Wei-Yi Lai, Yun-Hsien Lai, Tien-Chun Yang, Shih-Jen Chen, Pin-I Huang, Shih-Hwa Chiou, Chung-Yuan Mou and Yueh Chien
Pharmaceutics 2021, 13(7), 1067; https://doi.org/10.3390/pharmaceutics13071067 - 12 Jul 2021
Cited by 73 | Viewed by 11648
Abstract
The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances [...] Read more.
The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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19 pages, 2359 KiB  
Review
Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy
by Thashini Moodley and Moganavelli Singh
Pharmaceutics 2021, 13(1), 71; https://doi.org/10.3390/pharmaceutics13010071 - 7 Jan 2021
Cited by 45 | Viewed by 4555
Abstract
With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies [...] Read more.
With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials and Their Derived Hybrids as Systems for Controlled Release)
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