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Diagnostics
Special Issues
Imaging-Based Diagnostics in Interventional Medicine
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Imaging-Based Diagnostics in Interventional Medicine

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (17 December 2018) | Viewed by 28077

Special Issue Editor

Prof. Dr. Rahmi Oklu

E-Mail Website
Guest Editor
Division of Interventional Radiology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA
Interests: interventional radiology; venous thrombosis; oncologic interventions, image guided intervention; bioengineering; medical devices; minimally invasive therapeutics; embolization; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The past 20 years have seen great advances in the field of interventional medicine, guided in large part by advances in diagnostic imaging (Ultrasound (US), Computed Tomography (CT), fluoroscopy, and Magnetic Resonance Imaging (MRI)). In addition to improving the planning and guiding of minimally-invasive interventional procedures, advances in diagnostic imaging have allowed for improved image quality while controlling patient radiation dose exposure, unenhanced angiography in peripheral interventions, more discriminatory tumor detection and assessments of treatment response in oncology and vascular disease patients, among other things. The objectives of this Special Issue are to comprehensively cover all aspects of imaging-based diagnostics in interventional medicine, with an emphasis on the latest findings and techniques within various imaging modalities. Original research and reviews are welcome.

Potential topics of the Special Issue include:

  • Radiogenomics
  • Non-contrast magnetic resonance angiography
  • Interventional oncology
  • Peripheral vascular disease
  • Magnetic resonance elastography
  • Percutaneous interventions
  • Artificial intelligence

Prof. Dr. Rahmi Oklu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Interventional Radiology
  • Interventional Oncology
  • Embolization
  • Vascular Diagnostics
  • Dynamic imaging
  • Radiogenomics

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Review

19 pages, 3108 KiB  
Review
Non-Invasive Assessment of Intravascular Pressure Gradients: A Review of Current and Proposed Novel Methods
by Tin-Quoc Nguyen, Kristoffer Lindskov Hansen, Thor Bechsgaard, Lars Lönn, Jørgen Arendt Jensen and Michael Bachmann Nielsen
Diagnostics 2019, 9(1), 5; https://doi.org/10.3390/diagnostics9010005 - 29 Dec 2018
Cited by 9 | Viewed by 5863
Abstract
Invasive catheterization is associated with a low risk of serious complications. However, although it is the gold standard for measuring pressure gradients, it induces changes to blood flow and requires significant resources. Therefore, non-invasive alternatives are urgently needed. Pressure gradients are routinely estimated [...] Read more.
Invasive catheterization is associated with a low risk of serious complications. However, although it is the gold standard for measuring pressure gradients, it induces changes to blood flow and requires significant resources. Therefore, non-invasive alternatives are urgently needed. Pressure gradients are routinely estimated non-invasively in clinical settings using ultrasound and calculated with the simplified Bernoulli equation, a method with several limitations. A PubMed literature search on validation of non-invasive techniques was conducted, and studies were included if non-invasively estimated pressure gradients were compared with invasively measured pressure gradients in vivo. Pressure gradients were mainly estimated from velocities obtained with Doppler ultrasound or magnetic resonance imaging. Most studies used the simplified Bernoulli equation, but more recent studies have employed the expanded Bernoulli and Navier–Stokes equations. Overall, the studies reported good correlation between non-invasive estimation of pressure gradients and catheterization. Despite having strong correlations, several studies reported the non-invasive techniques to either overestimate or underestimate the invasive measurements, thus questioning the accuracy of the non-invasive methods. In conclusion, more advanced imaging techniques may be needed to overcome the shortcomings of current methods. Full article
(This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine)
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9 pages, 636 KiB  
Review
Radiogenomics and Radiomics in Liver Cancers
by Aman Saini, Ilana Breen, Yash Pershad, Sailendra Naidu, M. Grace Knuttinen, Sadeer Alzubaidi, Rahul Sheth, Hassan Albadawi, Malia Kuo and Rahmi Oklu
Diagnostics 2019, 9(1), 4; https://doi.org/10.3390/diagnostics9010004 - 27 Dec 2018
Cited by 58 | Viewed by 8201
Abstract
Radiogenomics is a computational discipline that identifies correlations between cross-sectional imaging features and tissue-based molecular data. These imaging phenotypic correlations can then potentially be used to longitudinally and non-invasively predict a tumor’s molecular profile. A different, but related field termed radiomics examines the [...] Read more.
Radiogenomics is a computational discipline that identifies correlations between cross-sectional imaging features and tissue-based molecular data. These imaging phenotypic correlations can then potentially be used to longitudinally and non-invasively predict a tumor’s molecular profile. A different, but related field termed radiomics examines the extraction of quantitative data from imaging data and the subsequent combination of these data with clinical information in an attempt to provide prognostic information and guide clinical decision making. Together, these fields represent the evolution of biomedical imaging from a descriptive, qualitative specialty to a predictive, quantitative discipline. It is anticipated that radiomics and radiogenomics will not only identify pathologic processes, but also unveil their underlying pathophysiological mechanisms through clinical imaging alone. Here, we review recent studies on radiogenomics and radiomics in liver cancers, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastases to the liver. Full article
(This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine)
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Figure 1

12 pages, 678 KiB  
Review
Quiescent-Interval Single-Shot Magnetic Resonance Angiography
by Aman Saini, Alex Wallace, Hassan Albadawi, Sailendra Naidu, Sadeer Alzubaidi, M. Grace Knuttinen, Anshuman Panda and Rahmi Oklu
Diagnostics 2018, 8(4), 84; https://doi.org/10.3390/diagnostics8040084 - 18 Dec 2018
Cited by 9 | Viewed by 5544
Abstract
Lower extremity peripheral arterial disease (PAD) is a chronic, debilitating disease with a significant global burden. A number of diagnostic imaging techniques exist, including computed tomography angiography (CTA) and contrast-enhanced magnetic resonance angiography (CEMRA), to aid in PAD diagnosis and subsequent treatment planning. [...] Read more.
Lower extremity peripheral arterial disease (PAD) is a chronic, debilitating disease with a significant global burden. A number of diagnostic imaging techniques exist, including computed tomography angiography (CTA) and contrast-enhanced magnetic resonance angiography (CEMRA), to aid in PAD diagnosis and subsequent treatment planning. Due to concerns of renal toxicity or nephrogenic systemic fibrosis (NSF) for iodinated and gadolinium-based contrasts, respectively, a number of non-enhanced MRA (NEMRA) protocols are being increasingly used in PAD diagnosis. These techniques, including time of flight and phase contrast MRA, have previously demonstrated poor image quality, long acquisition times, and/or susceptibility to artifacts when compared to existing contrast-enhanced techniques. In recent years, Quiescent-Interval Single-Shot (QISS) MRA has been developed to overcome these limitations in NEMRA methods, with promising results. Here, we review the various screening and diagnostic tests currently used for PAD. The various NEMRA protocols are discussed, followed by a comprehensive review of the literature on QISS MRA to date. A particular emphasis is placed on QISS MRA feasibility studies and studies comparing the diagnostic accuracy and image quality of QISS MRA versus other diagnostic imaging techniques in PAD. Full article
(This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine)
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12 pages, 1245 KiB  
Review
Liquid Biopsy in Gastrointestinal Cancers
by Aman Saini, Yash Pershad, Hassan Albadawi, Malia Kuo, Sadeer Alzubaidi, Sailendra Naidu, M-Grace Knuttinen and Rahmi Oklu
Diagnostics 2018, 8(4), 75; https://doi.org/10.3390/diagnostics8040075 - 29 Oct 2018
Cited by 12 | Viewed by 7854
Abstract
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and [...] Read more.
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics. Full article
(This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine)
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