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Natural Phenolic and Polyphenolic Compounds and Their Impact on Human...
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Natural Phenolic and Polyphenolic Compounds and Their Impact on Human Health

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 4342

Special Issue Editors

Dr. Octavian Tudorel Olaru

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Department of Pharmaceutical Botany and Cell Biology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: anticancer research; pharmaceutical botany; pharmacognosy; alternative toxicology testing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Nitulescu George Mihai

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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: animals of pharmacology and toxicology; invertebrate animals; computational models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, polyphenols have gained significant attention from researchers due to their health benefits and their large distribution in plants. The in vitro and in vivo preclinical studies on a large variety of plant extracts or specific isolated compounds showed the considerable pharmacological potential of this group of natural compounds. They demonstrated the ability of natural phenolic and polyphenolic compounds to positively impact processes such as inflammation, immunity, the cardiovascular system, and the nervous system, among others. Their pharmacological activity is determined by the wide range of chemical structures as polyphenols are categorized into several classes, including flavonoids, coumarins, phenolic acids, tannins, lignans, and stilbenes. This large chemical variety is also reflected in their biological effects profile, and supports the need for extensive studies in order to better understand and capitalize on these classes of compounds.

We encourage all researchers to send manuscripts related to polyphenols, including research on isolated compounds or plant extracts. We welcome various study designs, including preclinical and clinical studies, observational and in silico studies. The use of modern methodologies will be highly appreciated. Original research articles and specialized critical reviews are welcome.

Dr. Octavian Tudorel Olaru
Prof. Dr. Nitulescu George Mihai
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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18 pages, 7468 KiB  
Article
Optimization and Characterization of Phenolic Extraction Conditions and Antioxidant Activity Evaluation of Adenanthera pavonina L. Bark
by Syeda Nurunnesa Begum, Mobarok Hossain, Md. Adnan, Chowdhury Habibur Rahaman and Arif Reza
Plants 2023, 12(22), 3902; https://doi.org/10.3390/plants12223902 - 19 Nov 2023
Cited by 5 | Viewed by 1478
Abstract
The presence of high levels of secondary metabolites in medicinal plants can significantly influence the progress of drug development. Here, we aimed to maximize phenolic extraction from Adenanthera pavonina L. stem bark using various solvents such as ethyl acetate, methanol, petroleum ether, and [...] Read more.
The presence of high levels of secondary metabolites in medicinal plants can significantly influence the progress of drug development. Here, we aimed to maximize phenolic extraction from Adenanthera pavonina L. stem bark using various solvents such as ethyl acetate, methanol, petroleum ether, and chloroform. A response surface method (RSM) with a central composite design (CCD) statistical technique was applied to optimize the extraction process, employing three important extracting parameters such as extraction time (h), temperature (°C), and solvent composition (% v/v of methanol/water) to obtain the highest phenolic content. Total phenolic content (TPC) and antioxidant activity (IC50 of extract’s DPPH radical scavenging activity) were used as response variables to find the influence of these extracting parameters. Among the various solvents used, methanol extract showed the highest contents of phenolics and the maximum level of antioxidant activity with a lower IC50 value. The notable TPC and IC50 value of the extract’s DPPH radical scavenging capacity were found to be 181.69 ± 0.20 mg GAE/g dry tissue and 60.13 ± 0.11 mg/mL, respectively, under the optimal conditions with a solvent composition of 71.61% (v/v) of methanol/water, extraction temperature of 42.52 °C, and extraction time of 24 h. The optimized extract of A. pavonina stem bark was further subjected to HPLC analysis, where six phenolic compounds, including coumarin, p-coumaric acid, chlorogenic acid, sinapic acid, gallic acid, and caffeic acid, were identified along with their respective quantities. Overall, the findings of this study uncover a low-cost analytical model for maximizing phenolic extraction from A. pavonina bark with enhanced antioxidant activity. Full article
(This article belongs to the Special Issue Natural Phenolic and Polyphenolic Compounds and Their Impact on Human Health)
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Review

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16 pages, 637 KiB  
Review
Resveratrol and Other Natural Oligomeric Stilbenoid Compounds and Their Therapeutic Applications
by Cosmina-Gabriela Duta-Bratu, George Mihai Nitulescu, Dragos Paul Mihai and Octavian Tudorel Olaru
Plants 2023, 12(16), 2935; https://doi.org/10.3390/plants12162935 - 14 Aug 2023
Cited by 21 | Viewed by 2435
Abstract
The use of natural compounds as an alternative to synthetic molecules has become a significant subject of interest in recent decades. Stilbenoids are a group of phenolic compounds found in many plant species and they have recently gained the focus of a multitude [...] Read more.
The use of natural compounds as an alternative to synthetic molecules has become a significant subject of interest in recent decades. Stilbenoids are a group of phenolic compounds found in many plant species and they have recently gained the focus of a multitude of studies in medicine and chemistry, resveratrol being the most representative molecule. In this review, we focused on the research that illustrates the therapeutic potential of this class of natural molecules considering various diseases with higher incidence rates. PubChem database was searched for bioactivities of natural stilbenoids, while several keywords (i.e., “stilbenoids”, “stilbenoid anticancer”) were used to query PubMed database for relevant studies. The diversity and the simplicity of stilbenes’ chemical structures together with the numerous biological sources are key elements that can simplify both the isolation of these compounds and the drug design of novel bioactive molecules. Resveratrol and other related compounds are heterogeneously distributed in plants and are mainly found in grapes and wine. Natural stilbenes were shown to possess a wide range of biological activities, such as antioxidant, anti-inflammatory, antihyperglycemic, cardioprotective, neuroprotective, and antineoplastic properties. While resveratrol is widely investigated for its benefits in various disorders, further studies are warranted to properly harness the therapeutic potential of less popular stilbenoid compounds. Full article
(This article belongs to the Special Issue Natural Phenolic and Polyphenolic Compounds and Their Impact on Human Health)
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