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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioinformatics-Driven Analysis of Mechanisms Underlying the Function and Evolution of Pandemic Viruses

edited by

Francesco Filippini

and

Irene Righetto

submission deadline 25 Apr 2025 | 1 articles | Viewed by 14775 | Submission Open

Keywords: pandemic virus; avian influenza; coronavirus; SARS-CoV-2; immune escape; structural bioinformatics; variant; mutation; antiviral design; host jump; pathogenicity shift; antiviral design; epitope identification

(This special issue belongs to the Section General Virology)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 25 Apr 2025 | 2 articles | Viewed by 2459 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 25 Apr 2025 | Viewed by 174 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Advances in Endemic and Emerging Viral Diseases in Livestock

edited by

Fernando Vicosa Bauermann

and

Mayara Maggioli

submission deadline 30 Apr 2025 | 8 articles | Viewed by 17043 | Submission Open

(This special issue belongs to the Section Animal Viruses)

Emerging Zoonotic Paramyxoviruses

edited by

Glenn Marsh

and

Jennifer Barr

submission deadline 30 Apr 2025 | 3 articles | Viewed by 5200 | Submission Open

Keywords: paramyxovirus; zoonotic; bat

(This special issue belongs to the Section Animal Viruses)

PANoptosis in Viral Infection

edited by

Thirumala-Devi Kanneganti

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4419 | Submission Open

Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome

(This special issue belongs to the Section General Virology)

Iridoviruses, 2nd Edition

edited by

Jian Zhang

and

Thomas B. Waltzek

submission deadline 30 Apr 2025 | 5 articles | Viewed by 4315 | Submission Open

Keywords: iridovirus; viral immune evasion; anti-viral immune responses; viral vaccine; viral pathogenesis; viral epidemiology

(This special issue belongs to the Section Animal Viruses)

Molecular and Cellular Biology of Human Oncogenic Viruses

edited by

Roberta Gonnella

submission deadline 30 Apr 2025 | 3 articles | Viewed by 3952 | Submission Open

Keywords: oncoviruses; antiviral drugs; viral oncogenesis; viral infection; oncogenic pathways; epigenetics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses

edited by Sasan Fereidouni

submission deadline 30 Apr 2025 | 3 articles | Viewed by 3575 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Hepatitis B Core-Related Antigen

edited by

Kuancheng Liu

submission deadline 30 Apr 2025 | 2 articles | Viewed by 3134 | Submission Open

Keywords: hepatitis B virus; core-related antigen; HBcrAg; HBc; HBeAg; PreC; biomarker; cccDNA activity; pathogenesis; disease progression

(This special issue belongs to the Section Human Virology and Viral Diseases)

Intra-patient Viral Evolution

edited by Adam A. Capoferri and

Mary Kearney

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2308 | Submission Open

Keywords: intra-patient viral evolution; drug resistance; immune escape; co-evolution; virus persistence; virus evolution

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2025 | 2 articles | Viewed by 2059 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options

edited by

Bluma G. Brenner

submission deadline 30 Apr 2025 | 2 articles | Viewed by 1896 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Nanovaccines against Viral Infection

edited by

Linzhu Ren

, Jing Qian and

Fuxian Zhang

submission deadline 30 Apr 2025 | 1 articles | Viewed by 586 | Submission Open

Keywords: nanoparticle; nanoantibody; nanovaccine; peptide-based nanovaccine; adjuvant and nanoadjuvant; antigen; nanotechnology in virus research

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 30 Apr 2025 | Viewed by 161 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Oncogenes

edited by

Francesca Caccuri

Antonella Bugatti

and Alberto Zani

submission deadline 30 Apr 2025 | Viewed by 147 | Submission Open

Keywords: oncogenic viruses; viral oncogenesis; human oncoviruses; virus–host interactions; antiviral agents; anticancer strategies

(This special issue belongs to the Section General Virology)

Advancements in Immunotherapy for Human Papillomavirus

edited by Katharine A. Price

submission deadline 30 Apr 2025 | Viewed by 115 | Submission Open

Keywords: human papillomavirus; cancer screening; vaccination; treatment; head-and-neck cancer; oropharyngeal cancer

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Phage Cocktails: Promising Approaches against Infections

edited by Jin Woo Jun

submission deadline 30 Apr 2025 | Viewed by 95 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Modeling the Unholy Trinity of Pandemics: Viral Infection, Immunity, and Virus Transmission 2025

edited by

Esteban A. Hernandez-Vargas

submission deadline 30 Apr 2025 | Viewed by 93 | Submission Open

Keywords: mathematical modeling; within-hosts dynamics; virus transmission; immune factors; pharmaceutical interventions (e.g.; vaccination; antiviral); viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 30 Apr 2025 | Viewed by 91 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 30 Apr 2025 | Viewed by 59 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 30 Apr 2025 | Viewed by 52 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Apr 2025 | Viewed by 32 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 30 Apr 2025 | Viewed by 18 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Coxsackieviruses, Polioviruses and Associated Diseases (Second Edition)

edited by

Yong Zhang

and

Didier Hober

submission deadline 1 May 2025 | 2 articles | Viewed by 1563 | Submission Open

Keywords: coxsackievirus; HFMD; viral Meningitis; myocarditis; pericarditis; herpangina; poliovirus; poliomyelitis; acute flaccid paralysis; post-polio syndrome; pleurodynia (Bornholm disease)

(This special issue belongs to the Section Human Virology and Viral Diseases)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 25 May 2025 | Viewed by 77 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Influenza, SARS-CoV-2, RSV and Other Vaccines: Immunogenicity Parameters and Protection, 3rd Edition

edited by

Zoltan Vajo

submission deadline 30 May 2025 | 5 articles | Viewed by 6609 | Submission Open

Keywords: SARS-CoV-2; serology; cellular immune response; protection; vaccines; influenza; Respiratory Syncytial Virus (RSV)

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 30 May 2025 | Viewed by 263 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 30 May 2025 | Viewed by 121 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Influenza B Virus: From Infection to Prevention

edited by Saira Hussain

submission deadline 30 May 2025 | Viewed by 69 | Submission Open

Keywords: influenza B viruses; epidemiology; evolution; pathogenesis; immunity; vaccine; antivirals

(This special issue belongs to the Section Animal Viruses)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 May 2025 | 5 articles | Viewed by 8613 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Functional and Structural Features of Viral RNA Elements

edited by

Stefan Weger

submission deadline 31 May 2025 | 4 articles | Viewed by 7200 | Submission Open

Keywords: RNA viruses; IRES elements; cap-independent protein synthesis; translation initiation; conserved RNA motifs

(This special issue belongs to the Section General Virology)

Avian Respiratory Viruses, Volume IV

edited by

Faizal Careem

submission deadline 31 May 2025 | 2 articles | Viewed by 3828 | Submission Open

Keywords: avian influenza virus; newcastle disease virus; infectious bronchitis virus; infectious laryngotracheitis; virus evolution; pathogenesis; virus– host interaction; vaccine; innate immune response; adjuvant; avian

(This special issue belongs to the Section Animal Viruses)

TMPRSS2 in Influenza Virus and Coronavirus Infections

edited by

Judy Wai Ping Yam

and Sze Keong Tey

submission deadline 31 May 2025 | 2 articles | Viewed by 2957 | Submission Open

Keywords: TMPRSS2; influenza virus; coronavirus; viral infection; treatment of viral diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Recombination

edited by

Alexandre Hassanin

submission deadline 31 May 2025 | 1 articles | Viewed by 1226 | Submission Open

Keywords: RNA viruses; DNA viruses; inter-genomic recombination; recombination rates; virus diversity; host ranges; methods of detection; models of recombination

(This special issue belongs to the Section General Virology)

Novel Insights into Porcine Viral Diseases: Recombinant Strains and Immune Responses

edited by

Kegong Tian

and

Xiangdong Li

submission deadline 31 May 2025 | Viewed by 108 | Submission Open

Keywords: porcine viral diseases; epidemiology; pathogenesis; recombination; immune responses

(This special issue belongs to the Section Animal Viruses)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 May 2025 | Viewed by 103 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 31 May 2025 | Viewed by 61 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Severe Fever with Thrombocytopenia Syndrome Virus 2025

edited by

Masayuki Saijo

submission deadline 31 May 2025 | Viewed by 47 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Oropouche Virus (OROV): An Emerging Peribunyavirus (Bunyavirus)

edited by

David A. Schwartz

and

André Ricardo Ribas Freitas

submission deadline 1 Jun 2025 | 2 articles | Viewed by 3803 | Submission Open

Keywords: oropouche fever; oropouche virus; bunyavirus; epidemic; travel infection; pregnancy complications; stillbirth; microcephaly; brazil; Latin America; emerging virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Recent Advances on Arboviruses Pathogenesis and Evolution

edited by Mariana Sequetin Cunha

submission deadline 17 Jun 2025 | Viewed by 103 | Submission Open

Keywords: virus outbreaks; phylogeny; virus evolution; pathology

(This special issue belongs to the Section Invertebrate Viruses)

Vertical Transmission of Human Papillomavirus Infections

edited by

Stina Syrjänen

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6334 | Submission Open

(This special issue belongs to the Section Animal Viruses)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4696 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

Plant Virus Spillovers

edited by

Steve Wylie

and

Nuredin Habili

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2584 | Submission Open

Keywords: spillover; emergence; replication; wild-plant virus; transmission; virus-cell interaction; vector

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Virus-Insect Interactions 2nd Edition

edited by Li-Long Pan

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1423 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 30 Jun 2025 | Viewed by 144 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Immune Responses to Papillomavirus Infections: 2nd Edition

edited by

Jiafen Hu

submission deadline 30 Jun 2025 | Viewed by 122 | Submission Open

Keywords: papillomavirus; HPV; immune responses; infections; models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infection and Platelets’ Disorders

edited by

Pierpaolo Di Micco

Alessandro Perrella

and

Giuseppe Camporese

submission deadline 30 Jun 2025 | Viewed by 23 | Submission Open

Keywords: viral infections; thrombosis; thrombotic microangiopathies; disseminated intravascular coagulation; low molecular weight heparin; bleedings; acute infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Glycans in Virus-Host Interactions

edited by Rahul Raman

submission deadline 15 Jul 2025 | 3 articles | Viewed by 9828 | Submission Open

Keywords: glycoeptiope; glycan receptors; viruses; antibodies; lectins

(This special issue belongs to the Section Animal Viruses)

Flow Virometry: A New Tool for Studying Viruses

edited by John Yin

submission deadline 15 Jul 2025 | 3 articles | Viewed by 4647 | Submission Open

Keywords: flow virometry; virus particle detection; virus counting; virus labeling/staining; virus-like particles; scanning ion occlusion sensing

(This special issue belongs to the Section General Virology)

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