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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Oxidative Stress in Ovarian Cancer

edited by

Subramanyam Dasari

and

Venkatesh Pooladanda

submission deadline 31 Dec 2024 | Viewed by 335 | Submission Open

Keywords: ovarian cancer; reactive oxygen species (ROS); metastasis; antioxidant; oxidative stress; chemotherapeutic resistance; inflammation

(This special issue belongs to the Section Molecular Medicine)

The Role of Non-coding RNAs in Health and Disease

edited by

Narasimman Gurusamy

submission deadline 31 Dec 2024 | Viewed by 335 | Submission Open

Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

Molecular and Biochemical Mechanisms of Age-Related Macular Degeneration, Neuroophthalmological Diseases and Uveitis

edited by

Puran S. Bora

submission deadline 31 Dec 2024 | Viewed by 328 | Submission Open

Keywords: retina; neovascularization; age-related macular degeneration; uveal tissue; neuro-ocular diseases

(This special issue belongs to the Section Molecular Medicine)

The Endoplasmic Reticulum Stress in Yeast and Fungal Cells

edited by

Yukio Kimata

submission deadline 31 Dec 2024 | Viewed by 321 | Submission Open

Keywords: unfolded protein response; yeast; fungi; endoplasmic reticulum; protein production

(This special issue belongs to the Section Molecular Biology)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants 2.0

edited by

Marina Piscopo

submission deadline 31 Dec 2024 | Viewed by 316 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 31 Dec 2024 | Viewed by 315 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Adduct Science

edited by Yukari Totsuka and Haruhiko Sugimura

submission deadline 31 Dec 2024 | Viewed by 306 | Submission Open

Keywords: adductomics; protein- or nucleic acid-adducts; biomarkers; exposome; genomic mutations; disease etiology; preventive strategies; drug discovery; risk assessment

The Role of MDM2 in Tumor Biology and Cancer Therapy

edited by

Ruiwen Zhang

and

John Buolamwini

submission deadline 31 Dec 2024 | Viewed by 295 | Submission Open

Keywords: MDM2; p53; targeted therapy; imunotherapy; drug resistance

(This special issue belongs to the Section Molecular Genetics)

Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities

edited by

Natalia Osna

and

Kusum K. Kharbanda

submission deadline 31 Dec 2024 | Viewed by 292 | Submission Open

Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD

(This special issue belongs to the Section Molecular Medicine)

Applications of NMR Spectroscopy in Structure-Based Drug Discovery

edited by Alexander L. Breeze and Reto Walser

submission deadline 31 Dec 2024 | Viewed by 279 | Submission Open

Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation

(This special issue belongs to the Section Molecular Structure and Dynamics)

Regeneration of Annelids: From Reorganization of Lost Body Parts to Cellular and Molecular Biological Background

edited by

László Molnár

submission deadline 31 Dec 2024 | Viewed by 272 | Submission Open

Keywords: regeneration; body plan; dedifferentiation; stem cells; morphallaxis; epimorphosis; neuro-immune interactions

(This special issue belongs to the Section Cellular Biochemistry)

Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition

edited by

Bahman Anvari

submission deadline 31 Dec 2024 | Viewed by 255 | Submission Open

Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics

Role of Glutathione Peroxidase in Health and Disease

edited by R Steve Esworthy

submission deadline 31 Dec 2024 | Viewed by 242 | Submission Open

Keywords: GPX1; GPX2; GPX3; GPX4; GPX5; GPX6; GPX7; GPX8; selenium; cancer; pathology

(This special issue belongs to the Section Molecular Medicine)

Combination Therapies Involving MicroRNA Modulation: Synergistic Approaches for Enhanced Anticancer Effects

edited by

Joanna Szczepanek

and

Andrzej Tretyn

submission deadline 31 Dec 2024 | Viewed by 238 | Submission Open

Keywords: microRNA (miRNA); targeted therapy; cancer

Biomolecules from Natural Products: Anti-inflammatory and Anti-allergic Activities: 2nd Edition

edited by

Chi-Feng Hung

submission deadline 31 Dec 2024 | Viewed by 228 | Submission Open

Keywords: anti-inflammation; anti-allergic; natural product; anti-aging

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Peptide and Metabolite Self-Assembly: Physiology, Pathology, Biomaterials and Their Biomedical Applications

edited by

Kuo Zhang

and

Annarita Falanga

submission deadline 31 Dec 2024 | Viewed by 227 | Submission Open

Keywords: peptide and metabolite; self-assembly; physiology and pathology; biomaterials; biomedicine

(This special issue belongs to the Section Molecular Structure and Dynamics)

Tumour Suppressor Genes: The Guardians of Cell Integrity

edited by

Nicola Manfrini

submission deadline 31 Dec 2024 | Viewed by 222 | Submission Open

Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy

(This special issue belongs to the Section Molecular Biology)

Protein Misfolding Diseases: Molecular Mechanisms and Therapeutic Strategies

edited by Priyanka Joshi and Michele Perni

submission deadline 31 Dec 2024 | Viewed by 200 | Submission Open

Keywords: protein aggregation; protein misfolding; biomolecular condensation; chemical kinetics; cellular homeostasis; small molecules; antibody therapeutics; drug discovery; neurodegeneration; neurodegenerative diseases

(This special issue belongs to the Section Molecular Structure and Dynamics)

Elucidating the Roles of Chromatin in Genomic Processes

edited by

Daniel M. Czajkowsky

and Meijun Liu

submission deadline 31 Dec 2024 | Viewed by 161 | Submission Open

Keywords: nucleosome positioning and occupancy; histone modifications; histone variants; nucleosome chaperones; nucleosome remodelers; insulator proteins; CTCF and cohesin; cis-regulatory elements; 3D genome structure; chromatin dynamics

Molecular Mechanisms in New Strategies for Longevity

edited by

Yoshinari Uehara

submission deadline 31 Dec 2024 | Viewed by 160 | Submission Open

Keywords: longevity; atherosclerosis; lipids; exercise; foods

Prebiotics and Probiotics in Health and Disease: Looking at the Future

edited by

Pio Maria Furneri

Virginia Fuochi

and

Giovanna Furneri

submission deadline 7 Jan 2025 | 1 articles | Viewed by 1779 | Submission Open

Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics

(This special issue belongs to the Section Molecular Medicine)

Zinc in Health and Disease Conditions: 2nd Edition

edited by

Xiang-Ping Chu

submission deadline 10 Jan 2025 | 5 articles | Viewed by 8713 | Submission Open

Keywords: zinc; physiology; disease; regulation/modulation; function; pathology

(This special issue belongs to the Section Molecular Medicine)

Biosynthesis and Function of Thyroid Hormones

edited by

Josef Koehrle

and Eva K. Wirth

submission deadline 10 Jan 2025 | 1 articles | Viewed by 824 | Submission Open

Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements

(This special issue belongs to the Section Biological Factors)

Extracellular Vesicles as Biomarkers of Diseases

edited by

Mebarek Saida

and

Leyre Brizuela

submission deadline 15 Jan 2025 | 7 articles | Viewed by 11365 | Submission Open

Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

The Value of Natural Compounds as Therapeutic Agents: 2nd Edition

edited by

Maria Beatrice Morelli

submission deadline 15 Jan 2025 | 4 articles | Viewed by 8221 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms of Human Skin Aging

edited by

Taihao Quan

submission deadline 15 Jan 2025 | 3 articles | Viewed by 5843 | Submission Open

Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention

(This special issue belongs to the Section Molecular Medicine)

Learn from Machine Learning: The Identification of Biomarkers and Therapeutic Targets in Neurodegeneration

edited by

Haibo Wang

and

Chen Huang

submission deadline 15 Jan 2025 | 2 articles | Viewed by 4611 | Submission Open

Keywords: machine learning; neurodegeneration; biomarkers; therapeutic targets; data mining

(This special issue belongs to the Section Molecular Medicine)

Circular RNAs: Functions, Applications and Prospects: 2nd Edition

edited by

William W. Du

and Feiya Li

submission deadline 15 Jan 2025 | 2 articles | Viewed by 3934 | Submission Open

Keywords: circular RNAs; circRNA; function; application; disease

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 15 Jan 2025 | Viewed by 215 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

Sterol Biosynthesis and Function in Organisms

edited by Hubert Schaller

submission deadline 20 Jan 2025 | 6 articles | Viewed by 7702 | Submission Open

Keywords: sterol; biosynthesis; function; organisms

(This special issue belongs to the Section Molecular Biology)

Physiological and Pathological Functions of Crystallins

edited by

Roy Quinlan

and John Clark

submission deadline 20 Jan 2025 | 1 articles | Viewed by 2581 | Submission Open

Keywords: crystallin; small heat shock protein chaperone; transparency; phase separation; aging; age related disease; cataract; cancer; schizophrenia; fertility

(This special issue belongs to the Section Biomacromolecules: Proteins)

Immune Responses in Type 1 Diabetes

edited by

Eddie A. James

and Sally C. Kent

submission deadline 20 Jan 2025 | Viewed by 539 | Submission Open

Keywords: type 1 diabetes; insulitis; immune response

(This special issue belongs to the Section Molecular Biology)

Synaptogenesis, Synaptic Plasticity and Brain Disorders

edited by Rubén Deogracias

submission deadline 20 Jan 2025 | Viewed by 284 | Submission Open

Keywords: synaptic plasticity; neuron; brain disorders; brain damage

(This special issue belongs to the Section Molecular Biology)

Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques

edited by

Rohit Jain

, Corie Ralston and

Gang (Gary) Ren

submission deadline 20 Jan 2025 | Viewed by 179 | Submission Open

Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS

(This special issue belongs to the Section Bioinformatics and Systems Biology)

More than Just Adhesion: Recognition Molecules, a Theme Issue Honoring Professor Melitta Schachner

edited by

Igor Jakovcevski

submission deadline 25 Jan 2025 | 1 articles | Viewed by 2731 | Submission Open

Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development

(This special issue belongs to the Section Biological Factors)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Jan 2025 | 15 articles | Viewed by 37002 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Novel Materials for Biomedical Applications: 2nd Edition

edited by

Jayakumar Rajadas

and

Mustafeez Mujtaba Babar

submission deadline 31 Jan 2025 | 8 articles | Viewed by 19139 | Submission Open

Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering

(This special issue belongs to the Section Biological and Bio- Materials)

Recent Advances in Neurological Diseases

edited by Sara Carpi,

Antonio Leo

and

Ambra Del Grosso

submission deadline 31 Jan 2025 | 6 articles | Viewed by 10934 | Submission Open

Keywords: neurological disorders; neurodegeneration; neuroinflammation; myelin damage; developmental disorders; epilepsy; neurodegenerative rare diseases; neuromuscular diseases; lipid storage diseases; psychiatric diseases

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanisms of Endometriosis

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 31 Jan 2025 | 6 articles | Viewed by 9958 | Submission Open

Keywords: endocrine dysfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

The Structure and Function of Proteins, Lipids and Nucleic Acids

edited by

Ivo Crnolatac

submission deadline 31 Jan 2025 | 6 articles | Viewed by 9940 | Submission Open

(This special issue belongs to the Section Molecular Structure and Dynamics)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications

edited by

Michele Scuruchi

submission deadline 31 Jan 2025 | 4 articles | Viewed by 9781 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Carbohydrates)

NMDA Receptor in Health and Diseases: 2nd Edition

edited by

Motohiro Okada

submission deadline 31 Jan 2025 | 4 articles | Viewed by 7995 | Submission Open

(This special issue belongs to the Section Molecular Biology)

The Central Role of Mitochondrial Protein VDAC1 in Human Diseases – Honorary Special Issue Commemorating the Work of Prof. Varda Shoshan-Barmatz

edited by Jay H. Chung

submission deadline 31 Jan 2025 | 6 articles | Viewed by 7542 | Submission Open

Keywords: apoptosis; ferroptosis; inflammation; metabolism; mitochondria; oxidative stress; pyroptosis; VDAC; cancer

(This special issue belongs to the Section Cellular Biochemistry)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 31 Jan 2025 | 4 articles | Viewed by 7176 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Prostate Cancer Biomarkers and Therapeutics

edited by Kamlesh Kumar Yadav

submission deadline 31 Jan 2025 | 3 articles | Viewed by 6146 | Submission Open

Keywords: prostate cancer; biomarkers; therapeutics; chemotherapy; immunotherapy; radiation therapy; machine learning

(This special issue belongs to the Section Molecular Biomarkers)

The Role of Glia in Alzheimer's Disease

edited by

Sriram Balusu

submission deadline 31 Jan 2025 | 1 articles | Viewed by 5385 | Submission Open

Keywords: Alzheimer's disease; neurodegeneration; glial cells

(This special issue belongs to the Section Molecular Medicine)

Therapeutic Potential of Natural Products in Metabolic Diseases

edited by

Atanas G. Atanasov

Ronan Lordan

and

Ren-You Gan

submission deadline 31 Jan 2025 | 2 articles | Viewed by 4627 | Submission Open

Keywords: natural products; metabolic disorders; diabetes mellitus; dietary constituents; phytotherapy; integrative medicine; obesity; dyslipidemia; non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH); nutraceuticals; supplements

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Role of Microglia in Aging and Neurodegenerative Disease

edited by

Björn Spittau

submission deadline 31 Jan 2025 | 3 articles | Viewed by 4530 | Submission Open

Keywords: microglia; neurodegenerative diseases; disease-associated microglia (DAM); microglia activation; Alzheimer's disease; Parkinson’ s disease; ischemic stroke

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Jan 2025 | 3 articles | Viewed by 3891 | Submission Open

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Key Molecules in Traditional Medicine: From Molecular Mechanisms to Therapies Strategies

edited by