Oxidative Stress in Pregnancy and Childhood

Dear Colleagues,

A second volume of ‘Oxidative Stress during Pregnancy and Childhood’ is being proposed in order to offer neonatologists and pediatricians with a modern and complete view of the various problems and aspects of oxidative stress in neonatology, currently among the most complex and advanced fields of pediatrics.

The volume will be dedicated to the epidemiology of neonatal mortality and morbidity and to the conditions responsible for oxidative stress prenatal and neonatal risk. A section will be devoted to new antioxidant drugs and strategies for efficient modern neonatal and infant care.

Particular attention will be paid to brain-oriented care and current availability of laboratory facilities and instrumentation for the early identification of perinatal abnormalities. Conditions jeopardizing oxidative stress and fetal health such as diabetes, maternal drug abuse and smoking will be discussed.

Moreover, the concept of fetal programming, relating the origins of adult diseases to an altered redox environment, has been established, with evidence in this field now extensively.  

Oxidative stress plays a role in generating and favoring structural placental alterations that may cause adverse neonatal outcomes. For this purpose, the cellular and molecular mediators associated with complications of pregnancy will be examined as these are essential for the development of successful intervention and prevention strategies. Different oxidative stress-related diseases of the neonate, involving lungs, heart, gastrointestinal tract, blood, immune system, endocrine system, and kidneys, will be expounded up. Fetal and neonatal infections and neurological abnormalities will also be discussed in depth.

Also, the neurodevelopmental alterations that may be found in children who have experienced any form of oxidative stress during the fetal and postnatal period will be discussed and examined.

The next challenging goal will be to define as-yet-unrecognized biologic therapeutic targets and link oxidative stress biomarkers to relevant standard indices and long-term outcomes.

We invite authors to submit the latest research results or review articles to this Issue, which will bring together current research related to oxidative stress in pregnancy and childhood and discuss the effects of antioxidant therapy.

Readers will be able to use this volume alongside the summaries, tables, and accurately selected guidelines or recommendations accompanying it to supply quick references and instant solutions to the concerned neonatologists and pediatricians during their daily practice.

Prof. Dr. Giuseppe Buonocore
Prof. Dr. Eloisa Gitto
Prof. Dr. Serafina Perrone
Guest Editors

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• oxidative stress
• neonatology
• pediatrics