Advanced Research in Antimicrobial and Antiviral Drugs
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 13840
Special Issue Editors
Interests: organic synthesis; drug discovery; drug design; synthesis
Interests: novel antibiotics; microbial quorum sensing; plant-protection; antimicrobial resistance; subinhibitory effects
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intensive use of antibiotics over the last decades has caused a significant increase in the antimicrobial resistance of many pathogens, such as viruses, bacteria and fungi. This was especially noticeable in the treatment of complications after suffering a relatively new and dangerous disease, namely COVID-19. For example, currently, there is a rapid increase in diseases with deep mycoses, which are extremely severe and cause high mortality rates. Among the pathogens with high resistance, bacteria and fungi require special attention, the latter of which are becoming increasingly drug resistant. Furthermore, some fungi, formerly known as typical saprotrophs (microorganisms that feed on dead remains), are pathogenic for humans. The number of fungi with resistance to all antifungal drugs is also growing, especially against the backdrop of the COVID-19 pandemic. As mentioned above, the main problem of resistance, despite the negative role of the pandemic, has its origin in the long-time high-level of antibiotics use worldwide, which is increasing every year. For instance, the use of antibiotics increased by 65% from 2000 to 2015, which is largely due to increased access to drugs in developing countries.
Antibiotic drugs are indispensable in the treatment of infectious diseases, as well as in the prevention of weakened immunity. However, due to the irrational and intensive use of such drugs, global problems regarding drug-resistant pathogens that have adapted to survive in the presence of antibiotics are increasing. On a daily basis, doctors find infections that do not respond to available antimicrobial treatment. The development of improved disease treatment against resistant strains is much more difficult and expensive, especially in relation to pan-resistant microbes (resistant to all drugs found), and desired healing effects may be not achieved.
As the available antimicrobials are losing their effectiveness and the development of new drugs has slowed, many infections are again threatening the lives of people globally, while medical procedures are becoming more risky. In this regard, the World Health Organization (WHO) has identified the problem of antimicrobial resistance as one of ten possible serious threats to public health. That is why the search for new antimicrobial drugs is very relevant, especially those based on new heterocyclic systems that have not been explicitly described before and have not been studied biologically.
Prof. Dr. Ivan V. Kulakov
Dr. Alexey Vasilchenko
Guest Editors
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Keywords
- antibacterial activity
- antituberculosis activity
- antiviral activity
- biologically active compounds
- nitrogen- and sulfur-containing heterocyclic compounds
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