Resistance to Staphylococcus aureus Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 37426
Special Issue Editor
Interests: chronic infections; diabetic foot ulcers; recurrent urinary tract infections; microbiota; virulence; resistance; diagnostic tool; alternative treatments
Special Issue Information
Dear Colleagues,
Staphylococcus aureus is a commensal microorganism that is often present asymptomatically on parts of the human body. S. aureus is also a major human pathogen able to adapt to diverse hosts and environmental conditions, and to cause diverse infections (e.g., bloodstream infections, endocarditis, skin and soft tissue infections, osteomyelitis, lower respiratory tract). S. aureus is equipped with a collection of virulence factors and toxins, often making it responsible for many toxin-mediated diseases.
A WHO report on ‘Antimicrobial resistance: global report on surveillance’ highlights that the methicillin-resistant S. aureus (MRSA) strains remain a public health problem and a threat to humans associated with high morbidity, mortality, and socioeconomic costs. Antibiotic resistance is a global crisis, which urgently requires alternative strategies to standard antibiotic therapy. MRSA was associated with healthcare settings, the so-called hospital-associated MRSA (HA-MRSA). More recently, community-acquired MRSA (CA-MRSA) infections have been rising in frequency, and now MRSA strains also represent a major cause of community-associated infections. CA-MRSA is genetically distinct from HA-MRSA, being resistant to fewer antibiotics, carrying a smaller trait of SCCmec, and often producing the Panton–Valentine leukocidin. Moreover, CA-MRSA invading healthcare settings has been also identified as the etiological agent of nosocomial outbreaks.
This Special Issue aims to characterize and discuss the pathogenesis of S. aureus infection; the epidemiology of virulence content of MRSA; the physiopathology and clinical aspects of the virulence (notably the toxinogenic markers) in MRSA; the evolution of resistance and virulence determinants during the infections; the genetic adaptation of S. aureus to antibiotics and its environment; and the in vitro, ex vivo, and in vivo impacts of antibiotics or alternative strategies on S. aureus virulence. Discussions can be proposed in the light to limit antibiotic used and discover new alternative therapeutic solutions to fight against S. aureus virulence and reduce antibiotic resistance.
Prof. Dr. Jean-Philippe Lavigne
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- S. aureus
- MRSA
- Pathogenesis
- Genetic adaptation
- Antibiotic resistance
- Virulence
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
