Sci, Volume 7, Issue 1 (March 2025) – 13 articles

This study investigates the viability of incorporating bicycles into the Dhaka Metro system, a groundbreaking urban transit project for Bangladesh. As Dhaka’s inaugural metro rail network, the system signifies a substantial advancement in addressing urban congestion and enhancing transportation alternatives in one of the world’s most densely populated cities. The current design of the metro fails to accommodate bicycles, hindering efficient first- and last-mile connectivity. The investigation utilized data from 382 fully completed questionnaires, obtained through purposive sampling, about metro–cycle integration in Dhaka. The research employed RIDIT and TOPSIS analyses to rank the characteristics deemed most essential for bicycle–metro integration according to user opinions. Research indicates that secure bicycle parking, multi-modal ticketing, route comfort, and safety measures are the foremost objectives for commuters. The high emphasis on secure parking indicates the need for safe and accessible storage options that would make cycling a viable mode for reaching metro stations. A multi-modal ticketing system further enhances convenience, providing seamless transitions between transit modes. Journey comfort and the need to mitigate risks posed by motorized vehicles underscore the importance of safe and user-friendly commuting environments. While features like road and station design were ranked lower in priority, the study emphasizes that a well-integrated bicycle infrastructure is essential to ensure the metro system’s success. With these improvements, Dhaka’s metro system can meet the growing demands for sustainable and inclusive urban mobility, setting a precedent for future infrastructure projects in Bangladesh. Full article

Tocilizumab (TCZ) has demonstrated potential efficacy in managing large-vessel (LV) vasculitis such as giant-cell arteritis (GCA) and Takayasu arteritis (TAK). Despite the shared characteristics between the LV-GCA phenotype and TAK, there are differences between both entities that may affect therapeutic responses to TCZ. We aim to assess and compare the effectiveness and safety of TCZ in patients with LV-GCA and TAK. Multicenter, observational study on 70 LV-GCA patients and 57 TAK patients treated with TCZ. Outcomes were assessed at baseline and at 1, 3, 6 and 12 months post-treatment initiation. The variables analyzed included the following: (a) the achievement of clinical remission and improvement in laboratory markers; (b) imaging-based disease activity; (c) a glucocorticoid (GC)-sparing effect; and (d) side events and a safety profile. At the treatment initiation, TAK patients were younger, exhibited longer disease duration, had received more prior biologics, and were on higher doses of prednisone compared to LV-GCA patients. While TAK patients showed a slower initial clinical response, remission rates at 12 months were comparable between groups (74.5% for LV-GCA vs. 76.9% for TAK). Both groups experienced rapid laboratory marker improvement and a significant GC-sparing effect. However, complete imaging resolution was observed in only 18.9% of LV-GCA patients and 21.1% of TAK patients. The safety profile was similar in both groups, with severe infections leading to TCZ discontinuation in four LV-GCA and three TAK patients. In clinical practice, TCZ demonstrates similar efficacy in promoting remission and reducing GC dependency in both LV-GCA and TAK patients. Nonetheless, discrepancies between clinical outcomes and imaging improvement highlight the need for further investigation into disease monitoring and management strategies. Full article

Type 2 diabetes mellitus (T2DM) has a negative impact on the quality of life (QoL) of patients. We evaluated the health status and quality of life (QoL) in relation to accessibility to primary health care (PHC) units among patients with T2DM in mountainous Greece. We analyzed data obtained from 340 patients with diabetes living in the region of Epirus, Greece. The diabetes-specific quality of life was assessed with the Audit of Diabetes-Dependent Quality of Life questionnaire (ADDQoL-19) and the generic health status with the 12-item Short-Form Health Survey (SF-12). Ninety-three percent of the respondents reported that diabetes had a negative impact on their QoL. Lower scores were seen in relation to “leisure activities” (−1.200 ± 1.251) and “freedom to eat” (−1.088 ± 1.058). The mean physical (PCS) and mental (MCS) component scores were 45.6 ± 8.0 and 43.9 ± 8.0, respectively. According to the linear regression analysis, health status was related to the accessibility to the nearest hospital or health care unit, exercise, blood glucose level, and HbA1c level. The QoL was related to the accessibility to the nearest hospital and diet. T2DM has a negative impact on patients’ QoL. Accessibility to PHC units and hospitals as well as the efficient management of patients with diabetes by said PHC units are imperative to control T2DM’s course and improve patients’ generic health status. Full article

Skin Conductance Response (SCR) is a physiological index associated with arousing emotions. Previous studies have not explored the relationship between SCR signals and emotions in situations where multiple emotions dynamically fluctuate. Moreover, methods suitable for analyzing such conditions have not yet been established. In this study, we recorded the temporal changes in multiple emotions as subjectively reported by participants using the Temporal Dominance of Emotions (TDE) method. We then matched these subjective reports with the evolving SCR signals through regression analysis. This approach reveals which emotions contribute to increased SCR signals in prolonged, emotionally charged scenarios, such as watching videos or playing video games. To validate our method, we recorded SCR signals while participants played a video game. Participants then performed the TDE task to recall their emotions while viewing recorded footage. This study involved 20 participants. Our analysis showed that emotions such as excitement, tension, and frustration significantly covaried with the physiological signals. These arousing emotions are known to evoke SCR, supporting the validity of our method. This approach introduces a novel experimental methodology for comparing subjective reports and high-responsive physiology signals in settings where multiple emotions dynamically change. Full article

Depression and chronic pain are prevalent and often co-occurring conditions that pose substantial treatment challenges and economic burdens in the developed world. Research suggests that depression and chronic pain share overlapping pathways, particularly within the anterior cingulate cortex, which plays a critical role in emotional regulation and pain perception. Research indicates that exercise may alleviate depression. Given the shared neurobiology between depression and chronic pain, it is plausible that exercise could improve outcomes for individuals experiencing depression and chronic pain. Therefore, this review aims to provide clinicians with evidence-based tools to assess the role of exercise in the management of patients with coexistent pain and depression. Full article

Accurate surface area data are imperative for the development of meaningful property–function relationships. Nitrogen gas (N₂) adsorption/Brunauer–Emmet–Teller (BET) surface area analysis is a widely used technique for surface area characterization of materials because of straightforward sample preparation, automation, and low cost. However, iron disulfide (FeS₂) does not typically exhibit quantifiable N₂ monolayer formation in BET measurements. FeS₂ has been applied in fields such as batteries, catalysis, and adsorption, all of which would benefit from techniques that reliably assess surface area (SSA) of the active material. To address this, we evaluated FeS₂ samples by combining alternative surface characterization techniques to quantify SSA. Ten different FeS₂ samples from various manufacturers are characterized via BET, laser diffraction, scanning electron microscopy, non-contact profilometry, and liquid dye adsorption. Compared to BET, which resulted in a wide range of SSAs between 0.049–1.213 m² g⁻¹, liquid dye adsorption was found to be accurate for pyrite samples at low sample masses (<50 mg), with SSA values between 0.99–10.20 m² g⁻¹. Using an optical characterization approach, which combined particle size and surface roughness data, we readily estimated SSA of the particles and found these values correlated linearly with liquid adsorption but not BET values. This work serves to help researchers choose a more fitting method for examining low surface area materials like FeS₂ and can easily be applied to other minerals for quantitative and qualitative surface area comparisons. Full article

The inherent challenges of financial time series forecasting demand advanced modeling techniques for reliable predictions. Effective financial time series forecasting is crucial for financial risk management and the formulation of investment decisions. The accurate prediction of stock prices is a subject of study in the domains of investing and national policy. This problem appears to be challenging due to the presence of multi-noise, nonlinearity, volatility, and the chaotic nature of stocks. This paper proposes a novel financial time series forecasting model based on the deep learning ensemble model LSTM-mTrans-MLP, which integrates the long short-term memory (LSTM) network, a modified Transformer network, and a multilayered perception (MLP). By integrating LSTM, the modified Transformer, and the MLP, the suggested model demonstrates exceptional performance in terms of forecasting capabilities, robustness, and enhanced sensitivity. Extensive experiments are conducted on multiple financial datasets, such as Bitcoin, the Shanghai Composite Index, China Unicom, CSI 300, Google, and the Amazon Stock Market. The experimental results verify the effectiveness and robustness of the proposed LSTM-mTrans-MLP network model compared with the benchmark and SOTA models, providing important inferences for investors and decision-makers. Full article

This study aims to contribute to the physical understanding of the behavior of nanoparticles in lipid–nanoparticle composite systems. Therefore, composite films were formed on hydrophilic or hydrophobic surfaces through the sequential adsorption of liposomes and silica nanoparticles. The process was performed using dispersions with different pHs by using optical fixed-angle reflectometry. In the first step, liposomes were deposited on the surface, resulting in a lipid monolayer or bilayer depending on the surface’s properties. The kinetic experiments indicated that the adsorption of liposomes is a diffusion-limited process that depends on the pH and the properties of the substrate. In the second step, negatively charged nanoparticles were adsorbed on the membrane as a result of the electrostatic interactions with the positively charged domains on the membrane. The amounts of liposomes and particles adsorbed depend on the charge density of the particles and net charge density of the membrane: an increase in the pH and hydrophobicity of the surface leads to a decrease in the amounts adsorbed because of the increase in the electrostatic repulsion between particles and lipids. The procedure was supplemented with the formation of two liposomes/nanoparticles bilayers. Full article

This paper discusses the combined application of the Acoustic Emission (AE) technique and a Lattice Discrete Element Method (LDEM) to study the damage process in cement mortar specimens subjected to three-point bending tests. The experimental work was carried out in a previous study by the research team. The specimens contain macro-capsules filled with a polyurethane resin that promotes a self-healing mechanism upon crack formation. The numerical model here developed provides an estimate of the fracture energy of the resin, which is difficult to obtain by relying purely on experimental results. Furthermore, this study includes the analysis of both fracture energy and Acoustic Emission energy based on experimental tests using the same specimens. Through the comparison of experimental and numerical results, a correlation between the toughness of the specimens and AE activity is established. The findings indicate that, for the self-healing specimens, there is a decrease in fracture energy as the emitted Acoustic Emission (AE) energy increases. Full article

A study of the antifriction properties of suspension solid-lubricating coatings based on molybdenum disulfide (MoS₂) at high temperatures depending on the type of substrate, binder, additives, and load parameters was carried out. The solid lubricants were sprayed on two different substrates, high-temperature alloy (Inconel X-750) and stainless steel (AISI 430), tested under 10 N and 23 N loads at temperatures ranging from 25 °C to 800 °C. For comparison, different types of solid lubricants were used. In this work, it was established that the antifriction properties of solid lubricant suspension coatings at high temperatures significantly depend on the type of solid lubricant and the binder used. Moreover, it was shown that the use of Inconel X-750 as a substrate can lead to an increase in the critical operating temperature of coatings containing MoS₂, graphite, and titanate as solid lubricant, additive, and binder, respectively. For instance, at load 23 N, the operating temperature increased from 480 °C to 496 °C. On the other hand, the coating based on graphite, containing ceramic as an additive, and an inorganic binder showed the best performance in terms of a combination of properties (low coefficient of friction and longer operation with a coefficient of friction below 0.3 under increasing temperature) when it was applied on the Inconel X-750 substrate. In addition, it was established that the coefficient of friction of graphite-based coatings gradually increases as they lose their antifriction properties due to their failure, while the coatings based on molybdenum disulfide show the opposite behavior, where the coefficient of friction increases sharply when it loses its lubricating properties. Full article

The conversion of betulinic acid (BA) to organic salts is a strategic approach to modulate its physicochemical properties and biological activity. In our previous study, we demonstrated the enhanced cytotoxicity of certain amino acid ethyl ester betulinates ([AAOEt][BA]) compared to BA against hormone-dependent breast cancer cells (MCF-7). In this study, we extended our investigation to evaluate the cytotoxic response and thermodynamic properties of hormone-independent breast cancer cells (MDA-MB-231) following 72 h of treatment with the same series of betulinates. Our data reveal a lower cytotoxic response in MDA-MB-231 cells, indicated by higher half-maximal inhibitory concentration (IC₅₀) values, which ranged between 31 and 109 μM. Differential scanning calorimetry analysis supported these findings, showing negligible changes in the thermodynamic parameters of the treated MDA-MB-231 cells. However, consistent with our previous observations, [LysOEt][BA]₂, exhibited the highest cytotoxicity and induced the most pronounced morphological alterations in the cancer cells. Overall, our results suggest that MDA-MB-231 cells are less sensitive to [AAOEt][BA] compared to MCF-7 cells, likely due to their distinct phenotypic and genotypic profiles and differences in oncogenic signalling pathways. Nonetheless, the fact that [LysOEt][BA]₂ enhances the cytotoxic activity of BA even in hormone-independent breast cancer cells underscores its therapeutic potential and warrants further investigation, particularly in the context of adjuvant breast cancer therapy. Full article

The multielement pyrochlore of the composition Bi_1.57Mn_1/3Cr_1/3Cu_1/3Nb₂O_9−Δ (sp. gr. Fd-3m:2, 10.4724 Å) containing transition element atoms—chromium, manganese and copper in equimolar amounts—was synthesized for the first time using the solid-phase reaction method. The microstructure of the ceramics is grainless and has low porosity. The sample is characterized by reflection in the red (705 nm) color region. The band gap for the direct allowed transition in the sample is 1.68 eV. The parameters of the Bi5d, Nb3d, Сr2p, Mn2p, and Cu2p X-ray photoelectron spectroscopy (XPS) spectra for the mixed pyrochlore are compared with the parameters of transition element oxides. For the complex pyrochlore, a characteristic shift in the Bi4f and Nb3d spectra to the region of lower energies by 0.15 and 0.60 eV, respectively, is observed. According to the XPS Cu2p and Mn2p spectra of pyrochlore, copper, and manganese cations are in a mixed charge state; they mainly have an effective charge of +2/+3, and the Cr2p spectrum is a superposition of the spectra of chromium ions in the charge state of +3, +4, +6. At 24 °С, the permittivity of the sample in the frequency range (10⁴–10⁶ Hz) weakly depends on the frequency and is equal to ~100, the dielectric loss tangent is 0.017. The activation energy of conductivity is equal to 0.41 eV. The specific electrical conductivity of Bi_1.57Cr_1/3Cu_1/3Mn_1/3Nb₂O_9−Δ increases with the temperature increasing from 1.8 × 10⁻⁵ Ohm⁻¹·m⁻¹ (24 °С) to 0.1 Ohm⁻¹·m⁻¹ (330 °С). Nyquist curves for the sample are modeled by equivalent electrical circuits. Full article