Microfluidic Systems for Single Cell Analysis
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 6174
Special Issue Editors
Interests: high throughput single cell genomic sequencing; biomicrofluidic chip; digital PCR; deep learning and artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Interests: microfluidics system and its application in life sciences; surface plasmon resonance biosensors; integrated nanobiotechnology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Up to now, microfluidic systems have dramatically facilitated the development of single-cell analysis by leveraging the micro-scale geometry for improving sensitivity, decreasing reaction time, decreasing reagents consumption, and improving parallelization and automation for high throughput. Microfluidic droplets offer extremely high scalability of reactions and straightforward single cell manipulation. Single-cell analysis techniques based on the microfluidics systems have become a powerful tool and a driving force for biological studies and discoveries. This growing field has increased the sensitivity, accuracy, and throughput of traditional single-cell analysis methods. Especially, single-cell sequencing methods based on microfluidics systems have enabled the rapid genome-wide analysis of thousands of single cells. These cutting-edge methods have allowed us to profile cells at unprecedented resolutions and numbers, thus building a complete human cell atlas. Such a comprehensive database would inform us of the fundamental features of each cell type and lead insights into the changes and underlying mechanisms behind biological regulatory mechanisms and evolutionary processes, as well as disease onset and progression. Microfluidic systems also contribute to human tumor atlases, and deciphering this complex issue involves a high degree of heterogeneity among different cell populations and their interactions.
For this Special Issue titled "Microfluidic Systems for Single-Cell Analysis", we welcome original works, perspectives, and reviews including but not limited to the developments and applications of single-cell analysis methods based on microfluidic systems, including single-cell capturing, sorting, culture, imaging, protein analysis, nucleic acid analysis, as well as genomics, transcriptomics, spatial transcriptomics, epigenomics, and multi-omics analyses.
Prof. Dr. Qiangyuan Zhu
Prof. Dr. Ying Mu
Guest Editors
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Keywords
- single-cell isolation
- capturing
- sorting
- culture
- imaging
- protein analysis
- nucleic acid analysis
- genomics analysis
- transcriptomics analysis
- spatial transcriptomics analysis
- epigenomics analysis
- multi-omics analysis
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