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Biosensors
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Nano-Biosensors for Detection and Monitoring (2nd Edition)
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Nano-Biosensors for Detection and Monitoring (2nd Edition)

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 8156

Special Issue Editor

Dr. Krishna Kant

E-Mail Website
Guest Editor
Centro De Investigaciones Biomédicas (CINBIO), Universidade de Vigo, 36310 Vigo, Spain
Interests: microfluidic sensing; electrochemical bio-sensing; point-of-care diagnostics; precision diagnostics; plasmonic sensing; microfluidic devices; lab-on-chip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sensing technology is a swiftly evolving field with major applications in biological substances and detection devices, including rapid detection for chemical, biological, and environmental monitoring. This Special Issue is devoted to advances in a diversity of topics in this area, from detection to engineering and incorporation methods to novel sensors. Articles reporting on the latest developments in multiplexed detection including electrochemical, optical, magnetic, and other transduction types are welcome.

I am delighted to welcome you to submit a paper to this Special Issue on “Nano-Biosensors for Detection and Monitoring”, which are evolving research subjects with a variety of applications. The scope of the Special Issue in the field of biosensing is wide, including, but not limited to, the following areas:

  • Advancement of biosensor methodologies and applications;
  • Invention technology of chip-based detection devices;
  • Biomimetic systems and devices for biosensing application;
  • Biological and chemical actuators, including smart materials and components;
  • Lab-on-a-chip systems.

Research articles and complete, thorough review reports on recent developments in the field, as well as accomplishments and new technologies claiming to be relevant to biosensing and actuation, will be considered for publication. This Special Issue is addressed at biologists, cell culture experts, etc.

Dr. Krishna Kant
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostics
  • molecular imprinted polymer biosensing
  • multiplexed biosensing
  • bio-inspired materials
  • cell and tissue sensors

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

12 pages, 2423 KiB  
Article
Gold–Graphene Quantum Dot Hybrid Nanoparticle for Smart Diagnostics of Prostate Cancer
by Divakar Raj, Arun Kumar, Dhruv Kumar, Krishna Kant and Ashish Mathur
Biosensors 2024, 14(11), 534; https://doi.org/10.3390/bios14110534 - 4 Nov 2024
Viewed by 1449
Abstract
Prostate cancer is one of the most prevalent cancers afflicting men worldwide, often detected at advanced stages, leading to increased mortality rates. Addressing this challenge, we present an innovative approach employing electrochemical biosensing for early-stage prostate cancer detection. This study used Indium–Tin Oxide [...] Read more.
Prostate cancer is one of the most prevalent cancers afflicting men worldwide, often detected at advanced stages, leading to increased mortality rates. Addressing this challenge, we present an innovative approach employing electrochemical biosensing for early-stage prostate cancer detection. This study used Indium–Tin Oxide (ITO) as a substrate and a deposited gold–graphene quantum dot (Au–GQD) nanohybrid to establish electrochemical sensing platforms for DNA-hybridization assays. A capturing DNA probe, PCA3, was covalently immobilized on the surface of the Au–GQDs and deposited electrochemically onto the ITO electrode surface. The Au–GQDs enabled the capturing of the target PCA3 biomarker probe. The sensor achieved a limit of detection (LoD) of up to 211 fM and presented a linear detection range spanning 1 µM to 100 fM. A rapid 5-min response time was also achieved. The tested shelf life of the pre-immobilized sensor was approximately 19 ± 1 days, with pronounced selectivity for its intended target amidst various interferants. The sensing device has the potential to revolutionize prostate cancer management by facilitating early-stage detection and screening with enhanced treatment efficacy. Full article
(This article belongs to the Special Issue Nano-Biosensors for Detection and Monitoring (2nd Edition))
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14 pages, 3754 KiB  
Article
Magnetic Immunoassay Based on Au Pt Bimetallic Nanoparticles/Carbon Nanotube Hybrids for Sensitive Detection of Tetracycline Antibiotics
by Jianxia Lv, Rui Huang, Kun Zeng and Zhen Zhang
Biosensors 2024, 14(7), 342; https://doi.org/10.3390/bios14070342 - 15 Jul 2024
Viewed by 1265
Abstract
Misusage of tetracycline (TC) antibiotics residue in animal food has posed a significant threat to human health. Therefore, there is an urgent need to develop highly sensitive and robust assays for detecting TC. In the current study, gold and platinum nanoparticles were deposited [...] Read more.
Misusage of tetracycline (TC) antibiotics residue in animal food has posed a significant threat to human health. Therefore, there is an urgent need to develop highly sensitive and robust assays for detecting TC. In the current study, gold and platinum nanoparticles were deposited on carbon nanotubes (CNTs) through the superposition method (Au@Pt/CNTs-s) and one-pot method (Au@Pt/CNTs-o). Au@Pt/CNTs-s displayed higher enzyme-like activity than Au@Pt/CNTs-o, which were utilized for the development of sensitive magnetic immunoassays. Under the optimized conditions, the limits of detection (LODs) of magnetic immunoassays assisted by Au@Pt/CNTs-s and Au@Pt/CNTs-o against TCs could reach 0.74 ng/mL and 1.74 ng/m, respectively, which were improved 6-fold and 2.5-fold in comparison with conventional magnetic immunoassay. In addition, the measurement of TC-family antibiotics was implemented by this assay, and ascribed to the antibody used that could recognize TC, oxytetracycline, chlortetracycline, and doxycycline with high cross-reactivity. Furthermore, the method showed good accuracy (recoveries, 92.1–114.5% for milk; 88.6–92.4% for pork samples), which also were applied for determination of the targets in real samples. This study provides novel insights into the rapid detection of targets based on high-performance nanocatalysts. Full article
(This article belongs to the Special Issue Nano-Biosensors for Detection and Monitoring (2nd Edition))
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11 pages, 5385 KiB  
Communication
A Novel Indolium-Based Fluorescent Probe for Fast Detection of Cyanide
by Mei Ding, Xiao Xiao, Chen Zhou, Mingxin Luo and Jing Sun
Biosensors 2024, 14(5), 244; https://doi.org/10.3390/bios14050244 - 13 May 2024
Viewed by 1352
Abstract
A novel indolium-based fluorescent probe for the detection of CN− was developed based on the conjugation of 1, 2, 3, 3-Tetramethyl-3H-indolium iodide and 2-acetyl benzothiophene. The introduction of external CN− caused a nucleophilic attack to the quaternary amine salt structure in [...] Read more.
A novel indolium-based fluorescent probe for the detection of CN− was developed based on the conjugation of 1, 2, 3, 3-Tetramethyl-3H-indolium iodide and 2-acetyl benzothiophene. The introduction of external CN− caused a nucleophilic attack to the quaternary amine salt structure in the probe and resulted in the departure of iodide ions and the steric rotation of the index salt group, which caused fluorescence quenching. The titration experiments showed that the probe had rapid qualitative and quantitative analysis capabilities for CN−. Moreover, the relevant biocompatibility experiments also demonstrated the potential application value of the probe. Full article
(This article belongs to the Special Issue Nano-Biosensors for Detection and Monitoring (2nd Edition))
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12 pages, 1601 KiB  
Article
Using Temporally and Spatially Resolved Measurements to Improve the Sensitivity of Fluorescence-Based Immunoassays
by Ran Kremer, Shira Roth, Avital Bross, Amos Danielli and Yair Noam
Biosensors 2024, 14(5), 220; https://doi.org/10.3390/bios14050220 - 28 Apr 2024
Viewed by 1724
Abstract
Detecting low concentrations of biomarkers is essential in clinical laboratories. To improve analytical sensitivity, especially in identifying fluorescently labeled molecules, typical optical detection systems, consisting of a photodetector or camera, utilize time-resolved measurements. Taking a different approach, magnetic modulation biosensing (MMB) is a [...] Read more.
Detecting low concentrations of biomarkers is essential in clinical laboratories. To improve analytical sensitivity, especially in identifying fluorescently labeled molecules, typical optical detection systems, consisting of a photodetector or camera, utilize time-resolved measurements. Taking a different approach, magnetic modulation biosensing (MMB) is a novel technology that combines fluorescently labeled probes and magnetic particles to create a sandwich assay with the target molecules. By concentrating the target molecules and then using time-resolved measurements, MMB provides the rapid and highly sensitive detection of various biomarkers. Here, we propose a novel signal-processing algorithm that enhances the detection and estimation of target molecules at low concentrations. By incorporating both temporally and spatially resolved measurements using human interleukin-8 as a target molecule, we show that the new algorithm provides a 2–4-fold improvement in the limit of detection and an ~25% gain in quantitative resolution. Full article
(This article belongs to the Special Issue Nano-Biosensors for Detection and Monitoring (2nd Edition))
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14 pages, 4361 KiB  
Article
Continuous In Vivo Monitoring of Indole-3-Acetic Acid and Salicylic Acid in Tomato Leaf Veins Based on an Electrochemical Microsensor
by Lingjuan Tang, Daodong Li, Wei Liu, Yafang Sun, Ying Dai, Wenjing Cui, Xinliu Geng, Dayong Li, Fengming Song and Lijun Sun
Biosensors 2023, 13(12), 1002; https://doi.org/10.3390/bios13121002 - 28 Nov 2023
Cited by 6 | Viewed by 1844
Abstract
Indole-3-acetic acid (IAA) and salicylic acid (SA), as critical plant hormones, are involved in multiple physiological regulatory processes of plants. Simultaneous and continuous in vivo detection of IAA and SA will help clarify the mechanisms of their regulation and crosstalk. First, this study [...] Read more.
Indole-3-acetic acid (IAA) and salicylic acid (SA), as critical plant hormones, are involved in multiple physiological regulatory processes of plants. Simultaneous and continuous in vivo detection of IAA and SA will help clarify the mechanisms of their regulation and crosstalk. First, this study reports the development and application of an electrochemical microsensor for simultaneous and continuous in vivo detection of IAA and SA. This electrochemical microsensor system consisted of a tip (length, 2 mm) of platinum wire (diameter, 0.1 mm) modified with carbon cement and multi-walled carbon nanotubes, an untreated tip (length, 2 mm) of platinum wire (diameter, 0.1 mm), as well as a tip (length, 2 mm) of Ag/AgCl wire (diameter, 0.1 mm). It was capable of detecting IAA in the level ranging from 0.1 to 30 µM and SA ranging from 0.1 to 50 µM based on the differential pulse voltammetry or amperometric i-t., respectively. The dynamics of IAA and SA levels in tomato leaf veins under high salinity stress were continuously detected in vivo, and very little damage occurred. Compared to conventional detection methods, the constructed microsensor is not only suitable for continuously detecting IAA and SA in microscopic plant tissue in vivo, it also reduces the damage done to plants during the detection. More importantly, the continuous and dynamic changes in IAA and SA data obtained in stiu through this system not only can help clarify the interaction mechanisms of IAA and SA in plants, it also helps to evaluate the health status of plants, which will promote the development of basic research in botany and precision agriculture. Full article
(This article belongs to the Special Issue Nano-Biosensors for Detection and Monitoring (2nd Edition))
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